FDFT1 and ELP4

Data Source:
BioGRID (biochemical)

		FDFT1	ELP4
Description		farnesyl-diphosphate farnesyltransferase 1	elongator acetyltransferase complex subunit 4
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleoplasm Cytoplasm Transcription Elongation Factor Complex Elongator Holoenzyme Complex
	Molecular Function	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity	RNA Polymerase II Complex Binding Protein Binding Phosphorylase Kinase Regulator Activity
	Biological Process	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process	TRNA Wobble Uridine Modification Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Regulation Of Protein Kinase Activity
Pathways		Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)	HATs acetylate histones
Drugs		TAK-475
Diseases
GWAS		Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Platelet count ( 32888494) Polycystic ovary syndrome ( 26284813) Processed meat consumption ( 32066663) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Glaucoma ( 25027321) Mental health study participation (completed survey) ( 31263887) Optic disc area ( 25631615) Optic disc size ( 31809533) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		25 interacting genes: ANXA5 AQP6 ARL13B ARL6IP1 CD74 CD79A CLN5 CREB3 ELOVL4 FAM209A GJA8 GPR152 ITGB5 JAGN1 LMNA NCAPH2 PANX1 RFLNA RUVBL2 SHPRH SLC10A1 SLC35C2 TLCD4 TMEM43 TMX2	2 interacting genes: HINFP PPP1CC
Entrez ID		2222	26610
HPRD ID		01694	07377
Ensembl ID		ENSG00000079459	ENSG00000109911
Uniprot IDs		A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1	G5E9D4 Q96EB1
PDB IDs		1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA 6PYJ 6PYV 6PYW 6PZ5
Enriched GO Terms of Interacting Partners?
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