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KRTAP10-8 and PKD2
Data Source:
BioGRID
(two hybrid)
KRTAP10-8
PKD2
Description
keratin associated protein 10-8
polycystin 2, transient receptor potential cation channel
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Keratin Filament
Polycystin Complex
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Plasma Membrane
Integral Component Of Plasma Membrane
Cell-cell Junction
Cilium
Basal Plasma Membrane
Membrane
Lamellipodium
Cytoplasmic Vesicle Membrane
Motile Cilium
Filamentous Actin
Cation Channel Complex
Ciliary Basal Body
Basal Cortex
Ciliary Membrane
Extracellular Exosome
Integral Component Of Cytoplasmic Side Of Endoplasmic Reticulum Membrane
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Mitotic Spindle
Non-motile Cilium
Molecular Function
Protein Binding
Identical Protein Binding
Signaling Receptor Binding
Voltage-gated Ion Channel Activity
Voltage-gated Calcium Channel Activity
Voltage-gated Sodium Channel Activity
Voltage-gated Potassium Channel Activity
Cation Channel Activity
Calcium Channel Activity
Potassium Channel Activity
Calcium Ion Binding
Protein Binding
Cytoskeletal Protein Binding
Outward Rectifier Potassium Channel Activity
Voltage-gated Cation Channel Activity
Identical Protein Binding
Protein Homodimerization Activity
Actinin Binding
HLH Domain Binding
Ion Channel Binding
Calcium-induced Calcium Release Activity
ATPase Binding
Phosphoprotein Binding
Muscle Alpha-actinin Binding
Biological Process
Keratinization
Branching Involved In Ureteric Bud Morphogenesis
Liver Development
Embryonic Placenta Development
Heart Looping
Detection Of Nodal Flow
Calcium Ion Transport
Cell Cycle Arrest
Receptor Signaling Pathway Via JAK-STAT
Determination Of Left/right Symmetry
Heart Development
Negative Regulation Of Cell Population Proliferation
Wnt Signaling Pathway
Spinal Cord Development
Neural Tube Development
Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity
Cellular Response To Reactive Oxygen Species
Metanephric Part Of Ureteric Bud Development
Sodium Ion Transmembrane Transport
Aorta Development
Regulation Of Cell Population Proliferation
Cytoplasmic Sequestering Of Transcription Factor
Cilium Organization
Positive Regulation Of Nitric Oxide Biosynthetic Process
Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Positive Regulation Of Transcription By RNA Polymerase II
Detection Of Mechanical Stimulus
Release Of Sequestered Calcium Ion Into Cytosol
Protein Tetramerization
Protein Homotetramerization
Protein Heterotetramerization
Centrosome Duplication
Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity
Placenta Blood Vessel Development
Renal Tubule Morphogenesis
Renal Artery Morphogenesis
Calcium Ion Transmembrane Transport
Positive Regulation Of Cell Cycle Arrest
Cellular Response To Calcium Ion
Cellular Response To CAMP
Cellular Response To Hydrostatic Pressure
Cellular Response To Osmotic Stress
Cellular Response To Fluid Shear Stress
Potassium Ion Transmembrane Transport
Determination Of Liver Left/right Asymmetry
Metanephric Mesenchyme Development
Mesonephric Tubule Development
Mesonephric Duct Development
Metanephric Smooth Muscle Tissue Development
Metanephric Cortex Development
Metanephric Ascending Thin Limb Development
Metanephric Cortical Collecting Duct Development
Metanephric Distal Tubule Development
Metanephric S-shaped Body Morphogenesis
Regulation Of Calcium Ion Import
Inorganic Cation Transmembrane Transport
Cell-cell Signaling By Wnt
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
Keratinization
VxPx cargo-targeting to cilium
VxPx cargo-targeting to cilium
Drugs
Diseases
Polycystic kidney disease
GWAS
Coffee consumption (cups per day) (
25288136
)
Dental caries (
23064961
)
Gout (
30899057
)
Hyperuricemia (
28776340
)
Serum uric acid levels in response to allopurinol in gout (
25676789
)
Uric acid levels (
29558500
)
Interacting Genes
388 interacting genes:
-
ACY3
ADAM12
ADAMTS1
ADAMTSL3
ADAMTSL4
AEBP2
AEN
AK3
ALDH3B1
ALPI
ALPP
AMMECR1
ANKS1A
AP1M1
APOL6
AQP1
AREG
ARID5A
ASPSCR1
ATG9A
ATP5F1D
AVPI1
AXIN2
BAHD1
BCL6B
BEX2
BMP7
BRME1
C10orf62
C11orf87
C17orf50
C19orf25
C22orf39
C2orf68
C3
CAMK1G
CARD10
CARHSP1
CATSPER1
CCDC26
CCNJL
CHIC2
CHRD
CHRNG
CLK4
CNNM3
COL8A1
COX17
CRCT1
CREB5
CRH
CRY2
CSF1
CTRC
CYP2S1
CYSRT1
DAAM2
DCX
DDX43
DDX55
DDX6
DERL2
DHRS1
DHX57
DMRT3
DOCK2
ECE1
EFEMP2
EIF4E2
ENKD1
EPDR1
FADS6
FAH
FAM110A
FAM161A
FAM221B
FAM27E3
FAM71C
FAM74A4
FAM76B
FAM90A1
FARS2
FBXO34
FBXW5
FEZF1
FOXB1
FRS3
FTHL17
FZD10
GEM
GFOD1
GLIDR
GLP1R
GLRX3
GLYAT
GNAI2
GNE
GOLGA8EP
GPANK1
GPHB5
GPRIN2
GRN
GUCD1
HAPLN2
HCK
HHEX
HOXA1
HOXB5
HOXB9
HOXC8
HPCAL1
HS6ST1
HSD3B7
HSPA12B
HSPD1
ICAM1
IGFBP6
IGSF8
IL10
IL16
IL2RG
INO80B
INTS5
IP6K3
ITGB2
ITGB4
ITGB5
JOSD1
JPH3
KLHL38
KLK8
KPRP
KRT20
KRT83
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-10
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-9
KRTAP11-1
KRTAP12-1
KRTAP12-2
KRTAP12-3
KRTAP15-1
KRTAP17-1
KRTAP19-7
KRTAP3-1
KRTAP3-2
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP4-4
KRTAP4-5
KRTAP4-7
KRTAP5-11
KRTAP5-2
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LAGE3
LASP1
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LELP1
LENG1
LINC00656
LMF2
LNX1
LRCH4
LRFN4
LUZP4
LYVE1
MACROH2A1
MAPKBP1
MATN3
MEIS2
MELTF
MEOX2
MLLT6
MOBP
MTA1
MUL1
MXI1
MYPOP
NAB2
NAXD
NBPF19
NECTIN2
NECTIN3
NEK6
NKD1
NOTCH2NLA
NPDC1
NR1D2
NR4A3
NTN4
NUFIP2
OLIG3
OPCML
OTX1
P2RX7
P2RY6
PAX5
PCED1A
PCSK5
PDE9A
PDIA4
PGAP6
PGLS
PHLDA1
PIGS
PIN1
PKD2
PLSCR4
POM121L8P
POU1F1
POU4F2
PRKAB2
PRPF31
PRR13
PRR19
PTGER3
PTK7
PTPMT1
PTPRH
PVR
QPRT
R3HDM2
RAB19
RAB3A
RALGDS
RANBP3
RASD1
RECK
RGL2
RHBDL1
RHNO1
RNF38
RNF8
RPS19BP1
RPS28
RTN4RL1
SCARF1
SCNM1
SEMA3B
SH3GLB2
SHFL
SLC13A5
SLC22A23
SLC23A1
SLC25A10
SLC25A31
SLC25A42
SLC6A20
SLIT1
SMARCE1
SMCP
SMG9
SMOC1
SPACA9
SPAG8
SPATA24
SPATA3
SPRY1
SPRY2
SSC4D
STK16
SUSD2
SUSD6
SUV39H1
TACSTD2
TAPBPL
TBC1D16
TBC1D23
TCAF1
TCEA2
TCEANC
TFAP2D
TGFB1
THAP10
THAP7
TIE1
TLE5
TMEM140
TMEM150A
TMIE
TNIP3
TNP2
TNPO3
TNS2
TRIM41
TRIM42
TRPV6
TSPAN4
TTC23
TXNDC5
TYMSOS
TYRO3
UBL5
UTP23
UXT
VASN
VENTX
VEZF1
VGLL3
VPS11
VWC2
VWC2L
WIF1
WNT11
WT1
WT1-AS
YIPF3
YY1
ZBTB24
ZBTB25
ZDHHC1
ZFYVE21
ZIC1
ZNF101
ZNF107
ZNF121
ZNF124
ZNF138
ZNF165
ZNF20
ZNF23
ZNF250
ZNF264
ZNF266
ZNF319
ZNF32
ZNF330
ZNF408
ZNF414
ZNF417
ZNF439
ZNF440
ZNF444
ZNF473
ZNF490
ZNF491
ZNF497
ZNF524
ZNF559
ZNF572
ZNF575
ZNF578
ZNF580
ZNF581
ZNF587
ZNF625
ZNF648
ZNF669
ZNF696
ZNF697
ZNF775
ZNF786
ZNF79
ZNF792
ZNF837
ZSCAN12
ZSCAN21
21 interacting genes:
ACTN2
CD2AP
CYSRT1
DIAPH1
HAX1
HSF2BP
KRT40
KRTAP10-3
KRTAP10-8
KRTAP6-2
LMNA
MAGEA8
MDFI
PACS1
PACS2
PKD1
PLSCR1
PTPRG
TNNI3
TPM1
TRPC1
Entrez ID
386681
5311
HPRD ID
11194
01437
Ensembl ID
ENSG00000187766
ENSG00000118762
Uniprot IDs
P60410
Q13563
Q9UEU6
PDB IDs
2KLD
2KLE
2KQ6
2Y4Q
3HRN
3HRO
5K47
5MKE
5MKF
5T4D
6A70
6D1W
6T9N
6T9O
6WB8
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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