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AHCYL1 and PLEKHG5
Data Source:
BioGRID
(two hybrid)
AHCYL1
PLEKHG5
Description
adenosylhomocysteinase like 1
pleckstrin homology and RhoGEF domain containing G5
Image
No pdb structure
GO Annotations
Cellular Component
Cytoplasm
Endoplasmic Reticulum Membrane
Cytosol
Apical Plasma Membrane
Mitochondria-associated Endoplasmic Reticulum Membrane
Extracellular Exosome
Cytoplasm
Cytosol
Plasma Membrane
Cell-cell Junction
Lamellipodium
Endocytic Vesicle
Axon
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
Adenosylhomocysteinase Activity
Protein Binding
Identical Protein Binding
Biological Process
MRNA Polyadenylation
Protein Export From Nucleus
One-carbon Metabolic Process
Apoptotic Process
Positive Regulation Of Sodium Ion Transport
Regulation Of MRNA 3'-end Processing
Regulation Of Ion Transmembrane Transporter Activity
S-adenosylmethionine Cycle
Angiotensin-activated Signaling Pathway
Epithelial Fluid Transport
Regulation Of Anion Transport
Response To Calcium Ion
Regulation Of Cardiac Conduction
Mitochondrion-endoplasmic Reticulum Membrane Tethering
G Protein-coupled Receptor Signaling Pathway
Rho Protein Signal Transduction
Endothelial Cell Chemotaxis
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Regulation Of Catalytic Activity
Regulation Of Small GTPase Mediated Signal Transduction
Pathways
PLC beta mediated events
DAG and IP3 signaling
Role of phospholipids in phagocytosis
FCERI mediated Ca+2 mobilization
Regulation of insulin secretion
VEGFR2 mediated cell proliferation
Ion homeostasis
Ion homeostasis
CLEC7A (Dectin-1) induces NFAT activation
FCGR3A-mediated IL10 synthesis
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events
Drugs
Diseases
Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS
Height (
31562340
)
Multiple sclerosis (
24076602
)
QT interval (
19305408
)
Interacting Genes
25 interacting genes:
BID
CDKN2C
DACH1
GEM
HBQ1
HEXIM2
HGS
HSPA6
ITPR1
JOSD2
LRRK2
MEOX2
MFHAS1
PLEKHG5
PPL
PRDM6
PSMD9
RNF6
SLC23A1
SOX30
SRPK1
SRPK2
SUMO2
UACA
ZNF165
1 interacting genes:
AHCYL1
Entrez ID
10768
57449
HPRD ID
07613
11104
Ensembl ID
ENSG00000168710
ENSG00000171680
Uniprot IDs
A0A024R0A8
O43865
O94827
PDB IDs
3MTG
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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