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ZXDC and NR1H2
Data Source:
HPRD
(two hybrid)
ZXDC
NR1H2
Description
ZXD family zinc finger C
nuclear receptor subfamily 1 group H member 2
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Nucleus
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Molecular Function
Transcription Coregulator Activity
Transcription Coactivator Activity
Protein Binding
LRR Domain Binding
Metal Ion Binding
C2H2 Zinc Finger Domain Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Nuclear Receptor Activity
Protein Binding
Zinc Ion Binding
Apolipoprotein A-I Receptor Binding
Retinoid X Receptor Binding
ATPase Binding
Biological Process
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Transcription, DNA-templated
Negative Regulation Of Transcription By RNA Polymerase II
Transcription Initiation From RNA Polymerase II Promoter
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Positive Regulation Of Triglyceride Biosynthetic Process
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Lipid Storage
Negative Regulation Of Cholesterol Storage
Cell Differentiation
Response To Nutrient Levels
Positive Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Lipid Transport
Positive Regulation Of Cholesterol Transport
Phosphatidylcholine Acyl-chain Remodeling
Cholesterol Homeostasis
Positive Regulation Of Fatty Acid Biosynthetic Process
Negative Regulation Of Proteolysis
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Retinoic Acid Receptor Signaling Pathway
Negative Regulation Of Pinocytosis
Positive Regulation Of Lipoprotein Lipase Activity
Negative Regulation Of Interferon-gamma-mediated Signaling Pathway
Positive Regulation Of High-density Lipoprotein Particle Assembly
Positive Regulation Of Pancreatic Juice Secretion
Positive Regulation Of Secretion Of Lysosomal Enzymes
Negative Regulation Of Cold-induced Thermogenesis
Negative Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
PPARA activates gene expression
Nuclear Receptor transcription pathway
SUMOylation of intracellular receptors
VLDLR internalisation and degradation
NR1H2 & NR1H3 regulate gene expression linked to lipogenesis
NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake
NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose
NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis
Drugs
GW-3965
Benzenesulfinic acid
TO-901317
1,1,1,3,3,3-HEXAFLUORO-2-{4-[(2,2,2-TRIFLUOROETHYL)AMINO]PHENYL}PROPAN-2-OL
Diacerein
Rhein
Diseases
GWAS
Metabolite levels (
23823483
)
Pursuit maintenance gain (
29064472
)
Interacting Genes
17 interacting genes:
APP
ATXN1
CBR4
CIITA
JTB
MEPE
MTDH
NR1H2
NR1H3
POGZ
RORA
SH3GL2
SMN1
SUOX
TK1
WDR5
ZMYND19
51 interacting genes:
BAG6
CDKN1A
CHD3
COL4A5
CSAD
DNMT3L
DUSP12
ERG28
FAF1
FOXO3
HDAC4
HMGXB4
ING3
KDM1A
LAMC3
MDFI
MED1
MPP1
NCOA1
NCOA3
NCOA6
NCOR1
NCOR2
NPY
NR0B2
NRIP1
PCDH17
PPARA
PPARD
PPARG
PRKCA
RARA
RHOU
RMI1
ROBO2
RXRA
RXRB
RXRG
SCG5
SIRT1
SMPD1
SORBS2
SPRY2
SUV39H1
TMEM161A
UBE2D1
UBE2I
VDR
VIM
YY1
ZXDC
Entrez ID
79364
7376
HPRD ID
14420
02660
Ensembl ID
ENSG00000070476
ENSG00000131408
Uniprot IDs
Q2QGD7
F1D8P7
P55055
PDB IDs
1P8D
1PQ6
1PQ9
1PQC
1UPV
1UPW
3KFC
3L0E
4DK7
4DK8
4NQA
4RAK
5HJP
5I4V
5JY3
5KYA
5KYJ
6JIO
6K9G
6K9H
6K9M
6S4N
6S4T
6S4U
6S5K
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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