NR4A2 and CDKN1C

Data Source:
HPRD (in vitro)

		NR4A2	CDKN1C
Description		nuclear receptor subfamily 4 group A member 2	cyclin dependent kinase inhibitor 1C
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Speck Protein-containing Complex	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Nuclear Receptor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Glucocorticoid Receptor Binding Retinoid X Receptor Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Neuron Migration Response To Amphetamine Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Adult Locomotory Behavior Post-embryonic Development Central Nervous System Projection Neuron Axonogenesis Central Nervous System Neuron Differentiation Habenula Development Intracellular Receptor Signaling Pathway Cellular Response To Extracellular Stimulus Cellular Response To Oxidative Stress Regulation Of Dopamine Metabolic Process Dopamine Biosynthetic Process Neuron Maturation Positive Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Regulation Of Respiratory Gaseous Exchange Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II General Adaptation Syndrome Canonical Wnt Signaling Pathway Cellular Response To Corticotropin-releasing Hormone Stimulus Dopaminergic Neuron Differentiation Midbrain Dopaminergic Neuron Differentiation Negative Regulation Of Apoptotic Signaling Pathway	Cell Cycle Arrest Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity
Pathways		Nuclear Receptor transcription pathway SUMOylation of intracellular receptors	Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Parkinson's disease (PD)	Beckwith-Wiedemann syndrome Adrenal carcinoma
GWAS		Age at voice drop ( 27182965) anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Chronic obstructive pulmonary disease ( 30804561) Depression ( 29700475) HDL cholesterol levels ( 32109663) Leisure-time exercise behaviour ( 30102679) Leisure-time exercise behaviour (age-stratified) ( 30102679) Lung function (FEV1/FVC) ( 30061609) Menarche (age at onset) ( 21102462 25231870) Response to statin therapy ( 20339536)	Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061)
Interacting Genes		15 interacting genes: BAZ1B CDKN1C CDKN2D COPS5 MAPK1 ODAD2 PIAS4 PPARG RPS6KA1 RXRA RXRB SMARCA2 SMARCA4 TCEAL5 VHL	10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2
Entrez ID		4929	1028
HPRD ID		03493	02913
Ensembl ID		ENSG00000153234	ENSG00000129757
Uniprot IDs		F1D8N6 F1DAL2 P43354 Q53EL4	P49918
PDB IDs		1OVL 5Y41 5YD6 6DDA 6L6L 6L6Q
Enriched GO Terms of Interacting Partners?
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