VPS26C and CD55

Data Source:
BioGRID (proximity labelling technology)

		VPS26C	CD55
Description		VPS26 endosomal protein sorting factor C	CD55 molecule (Cromer blood group)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endosome	Golgi Membrane Extracellular Region Plasma Membrane Cell Surface Transport Vesicle Secretory Granule Membrane Anchored Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Membrane Raft Extracellular Exosome Ficolin-1-rich Granule Membrane
	Molecular Function	Molecular_function Protein Binding	Virus Receptor Activity Protein Binding Lipid Binding
	Biological Process	Intracellular Protein Transport Endocytic Recycling Retrograde Transport, Endosome To Plasma Membrane	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Complement Activation, Classical Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Complement Activation Regulation Of Lipopolysaccharide-mediated Signaling Pathway CD4-positive, Alpha-beta T Cell Cytokine Production Neutrophil Degranulation Innate Immune Response Respiratory Burst Negative Regulation Of Complement Activation Viral Entry Into Host Cell Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of CD4-positive, Alpha-beta T Cell Activation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation
Pathways			Class B/2 (Secretin family receptors) Neutrophil degranulation COPI-mediated anterograde transport Regulation of Complement cascade
Drugs			Chloramphenicol
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
GWAS			Blood protein levels ( 29875488 28240269) Refractive error ( 32231278) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		14 interacting genes: CBLB DECR2 INCA1 LRIF1 MAML3 MAPK6 MDM4 MEI4 MEOX2 PTPN21 RAB39B TEPSIN XPA ZNF655	6 interacting genes: ADGRE5 CD14 CR1 FYN GPLD1 LCK
Entrez ID		10311	1604
HPRD ID		10390	00500
Ensembl ID		ENSG00000157538	ENSG00000196352
Uniprot IDs		A8MTY9 A8MY26 O14972	B1AP13 P08174
PDB IDs			1H03 1H04 1H2P 1H2Q 1M11 1NWV 1OJV 1OJW 1OJY 1OK1 1OK2 1OK3 1OK9 1UOT 1UPN 2C8I 2QZD 2QZF 2QZH 3IYP 3J24 5FOA 6ILJ 6ILK 6LA5 7C9W
Enriched GO Terms of Interacting Partners?
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