THRB and MED21

Data Source:
HPRD (in vitro)

		THRB	MED21
Description		thyroid hormone receptor beta	mediator complex subunit 21
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Nuclear Body	Mediator Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Enzyme Binding Chromatin DNA Binding Thyroid Hormone Binding Sequence-specific Double-stranded DNA Binding	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Thyroid Hormone Mediated Signaling Pathway Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Sensory Perception Of Sound Negative Regulation Of Female Receptivity Regulation Of Heart Contraction Female Courtship Behavior Hormone-mediated Signaling Pathway Cell Differentiation Negative Regulation Of Eye Photoreceptor Cell Development Positive Regulation Of Transcription By RNA Polymerase II Retinal Cone Cell Development Type I Pneumocyte Differentiation Cellular Response To Thyroid Hormone Stimulus Retinal Cone Cell Apoptotic Process	Regulation Of Transcription By RNA Polymerase II RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs		Liothyronine Levothyroxine Dextrothyroxine Amiodarone Liotrix [3,5-Dibromo-4-(4-Hydroxy-3-Phenethylcarbamoyl-Phenoxy)-Phenyl]-Acetic Acid KB-141 2-[4-(4-Hydroxy-3-Isopropyl-Phenoxy)-3,5-Dimethyl-Phenyl]-2h-[1,2,4]Triazine-3,5-Dione Tiratricol GC-24 Eprotirome MB07811 Sobetirome 1-(4-HEXYLPHENYL)PROP-2-EN-1-ONE Thyroid, porcine
Diseases
GWAS		Acne (severe) ( 24927181) Amyotrophic lateral sclerosis (sporadic) ( 24529757) antipsychotic drug dosage in schizophrenia or schizoaffective disorder ( 26821981) Asthma ( 29273806) Atrial fibrillation ( 30061737 29892015) Carotid intima media thickness x smoking interaction ( 32117412) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Erythrocyte cadmium concentration ( 27005419) Extremely high intelligence ( 29520040) Familial squamous cell lung carcinoma ( 29924316) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 29403010 32888494 20139978 27863252 28017375) Mean corpuscular hemoglobin concentration ( 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 20139978 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Menarche (age at onset) ( 25231870) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Myopia ( 27182965) Platelet distribution width ( 32888494) PR interval ( 32439900) Red blood cell count ( 29403010 32888494 27863252) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Relative wall thickness x antihypertensive treatment interaction ( 31407531) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure in sickle cell anemia ( 24058526) Triglyceride levels ( 32203549 32154731)	Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		58 interacting genes: ACVR1 ADAT3 ANP32A ATF2 BRD8 BTG1 C1D CAMK2B CCND1 CNOT1 COPS2 CTCF ESR1 FOXO1 HDAC2 HDAC3 HMGN3 JMJD1C LRIF1 MECR MED1 MED21 MMS19 MPG NCOA1 NCOA2 NCOA3 NCOA6 NCOR1 NCOR2 NR2F6 NRBF2 NRIP1 NSD1 PPARGC1A PPARGC1B PRKDC PRMT1 PRMT2 PSMC3IP PSMC5 RANBP9 RARA ROBO4 RXRA RXRB RXRG SRC TBL1X TP53 TRIP10 TRIP12 TRIP13 TRIP4 TRIP6 TSG101 UBE2I ZNHIT3	30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MED29 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1
Entrez ID		7068	9412
HPRD ID		07521	09156
Ensembl ID		ENSG00000151090	ENSG00000152944
Uniprot IDs		A0A024R2I8 P10828	A0A024RAW0 Q13503
PDB IDs		1BSX 1N46 1NAX 1NQ0 1NQ1 1NQ2 1NUO 1Q4X 1R6G 1XZX 1Y0X 2J4A 2NLL 2PIN 3D57 3GWS 3IMY 3JZC 4ZO1 6KKB 6KKE 6KNU 6KNV 6KNW
Enriched GO Terms of Interacting Partners?
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