DYNC2H1 and CARD18

Data Source:
BioGRID (affinity chromatography technology)

		DYNC2H1	CARD18
Description		dynein cytoplasmic 2 heavy chain 1	caspase recruitment domain family member 18
Image
GO Annotations	Cellular Component	Golgi Apparatus Cytoplasmic Dynein Complex Microtubule Plasma Membrane Cilium Axoneme Dynein Complex Motile Cilium Apical Part Of Cell Extracellular Exosome Ciliary Tip	Protein-containing Complex
	Molecular Function	Motor Activity Protein Binding ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding CARD Domain Binding Caspase Binding
	Biological Process	Kidney Development Microtubule-based Movement Golgi Organization Determination Of Left/right Symmetry Dorsal/ventral Pattern Formation Protein Processing Spinal Cord Motor Neuron Differentiation Embryonic Limb Morphogenesis Forebrain Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly Coronary Vasculature Development Protein Localization To Cilium Non-motile Cilium Assembly	Inflammatory Response Negative Regulation Of Protein Binding Negative Regulation Of Interleukin-1 Beta Production Regulation Of Apoptotic Process Inhibition Of Cysteine-type Endopeptidase Activity
Pathways		Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases		Short rib-polydactyly syndrome Asphyxiating thoracic dystrophy; Jeune syndrome
GWAS		Adult body size ( 32376654) Coronary artery disease ( 32469254 30104761 33020668) Diisocyanate-induced asthma ( 25918132) Response to lurasidone in schizophrenia ( 29730043) Small-cell lung cancer (survival) ( 21118971) Spine bone mineral density and alcohol drinking ( 28012008) Toenail selenium levels ( 25343990) Tuberculosis ( 24057671)
Interacting Genes		3 interacting genes: DYNC2LI1 MTNR1B PAXIP1	2 interacting genes: CARD17 CARD8
Entrez ID		79659	59082
HPRD ID		10344	16099
Ensembl ID		ENSG00000187240	ENSG00000255501
Uniprot IDs		Q8NCM8	P57730
PDB IDs		4RH7	1DGN
Enriched GO Terms of Interacting Partners?
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