TMPRSS6 and LAMA1

Data Source:
HPRD (in vitro)

		TMPRSS6	LAMA1
Description		transmembrane serine protease 6	laminin subunit alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Membrane	Extracellular Region Basement Membrane Laminin-1 Complex Laminin-3 Complex Extracellular Space Cell-cell Junction Membrane Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding	Signaling Receptor Binding Extracellular Matrix Structural Constituent Protein Binding Protein C-terminus Binding Glycosphingolipid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Iron Ion Homeostasis Extracellular Matrix Disassembly Negative Regulation Of BMP Signaling Pathway Collagen Catabolic Process Membrane Protein Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Iron Ion Homeostasis Self Proteolysis	Morphogenesis Of An Epithelial Sheet Protein Phosphorylation Cell Adhesion Cell Surface Receptor Signaling Pathway Axon Guidance Animal Organ Morphogenesis Tissue Development Regulation Of Cell Adhesion Extracellular Matrix Organization Regulation Of Cell Migration Camera-type Eye Development Establishment Of Epithelial Cell Apical/basal Polarity Regulation Of Embryonic Development Blood Vessel Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Branching Involved In Salivary Gland Morphogenesis Retinal Blood Vessel Morphogenesis
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans L1CAM interactions MET activates PTK2 signaling
Drugs			Lanoteplase
Diseases
GWAS		Blood protein levels ( 29875488) Clinical laboratory measurements ( 27897004) Glycated hemoglobin levels ( 20858683 31213470 28898252) Hematocrit ( 29403010 32888494 28453575 27863252 28017375 19862010) Hematological and biochemical traits ( 31902109 20139978) Hematological parameters ( 19820697) Hematology traits ( 23263863) Hemoglobin ( 29403010 19820698 32888494 28453575 19862010) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693 28017375) Hepcidin levels ( 21785125) Hepcidin/ferritin ratio ( 27846281) Hepcidin/transferrin saturation ratio ( 27846281) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494 27863252) Iron levels ( 19880490) Iron status biomarkers ( 21149283 21208937 19820699 19084217) Iron status biomarkers (ferritin levels) ( 28334935 25352340) Iron status biomarkers (iron levels) ( 28334935 25352340) Iron status biomarkers (transferrin levels) ( 25352340) Iron status biomarkers (transferrin saturation) ( 28334935 25352340) LDL cholesterol ( 30275531) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 23263863 29403010 32888494 19853236 28453575 20139978 27863252 28017375 19862010 28031487) Mean corpuscular hemoglobin concentration ( 23263863 29403010 32888494 28453575 20139978 27863252 28017375) Mean corpuscular volume ( 23263863 29403010 31194788 32888494 19853236 28453575 20139978 27863252 28017375 19862010) Mean spheric corpuscular volume ( 32888494) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494 27863252) Red blood cell traits ( 20927387 23935956 23222517) Red cell distribution width ( 32888494 27863252 28957414) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252) Total bilirubin levels ( 29403010) Triglyceride levels ( 32203549 32154731)	Adverse response to drug ( 30420678) Response to citalopram treatment ( 22760553) Type 2 diabetes ( 30054458 22693455 30297969 32499647)
Interacting Genes		3 interacting genes: COL1A1 FN1 LAMA1	20 interacting genes: ACHE APCS APP C3 COL7A1 DAG1 FBLN2 HSPG2 ITGA1 ITGA2 ITGB1 MEP1A NID1 NT5E PLAT PLG SAA1 SAA2 TMPRSS6 UBC
Entrez ID		164656	284217
HPRD ID		10270	01033
Ensembl ID		ENSG00000187045	ENSG00000101680
Uniprot IDs		Q8IU80	P25391
PDB IDs
Enriched GO Terms of Interacting Partners?
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