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TEAD2 and EPHA2
Data Source:
BioGRID
(fluorescent resonance energy transfer)
TEAD2
EPHA2
Description
TEA domain transcription factor 2
EPH receptor A2
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytosol
Intracellular Membrane-bounded Organelle
TEAD-YAP Complex
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Lamellipodium
Leading Edge Membrane
Lamellipodium Membrane
Ruffle Membrane
Neuron Projection
Receptor Complex
Tight Junction
Molecular Function
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coactivator Binding
DNA-binding Transcription Factor Activity
Protein Binding
Disordered Domain Specific Binding
Sequence-specific Double-stranded DNA Binding
Virus Receptor Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Transmembrane-ephrin Receptor Activity
Protein Binding
ATP Binding
Cadherin Binding
Biological Process
Vasculogenesis
Neural Tube Closure
Embryonic Heart Tube Morphogenesis
Regulation Of Transcription, DNA-templated
Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Notochord Development
Hippo Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Development
Lateral Mesoderm Development
Embryonic Organ Development
Negative Regulation Of Cell Death
Protein-containing Complex Assembly
Cellular Response To Retinoic Acid
Regulation Of Stem Cell Differentiation
Skeletal System Development
Vasculogenesis
Osteoblast Differentiation
Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis
Inflammatory Response
Cell Adhesion
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Axon Guidance
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Lamellipodium Assembly
Notochord Formation
Cell Migration
Negative Regulation Of Angiogenesis
Peptidyl-tyrosine Phosphorylation
Neural Tube Development
Keratinocyte Differentiation
Osteoclast Differentiation
Negative Regulation Of Chemokine Production
Mammary Gland Epithelial Cell Proliferation
Regulation Of Cell Adhesion Mediated By Integrin
Positive Regulation Of Kinase Activity
Post-anal Tail Morphogenesis
Protein Kinase B Signaling
Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Angiogenesis
CAMP Metabolic Process
Viral Entry Into Host Cell
Bone Remodeling
Ephrin Receptor Signaling Pathway
Axial Mesoderm Formation
Cell Motility
Defense Response To Gram-positive Bacterium
Negative Regulation Of Protein Kinase B Signaling
Notochord Cell Development
Cell Chemotaxis
Branching Involved In Mammary Gland Duct Morphogenesis
Lens Fiber Cell Morphogenesis
Regulation Of ERK1 And ERK2 Cascade
Response To Growth Factor
Protein Localization To Plasma Membrane
Activation Of GTPase Activity
Negative Regulation Of Lymphangiogenesis
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Bicellular Tight Junction Assembly
Pericyte Cell Differentiation
Pathways
YAP1- and WWTR1 (TAZ)-stimulated gene expression
RUNX3 regulates YAP1-mediated transcription
EPH-Ephrin signaling
EPH-Ephrin signaling
EPHA-mediated growth cone collapse
EPHA-mediated growth cone collapse
EPH-ephrin mediated repulsion of cells
EPH-ephrin mediated repulsion of cells
Drugs
Dasatinib
Phosphoaminophosphonic Acid-Adenylate Ester
Regorafenib
Fostamatinib
Diseases
GWAS
Blood protein levels (
30072576
)
Gamma glutamyl transferase levels (
29403010
)
Liver enzyme levels (gamma-glutamyl transferase) (
22001757
)
Interacting Genes
45 interacting genes:
AKT1
ARNT
AURKA
BCL2L15
BECN1
C14orf39
CCND2
CDK4
CDK6
CDKN2A
CDKN2B
DACH1
EPHA2
FGFR4
FZR1
GLIS1
GLIS2
GNG13
HGF
HIF1A
INPP5A
LATS2
MAP2K3
MAP2K5
MAP3K5
MYC
NCOA1
NEDD4
NFIC
NSD3
RAF1
RASSF1
RUNX1
SAA2
SOX3
STK11
TERT
TP53
TRIM3
USF2
VGLL1
VGLL3
VGLL4
WWTR1
YAP1
84 interacting genes:
ABCB5
ACP1
AKT1
APP
ARAF
ARNT
AURKA
BECN1
CBL
CBLC
CCND2
CD44
CDC42
CDH5
CDK17
CDK4
CDK6
CDKN2A
CDKN2B
CDKN2C
CLDN4
DUSP14
DUSP18
DUSP19
DUSP26
DUSP29
EFNA1
EFNA2
EFNA3
EFNA4
EFNA5
EGFR
ERBB2
FGFR4
FZR1
GATAD1
GLIS2
GRB2
GRK2
GRM1
HGF
HIF1A
ILKAP
KDELR2
KPNA3
LATS2
LSM7
MAP2K5
MAP2K6
MAPK14
MDM4
MET
MSH2
MYC
NF1
NF2
NFIC
NUDT9
PDGFRA
PIK3R1
PIK3R2
PPM1L
PSME2
PTEN
PTK2
PTPN11
PTPN7
PTPRR
RAF1
RASA1
RASSF1
RBL1
RELA
SHC1
SLA
STK11
STYX
TEAD2
TIAM1
TNFAIP1
TP53
TPTE
TPTE2
UBE4A
Entrez ID
8463
1969
HPRD ID
03432
01494
Ensembl ID
ENSG00000074219
ENSG00000142627
Uniprot IDs
A0A024QZE2
Q15562
A0A024QZA8
P29317
PDB IDs
3L15
5DQ8
5DQE
5EMV
5HGU
6CDY
6E5G
6S60
6S64
6S66
6S69
6S6J
6UYB
6UYC
6VAH
1MQB
2E8N
2K9Y
2KSO
2X10
2X11
3C8X
3CZU
3FL7
3HEI
3HPN
3KKA
3MBW
3MX0
3SKJ
4P2K
4PDO
4TRL
5EK7
5I9U
5I9V
5I9W
5I9X
5I9Y
5I9Z
5IA0
5IA1
5IA2
5IA3
5IA4
5IA5
5NJZ
5NK0
5NK1
5NK2
5NK3
5NK4
5NK5
5NK6
5NK7
5NK8
5NK9
5NKA
5NKB
5NKC
5NKD
5NKE
5NKF
5NKG
5NKH
5NKI
5NZ9
6B9L
6F7M
6F7N
6FNF
6FNG
6FNH
6HES
6HET
6HEU
6HEV
6HEW
6HEX
6HEY
6NJZ
6NK0
6NK1
6NK2
6NKP
6Q7B
6Q7C
6Q7D
6Q7E
6Q7F
6Q7G
6RW2
7CZE
7CZF
Enriched GO Terms of Interacting Partners
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