MVP and RNF111

Data Source:
BioGRID (two hybrid)

		MVP	RNF111
Description		major vault protein	ring finger protein 111
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GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Nucleoplasm Cytoplasm Cytosol PML Body Protein-containing Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding	Protein Binding SUMO Polymer Binding SMAD Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neutrophil Degranulation MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Pattern Specification Process Protein Ubiquitination Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Global Genome Nucleotide-excision Repair
Pathways		Neutrophil degranulation	Downregulation of SMAD2/3:SMAD4 transcriptional activity SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Formation of Incision Complex in GG-NER Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Apolipoprotein A1 levels ( 32203549) Asperger disorder ( 21182207) Atopic dermatitis ( 25865352) Cerebrospinal fluid AB1-42 levels ( 28247064) Metabolite levels ( 22916037) Social communication problems ( 24047820)
Interacting Genes		64 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DTX2 EPHX2 ESR1 FNDC3B GIT2 GOLGA2 HP IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2	54 interacting genes: ACTN3 ANAPC11 AP2M1 AXIN1 CREB1 CREBBP CSNK2A1 CTBP1 DTX3L EDARADD KRTAP1-1 KRTAP5-9 LCE4A LRSAM1 MARCHF7 MDFI MVP NBPF19 NOTCH2NLA PAX6 PHF7 PML PSME3 PTPN3 SDCBP2 SMAD3 SMAD6 SMAD7 SMURF2 SUMO1 SUMO2 SUMO3 TRAF5 TRIM21 TRIM8 TSG101 TSPYL1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2I UBE2K UBE2M UBE2N UBE2Q2 UBE2V1 UBE2W VAPB
Entrez ID		9961	54778
HPRD ID		05475	09318
Ensembl ID		ENSG00000013364	ENSG00000157450
Uniprot IDs		Q14764 X5D2M8 X5D7K9 X5DNU0	A0A024R5T5 Q6ZNA4
PDB IDs		1Y7X	2KIZ 5LG0 5LG7
Enriched GO Terms of Interacting Partners?
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