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RPLP1 and PPP2CB
Data Source:
BioGRID
(two hybrid)
RPLP1
PPP2CB
Description
ribosomal protein lateral stalk subunit P1
protein phosphatase 2 catalytic subunit beta
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Focal Adhesion
Cytosolic Large Ribosomal Subunit
Protein Phosphatase Type 2A Complex
Chromosome, Centromeric Region
Spindle Pole
Nucleus
Cytosol
Molecular Function
Structural Constituent Of Ribosome
Protein Binding
Protein Kinase Activator Activity
Ribonucleoprotein Complex Binding
Protein Serine/threonine Phosphatase Activity
Protein Binding
Protein C-terminus Binding
Metal Ion Binding
Tau Protein Binding
Protein Serine Phosphatase Activity
Protein Threonine Phosphatase Activity
Biological Process
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Cytoplasmic Translation
Translation
Translational Initiation
Translational Elongation
SRP-dependent Cotranslational Protein Targeting To Membrane
Viral Transcription
Activation Of Protein Kinase Activity
Protein Dephosphorylation
Apoptotic Mitochondrial Changes
Response To Lead Ion
Regulation Of Gene Expression
Response To Endoplasmic Reticulum Stress
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Ras Protein Signal Transduction
Response To Antibiotic
Peptidyl-serine Dephosphorylation
Positive Regulation Of Microtubule Binding
Pathways
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Response of EIF2AK4 (GCN2) to amino acid deficiency
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Inhibition of replication initiation of damaged DNA by RB1/E2F1
Spry regulation of FGF signaling
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Integration of energy metabolism
PP2A-mediated dephosphorylation of key metabolic factors
DARPP-32 events
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
ERK/MAPK targets
ERKs are inactivated
MASTL Facilitates Mitotic Progression
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
CTLA4 inhibitory signaling
Platelet sensitization by LDL
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
RHO GTPases Activate Formins
RAF activation
Negative regulation of MAPK pathway
Regulation of TP53 Degradation
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Mitotic Prometaphase
Cyclin D associated events in G1
Cyclin A/B1/B2 associated events during G2/M transition
Regulation of glycolysis by fructose 2,6-bisphosphate metabolism
EML4 and NUDC in mitotic spindle formation
Drugs
Vitamin E
Diseases
GWAS
Chronic lymphocytic leukemia (
28165464
24292274
23770605
)
Male-pattern baldness (
27182965
)
Non-response to citalopram or escitalopram and depression (
27622933
)
Daytime sleep phenotypes (
27126917
)
Interacting Genes
35 interacting genes:
ANKRD13B
ASCC2
ATP5MF
BRD7
C11orf58
C15orf39
CDIPT
CDK2AP2
CLIC1
CSNK2A1
EEF1A1
GEMIN7
GSK3B
LRIF1
MAP1LC3B
MPC2
NSF
NUDT21
NUDT3
PDCD4
PFDN1
PPP2CB
PTN
RCHY1
RPA2
RPLP2
RPS6KA6
SAT1
SGO1
SUOX
TAB1
TPT1
TUBB2A
UBE2D3
XRCC6
41 interacting genes:
ACP5
AURKA
AXIN1
BHLHE41
BUB1
C22orf39
DOCK7
DYNLT2B
EGFR
GAD1
GSTA1
HK3
KRAS
LCMT1
MAK
MAPT
MID1
MLH1
MLH3
NRAS
PACS1
PDGFRL
PLXNA3
PMS2
PRKCB
PTPRJ
RAF1
RELA
RPLP1
SGO1
SMAD4
SRC
STK11
TAB1
TAB2
TGFBR2
TIPRL
TLX1
TRMT61B
ZFP28
ZNF775
Entrez ID
6176
5516
HPRD ID
01611
01487
Ensembl ID
ENSG00000137818
ENSG00000104695
Uniprot IDs
A0A024R608
P05386
A0A140VJS0
P62714
PDB IDs
2LBF
4BEH
4V6X
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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