FGD4

Gene Name		FYVE, RhoGEF and PH domain containing 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Ruffle Cytoplasm Golgi Apparatus Cytosol Actin Cytoskeleton Lamellipodium Filopodium
	Molecular Function	Actin Binding Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Small GTPase Binding Metal Ion Binding
	Biological Process	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Regulation Of Cell Shape Lamellipodium Assembly Microspike Assembly Actin Cytoskeleton Organization Positive Regulation Of Rho GTPase Activity Positive Regulation Of Apoptotic Process Regulation Of Cdc42 GTPase Activity Positive Regulation Of GTPase Activity Filopodium Assembly Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		1 interactors: ACTA1
Entrez ID		121512
HPRD ID		16891
Ensembl ID		ENSG00000139132
Uniprot IDs		B7Z493 E9PJX4 F8W1R0 G3XA97 Q96M96
PDB IDs
Enriched GO Terms of Interacting Partners?		Skeletal Muscle Fiber Adaptation Skeletal Muscle Thin Filament Assembly Skeletal Myofibril Assembly Skeletal Muscle Adaptation Skeletal Muscle Fiber Development Myotube Cell Development Response To Lithium Ion Muscle Filament Sliding Actin-myosin Filament Sliding Actin-mediated Cell Contraction Muscle Fiber Development Myotube Differentiation Actin Filament-based Movement Myofibril Assembly Actomyosin Structure Organization Skeletal Muscle Tissue Development Skeletal Muscle Organ Development Cell Growth Striated Muscle Cell Development Muscle Cell Development Response To Mechanical Stimulus Muscle Contraction Striated Muscle Cell Differentiation Muscle System Process Muscle Organ Development Actin Filament Organization Striated Muscle Tissue Development Muscle Cell Differentiation Response To Metal Ion Muscle Tissue Development Response To Extracellular Stimulus Response To Inorganic Substance Response To Steroid Hormone Organelle Assembly Growth Muscle Structure Development Actin Cytoskeleton Organization Actin Filament-based Process
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