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MIR34C and XRN1
Data Source:
BioGRID
(unspecified method)
MIR34C
XRN1
Description
microRNA 34c
5'-3' exoribonuclease 1
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
P-body
Nucleus
Cytosol
Plasma Membrane
Membrane
Dendrite
Neuronal Cell Body
Synapse
Molecular Function
G-quadruplex RNA Binding
RNA Binding
5'-3' Exoribonuclease Activity
Protein Binding
G-quadruplex DNA Binding
Telomerase RNA Binding
Biological Process
Gene Silencing By MiRNA
Negative Regulation Of Protein Kinase B Signaling
Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Negative Regulation Of Sprouting Angiogenesis
Positive Regulation Of Connective Tissue Replacement
Nuclear-transcribed MRNA Catabolic Process
RRNA Catabolic Process
Negative Regulation Of Translation
Negative Regulation Of Telomere Maintenance Via Telomerase
Response To Testosterone
Regulation Of MRNA Stability
Nuclear MRNA Surveillance
Histone MRNA Catabolic Process
Cellular Response To Cycloheximide
RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Cellular Response To Puromycin
Pathways
mRNA decay by 5' to 3' exoribonuclease
Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS
Allergic disease (asthma, hay fever or eczema) (
29785011
)
Asthma or allergic disease (pleiotropy) (
29785011
)
Bipolar disorder (
31043756
)
Benign childhood epilepsy with centro-temporal spikes (
32580138
)
Birth weight (
31043758
)
Heel bone mineral density (
30598549
)
Mean spheric corpuscular volume (
32888494
)
Mosquito bite size (
28199695
)
Waist-hip ratio (
28552196
)
Interacting Genes
78 interacting genes:
AIMP1
AIMP2
APOBEC3B
C1QBP
DARS1
DDX1
DDX21
DDX3X
DHX36
EDC4
EIF2AK2
EPRS1
FAM98A
FUS
HNRNPA0
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPF
HNRNPH1
HNRNPH2
HNRNPH3
HNRNPK
HNRNPL
HNRNPM
HNRNPR
IARS1
IGF2BP1
IGF2BP2
IGF2BP3
KARS1
KNOP1
LARP7
LARS1
LIN28A
LRPPRC
MARS1
MATR3
MSI1
MSI2
NOL6
NONO
NUDT21
PDCD11
PRMT1
PTBP1
PTBP3
PTCD3
PUF60
PURA
QARS1
QKI
RARS1
RBFOX2
RBM14
RBM4
RBMS2
RTCA
RTCB
SF3B1
SF3B2
SF3B3
SF3B4
SFPQ
STRBP
SYNCRIP
TAF15
TRA2A
TRA2B
U2SURP
UPF1
UTP20
XRN1
YBX1
YBX2
YBX3
ZNF346
ZNF385A
66 interacting genes:
ADGRE5
ALDOA
ANGPTL6
AP1G2
ATP5MC2
B3GALT6
BAG6
C1GALT1
CBX5
CCT5
CENPBD1
CHD4
CTSB
CTSH
DCP1B
DNASE2
DPP7
DXO
EXOSC1
EXOSC10
EXOSC6
EXOSC8
FADS1
FBXO7
GLMP
HEATR1
HERC2P4
HNRNPA1
KATNB1
LDHA
LEPR
LGALS3BP
LINC01541
LSM4
MAN2C1
MFSD5
MIR34C
MIR429
MIR7-1
MTCH2
MTREX
NDUFA13
NDUFB10
NDUFB9
PABPC4
PLEKHG2
POLD2
PPP2CA
PRADC1
PSMB5
RBMX
RNF187
SDHB
SKIV2L
SMARCD2
SNHG1
SPATA20
SRRM2
STAM2
TMEM50A
UPF1
UPF2
UPF3B
VWA5B2
WAPL
ZFP36
Entrez ID
407042
54464
HPRD ID
10470
Ensembl ID
ENSG00000207562
ENSG00000114127
Uniprot IDs
Q8IZH2
PDB IDs
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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