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RAP1GDS1 and LEF1
Data Source:
HPRD
(in vitro, in vivo, two hybrid)
RAP1GDS1
LEF1
Description
Rap1 GTPase-GDP dissociation stimulator 1
lymphoid enhancer binding factor 1
Image
No pdb structure
GO Annotations
Cellular Component
Mitochondrion
Endoplasmic Reticulum
Cytosol
Extracellular Exosome
Nucleus
Nucleoplasm
Transcription Regulator Complex
Cytoplasm
Protein-DNA Complex
Beta-catenin-TCF Complex
Molecular Function
GTPase Activator Activity
Protein Binding
RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
Chromatin Binding
DNA-binding Transcription Factor Activity
Protein Binding
Beta-catenin Binding
DNA Binding, Bending
Estrogen Receptor Activity
Estrogen Receptor Binding
Histone Binding
Histone Deacetylase Binding
Sequence-specific DNA Binding
Gamma-catenin Binding
Armadillo Repeat Domain Binding
C2H2 Zinc Finger Domain Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Vascular Associated Smooth Muscle Contraction
Myosin Filament Assembly
Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration
Positive Regulation Of GTPase Activity
Positive Regulation Of Mitochondrial Calcium Ion Concentration
Negative Regulation Of Transcription By RNA Polymerase II
Branching Involved In Blood Vessel Morphogenesis
Osteoblast Differentiation
Somitogenesis
Epithelial To Mesenchymal Transition
Sprouting Angiogenesis
Regulation Of Transcription By RNA Polymerase II
Wnt Signaling Pathway, Calcium Modulating Pathway
Positive Regulation Of Cell Population Proliferation
Positive Regulation Of Gene Expression
Positive Regulation Of Epithelial To Mesenchymal Transition
Dentate Gyrus Development
Forebrain Radial Glial Cell Differentiation
Forebrain Neuroblast Division
Formation Of Radial Glial Scaffolds
Regulation Of Wnt Signaling Pathway
Neutrophil Differentiation
Embryonic Limb Morphogenesis
Positive Regulation Of Cell Migration
BMP Signaling Pathway
Positive Regulation Of Granulocyte Differentiation
Mammary Gland Development
Negative Regulation Of Interleukin-13 Production
Negative Regulation Of Interleukin-4 Production
Negative Regulation Of Interleukin-5 Production
T Cell Receptor V(D)J Recombination
B Cell Proliferation
Odontogenesis Of Dentin-containing Tooth
Negative Regulation Of Apoptotic Process
Negative Regulation Of DNA Binding
Steroid Hormone Mediated Signaling Pathway
Tongue Development
Positive Regulation By Host Of Viral Transcription
Histone H3 Acetylation
Histone H4 Acetylation
T-helper 1 Cell Differentiation
Positive Regulation Of Gamma-delta T Cell Differentiation
Negative Regulation Of Striated Muscle Tissue Development
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Paraxial Mesoderm Formation
Sensory Perception Of Taste
Anatomical Structure Regression
Canonical Wnt Signaling Pathway
Face Morphogenesis
Cell Chemotaxis
Chorio-allantoic Fusion
Trachea Gland Development
Secondary Palate Development
Cellular Response To Cytokine Stimulus
Cellular Response To Interleukin-4
Positive Regulation Of Cell Proliferation In Bone Marrow
Negative Regulation Of Apoptotic Process In Bone Marrow Cell
Negative Regulation Of Estrogen Receptor Binding
Apoptotic Process Involved In Blood Vessel Morphogenesis
Beta-catenin-TCF Complex Assembly
Pathways
Formation of the beta-catenin:TCF transactivating complex
Formation of the beta-catenin:TCF transactivating complex
Deactivation of the beta-catenin transactivating complex
Ca2+ pathway
Binding of TCF/LEF:CTNNB1 to target gene promoters
Repression of WNT target genes
Repression of WNT target genes
Transcriptional Regulation by VENTX
RUNX3 regulates WNT signaling
Transcriptional regulation of granulopoiesis
Transcriptional regulation of granulopoiesis
Drugs
Etacrynic acid
Diseases
GWAS
Biochemical measures (
19260141
)
Response to fenofibrate (total cholesterol levels) (
27002377
)
Airflow obstruction (
22837378
)
Blond vs. brown/black hair color (
30531825
)
Chronic lymphocytic leukemia (
28165464
26956414
23770605
)
Diastolic blood pressure (
27841878
)
Medication use (calcium channel blockers) (
31015401
)
Metabolic traits (
19060910
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
22291604
)
Systolic blood pressure (
27841878
30578418
)
Tooth agenesis (mandibular second premolars) (
29364747
)
Interacting Genes
23 interacting genes:
CDC42
DIRAS1
DIRAS2
DOC2A
EGFR
HRAS
KIFAP3
KRAS
MBIP
NRAS
PLEKHB1
PTPRF
PUF60
RAB6B
RAC1
RAP1A
RAP2B
RAP2C
RHOA
RNF19B
RRAS
RRAS2
ZNF451
33 interacting genes:
ALX4
ALYREF
AURKA
BAX
BUB1
CDX1
CTNNB1
DPYSL2
EP300
KPNA1
KPNA2
MITF
MLH1
MLH3
MSH2
NLK
NOTCH1
NRAS
PIAS4
PITX2
RB1
RUNX2
SMAD1
SMAD2
SMAD3
SMAD4
STK11
SUMO2
TLE1
TLE2
TRA
UBTF
ZBTB3
Entrez ID
5910
51176
HPRD ID
11763
01075
Ensembl ID
ENSG00000138698
ENSG00000138795
Uniprot IDs
B3KNU0
P52306
Q6U7G8
Q659G9
Q9UJU2
PDB IDs
5XGC
5ZHX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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