SRPK2 - HiPPIP

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ABL1	ABL proto-oncogene 1, non-receptor tyrosine kinase	Regulation of actin dynamics for phagocytic cup formation Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Myogenesis Myogenesis RHO GTPases Activate WASPs and WAVEs HDR through Single Strand Annealing (SSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Cyclin D associated events in G1 RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX2 regulates osteoblast differentiation FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	ATP Imatinib Dasatinib N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide Nilotinib XL228 Bosutinib 2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE 1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA Myristic acid PD-166326 5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE 2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide Regorafenib Ponatinib Fostamatinib Brigatinib Radotinib
ACIN1	apoptotic chromatin condensation inducer 1	Apoptotic cleavage of cellular proteins
ACTB	actin beta	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation HATs acetylate histones Prefoldin mediated transfer of substrate to CCT/TriC Folding of actin by CCT/TriC EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions B-WICH complex positively regulates rRNA expression RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation UCH proteinases DNA Damage Recognition in GG-NER Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOF GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production	Quercetin Phenethyl Isothiocyanate
ACTG1	actin gamma 1	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Copper Artenimol
ADAMTS18	ADAM metallopeptidase with thrombospondin type 1 motif 18	Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
ADGRG5	adhesion G protein-coupled receptor G5
ADPRH	ADP-ribosylarginine hydrolase
AHCYL1	adenosylhomocysteinase like 1	PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
AKAP13	A-kinase anchoring protein 13	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
AKT1	AKT serine/threonine kinase 1	Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Translocation of SLC2A4 (GLUT4) to the plasma membrane Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation MTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling	ATP Arsenic trioxide Genistein Inositol 1,3,4,5-Tetrakisphosphate Resveratrol Archexin Enzastaurin Perifosine N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
ALDOA	aldolase, fructose-bisphosphate A	Platelet degranulation Neutrophil degranulation Glycolysis Gluconeogenesis	Zinc 1,6-Fructose Diphosphate (Linear Form) Dihydroxyacetone phosphate 1,6-DI-O-PHOSPHONO-D-MANNITOL N-(4-CHLOROPHENYL)-3-(PHOSPHONOOXY)NAPHTHALENE-2-CARBOXAMIDE Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
ALKBH3	alkB homolog 3, alpha-ketoglutarate dependent dioxygenase	ALKBH3 mediated reversal of alkylation damage	Ascorbic acid
ALPL	alkaline phosphatase, biomineralization associated	Post-translational modification: synthesis of GPI-anchored proteins	Mersalyl
AMER1	APC membrane recruitment protein 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex
AMMECR1L	AMMECR1 like
ANK3	ankyrin 3	Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport
ANKFY1	ankyrin repeat and FYVE domain containing 1	RHOD GTPase cycle
ANKRD35	ankyrin repeat domain 35
AP1M1	adaptor related protein complex 1 subunit mu 1	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
APEX1	apurinic/apyrimidinic endodeoxyribonuclease 1	Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)	Lucanthone
APOBEC3C	apolipoprotein B mRNA editing enzyme catalytic subunit 3C	mRNA Editing: C to U Conversion Formation of the Editosome
APP	amyloid beta precursor protein	Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation	Deferoxamine Aluminium Zinc L-methionine (R)-S-oxide Resveratrol Tromethamine Phenserine Tetrathiomolybdate CAD106 Mito-4509 Edonerpic Dimercaprol Copper Florbetaben (18F) Florbetapir (18F) Flutemetamol (18F) Zinc acetate Aluminium phosphate Aluminum acetate Zinc chloride Zinc sulfate, unspecified form
ARFGEF3	ARFGEF family member 3
ARGLU1	arginine and glutamate rich 1
ARHGAP12	Rho GTPase activating protein 12	RAC1 GTPase cycle RHOD GTPase cycle RHOV GTPase cycle RHOF GTPase cycle
ARL6IP4	ADP ribosylation factor like GTPase 6 interacting protein 4
ARPC1B	actin related protein 2/3 complex subunit 1B	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
ARPC3	actin related protein 2/3 complex subunit 3	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
ARSG	arylsulfatase G	Glycosphingolipid metabolism The activation of arylsulfatases
ASL	argininosuccinate lyase	Urea cycle	Arginine Argininosuccinate 2-(N-morpholino)ethanesulfonic acid
ATAT1	alpha tubulin acetyltransferase 1	Cilium Assembly
AURKA	aurora kinase A	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition SUMOylation of DNA replication proteins TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA	Phosphonothreonine AT9283 CYC116 Alisertib SNS-314 Cenisertib Enzastaurin 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE AKI-001 1-{5-[2-(thieno[3,2-d]pyrimidin-4-ylamino)ethyl]-1,3-thiazol-2-yl}-3-[3-(trifluoromethyl)phenyl]urea 1-(5-{2-[(1-methyl-1H-pyrazolo[4,3-d]pyrimidin-7-yl)amino]ethyl}-1,3-thiazol-2-yl)-3-[3-(trifluoromethyl)phenyl]urea N-{3-[(4-{[3-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-2-YL)AMINO]PHENYL}CYCLOPROPANECARBOXAMIDE N-butyl-3-{[6-(9H-purin-6-ylamino)hexanoyl]amino}benzamide 2-(1H-pyrazol-3-yl)-1H-benzimidazole N-[3-(1H-BENZIMIDAZOL-2-YL)-1H-PYRAZOL-4-YL]BENZAMIDE Fostamatinib MLN8054
BAG3	BAG cochaperone 3	Regulation of HSF1-mediated heat shock response
BAIAP2	BAR/IMD domain containing adaptor protein 2	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
BAZ1A	bromodomain adjacent to zinc finger domain 1A
BCL9L	BCL9 like	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
BCLAF1	BCL2 associated transcription factor 1
BUD13	BUD13 homolog
C16orf78	chromosome 16 open reading frame 78
C18orf25	chromosome 18 open reading frame 25
C1orf35	chromosome 1 open reading frame 35	Neutrophil degranulation
C4orf46	chromosome 4 open reading frame 46
CACNG2	calcium voltage-gated channel auxiliary subunit gamma 2	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions	Ergocalciferol Enflurane Spironolactone Ethanol Butamben Bioallethrin
CADPS2	calcium dependent secretion activator 2		Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
CALCOCO1	calcium binding and coiled-coil domain 1
CAMSAP1	calmodulin regulated spectrin associated protein 1
CAND1	cullin associated and neddylation dissociated 1	Neutrophil degranulation Neddylation Iron uptake and transport
CARD11	caspase recruitment domain family member 11	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
CARHSP1	calcium regulated heat stable protein 1
CASK	calcium/calmodulin dependent serine protein kinase	Dopamine Neurotransmitter Release Cycle Syndecan interactions Nephrin family interactions Neurexins and neuroligins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea	Formic acid Fostamatinib
CBLN4	cerebellin 4 precursor
CBX5	chromobox 5	SUMOylation of chromatin organization proteins Transcriptional Regulation by E2F6 Factors involved in megakaryocyte development and platelet production	Copper
CCDC28A	coiled-coil domain containing 28A
CCDC86	coiled-coil domain containing 86
CCDC88B	coiled-coil domain containing 88B
CCDC97	coiled-coil domain containing 97
CCM2	CCM2 scaffold protein
CDC42EP4	CDC42 effector protein 4	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle
CDK12	cyclin dependent kinase 12	TP53 Regulates Transcription of DNA Repair Genes
CDK13	cyclin dependent kinase 13	TP53 Regulates Transcription of DNA Repair Genes Neutrophil degranulation
CDK7	cyclin dependent kinase 7	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs	Phosphonothreonine Alvocidib SNS-032 Seliciclib
CEP170	centrosomal protein 170
CHD1L	chromodomain helicase DNA binding protein 1 like	Formation of Incision Complex in GG-NER Dual Incision in GG-NER
CHD2	chromodomain helicase DNA binding protein 2
CHEK2	checkpoint kinase 2	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	XL844 Enzastaurin Fostamatinib
CHERP	calcium homeostasis endoplasmic reticulum protein	mRNA Splicing - Major Pathway
CHTOP	chromatin target of PRMT1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
CHUK	component of inhibitor of nuclear factor kappa B kinase complex	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 AKT phosphorylates targets in the cytosol Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Constitutive Signaling by AKT1 E17K in Cancer NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	Aminosalicylic acid Mesalazine Sulfasalazine Acetylcysteine
CLASP1	cytoplasmic linker associated protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Role of ABL in ROBO-SLIT signaling Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation	Fostamatinib
CLASP2	cytoplasmic linker associated protein 2	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Role of ABL in ROBO-SLIT signaling RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
CLASRP	CLK4 associating serine/arginine rich protein
CLCNKA	chloride voltage-gated channel Ka	Stimuli-sensing channels	Niflumic acid Talniflumate
CLDN19	claudin 19	Tight junction interactions
CLK1	CDC like kinase 1		Debromohymenialdisine CHGN111 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
CLK2	CDC like kinase 2		Fostamatinib
CLK3	CDC like kinase 3		K-00546 ethyl 3-[(E)-2-amino-1-cyanoethenyl]-6,7-dichloro-1-methyl-1H-indole-2-carboxylate Fostamatinib
CLU	clusterin	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
COIL	coilin
CPLANE1	ciliogenesis and planar polarity effector 1
CPSF7	cleavage and polyadenylation specific factor 7	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs RHOBTB1 GTPase cycle
CRTC1	CREB regulated transcription coactivator 1	Transcriptional activation of mitochondrial biogenesis Circadian Clock Heme signaling
CSAG1	chondrosarcoma associated gene 1
CTNNBL1	catenin beta like 1	mRNA Splicing - Major Pathway
CXADR	CXADR Ig-like cell adhesion molecule	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
DAW1	dynein assembly factor with WD repeats 1
DBF4B	DBF4 zinc finger B
DCAF10	DDB1 and CUL4 associated factor 10	Neddylation
DDX21	DExD-box helicase 21	B-WICH complex positively regulates rRNA expression Major pathway of rRNA processing in the nucleolus and cytosol
DDX39B	DExD-box helicase 39B	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle	Artenimol
DDX3X	DEAD-box helicase 3 X-linked	Neutrophil degranulation
DDX46	DEAD-box helicase 46	mRNA Splicing - Major Pathway
DDX50	DExD-box helicase 50
DDX6	DEAD-box helicase 6	mRNA decay by 5' to 3' exoribonuclease	D-tartaric acid
DHX8	DEAH-box helicase 8
DIDO1	death inducer-obliterator 1
DNAH6	dynein axonemal heavy chain 6
DNAH9	dynein axonemal heavy chain 9
DNAJC8	DnaJ heat shock protein family (Hsp40) member C8	mRNA Splicing - Major Pathway
DOCK3	dedicator of cytokinesis 3	RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle NTRK2 activates RAC1 NTRK2 activates RAC1 Factors involved in megakaryocyte development and platelet production
DRAP1	DR1 associated protein 1	Signaling by NODAL Signaling by Activin
DRG1	developmentally regulated GTP binding protein 1
ECT2	epithelial cell transforming 2	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle
EED	embryonic ectoderm development	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events Defective pyroptosis
EFCAB12	EF-hand calcium binding domain 12
EGLN2	egl-9 family hypoxia inducible factor 2	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Ascorbic acid Roxadustat
EIF1AY	eukaryotic translation initiation factor 1A Y-linked
EIF3A	eukaryotic translation initiation factor 3 subunit A	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4B	eukaryotic translation initiation factor 4B	L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4G1	eukaryotic translation initiation factor 4 gamma 1	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression mTORC1-mediated signalling Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
ELAVL3	ELAV like RNA binding protein 3
ELP6	elongator acetyltransferase complex subunit 6	HATs acetylate histones
ENOX2	ecto-NOX disulfide-thiol exchanger 2		Idronoxil
ENSA	endosulfine alpha	MASTL Facilitates Mitotic Progression MASTL Facilitates Mitotic Progression
EPB41L1	erythrocyte membrane protein band 4.1 like 1	Trafficking of AMPA receptors Neurexins and neuroligins Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
EPB41L4A	erythrocyte membrane protein band 4.1 like 4A
EPB41L4B	erythrocyte membrane protein band 4.1 like 4B
EPM2A	EPM2A glucan phosphatase, laforin	Glycogen synthesis Myoclonic epilepsy of Lafora
EPS8L1	EPS8 like 1
EPS8L3	EPS8 like 3
ERBB3	erb-b2 receptor tyrosine kinase 3		Tucatinib
ERC1	ELKS/RAB6-interacting/CAST family member 1
ERCC3	ERCC excision repair 3, TFIIH core complex helicase subunit	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Tat-mediated elongation of the HIV-1 transcript NoRC negatively regulates rRNA expression Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE
ERN1	endoplasmic reticulum to nucleus signaling 1	IRE1alpha activates chaperones IRE1alpha activates chaperones	N~2~-1H-benzimidazol-5-yl-N~4~-(3-cyclopropyl-1H-pyrazol-5-yl)pyrimidine-2,4-diamine Fostamatinib
EVI5L	ecotropic viral integration site 5 like
F5	coagulation factor V	Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation	Drotrecogin alfa Thrombomodulin Alfa Thrombin Protein C Human thrombin Thrombin alfa Protein S human Anti-inhibitor coagulant complex
FAM43A	family with sequence similarity 43 member A
FAM76B	family with sequence similarity 76 member B
FAM90A1	family with sequence similarity 90 member A1
FBXO24	F-box protein 24
FCHO1	FCH and mu domain containing endocytic adaptor 1	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
FGF12	fibroblast growth factor 12	Phase 0 - rapid depolarisation
FGFR3	fibroblast growth factor receptor 3	Signaling by activated point mutants of FGFR3 FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer	XL999 Pazopanib Ponatinib Lenvatinib Nintedanib Fostamatinib Erdafitinib Pemigatinib Selpercatinib
FIP1L1	factor interacting with PAPOLA and CPSF1	Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins
FMNL1	formin like 1	RHO GTPases Activate Formins RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle
FOXN3	forkhead box N3
FXR1	FMR1 autosomal homolog 1	Signaling by BRAF and RAF1 fusions
GABARAP	GABA type A receptor-associated protein	Macroautophagy TBC/RABGAPs
GABARAPL1	GABA type A receptor associated protein like 1	Macroautophagy
GBF1	golgi brefeldin A resistant guanine nucleotide exchange factor 1	trans-Golgi Network Vesicle Budding VxPx cargo-targeting to cilium COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
GCC2	GRIP and coiled-coil domain containing 2	Retrograde transport at the Trans-Golgi-Network Signaling by ALK fusions and activated point mutants
GGCX	gamma-glutamyl carboxylase	Gamma-carboxylation of protein precursors Gamma-carboxylation of protein precursors Defective gamma-carboxylation of F9	Coagulation factor VIIa Recombinant Human Coagulation Factor IX (Recombinant) Glutamic acid Menadione Phylloquinone Anisindione Kappadione Coagulation Factor IX Human
GHR	growth hormone receptor	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Somatotropin Pegvisomant Somatrem Somapacitan
GLRA4	glycine receptor alpha 4 (pseudogene)
GNGT2	G protein subunit gamma transducin 2	Activation of G protein gated Potassium channels G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GSE1	Gse1 coiled-coil protein
GTF2E1	general transcription factor IIE subunit 1	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
GTPBP4	GTP binding protein 4
GXYLT2	glucoside xylosyltransferase 2
H2BC12	H2B clustered histone 12	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape E3 ubiquitin ligases ubiquitinate target proteins RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation
HBS1L	HBS1 like translational GTPase	mRNA decay by 3' to 5' exoribonuclease
HERC3	HECT and RLD domain containing E3 ubiquitin protein ligase 3	Antigen processing: Ubiquitination & Proteasome degradation
HIRIP3	HIRA interacting protein 3
HIVEP1	HIVEP zinc finger 1
HMCN2	hemicentin 2
HMGA1	high mobility group AT-hook 1	Integration of provirus 2-LTR circle formation Integration of viral DNA into host genomic DNA Autointegration results in viral DNA circles APOBEC3G mediated resistance to HIV-1 infection Vpr-mediated nuclear import of PICs Formation of Senescence-Associated Heterochromatin Foci (SAHF)
HMGN2	high mobility group nucleosomal binding domain 2
HMGN3	high mobility group nucleosomal binding domain 3
HMGXB4	HMG-box containing 4
HNRNPA1	heterogeneous nuclear ribonucleoprotein A1	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
HNRNPA3	heterogeneous nuclear ribonucleoprotein A3	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
HNRNPC	heterogeneous nuclear ribonucleoprotein C	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
HNRNPK	heterogeneous nuclear ribonucleoprotein K	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA HCMV Late Events	Artenimol Phenethyl Isothiocyanate
HOMER3	homer scaffold protein 3	Neurexins and neuroligins Neurexins and neuroligins
HOXB6	homeobox B6
HTATSF1	HIV-1 Tat specific factor 1
IFIT5	interferon induced protein with tetratricopeptide repeats 5	Interferon alpha/beta signaling
IRS2	insulin receptor substrate 2	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
ISLR	immunoglobulin superfamily containing leucine rich repeat	Platelet degranulation
JMJD1C	jumonji domain containing 1C	Factors involved in megakaryocyte development and platelet production
KANK2	KN motif and ankyrin repeat domains 2
KCNN2	potassium calcium-activated channel subfamily N member 2	Ca2+ activated K+ channels Acetylcholine inhibits contraction of outer hair cells	Procaine Miconazole Trimebutine
KHDRBS1	KH RNA binding domain containing, signal transduction associated 1	PTK6 Regulates Proteins Involved in RNA Processing
KIF11	kinesin family member 11	MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins	3-[(5s)-1-Acetyl-3-(2-Chlorophenyl)-4,5-Dihydro-1h-Pyrazol-5-Yl]Phenol Monastrol Filanesib (4R)-4-(3-HYDROXYPHENYL)-N,N,7,8-TETRAMETHYL-3,4-DIHYDROISOQUINOLINE-2(1H)-CARBOXAMIDE N,N-DIETHYL-2-[(2-THIENYLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE (5R)-N,N-DIETHYL-5-METHYL-2-[(THIOPHEN-2-YLCARBONYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXAMIDE MK-0731 [(4R)-4-(3-HYDROXYPHENYL)-1,6-DIMETHYL-2-THIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL](PHENYL)METHANONE (2S)-4-(2,5-DIFLUOROPHENYL)-N-METHYL-2-PHENYL-N-PIPERIDIN-4-YL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (1S)-1-CYCLOPROPYL-2-[(2S)-4-(2,5-DIFLUOROPHENYL)-2-PHENYL-2,5-DIHYDRO-1H-PYRROL-1-YL]-2-OXOETHANAMINE (2S)-4-(2,5-DIFLUOROPHENYL)-N,N-DIMETHYL-2-PHENYL-2,5-DIHYDRO-1H-PYRROLE-1-CARBOXAMIDE (5S)-5-(3-AMINOPROPYL)-3-(2,5-DIFLUOROPHENYL)-N-ETHYL-5-PHENYL-4,5-DIHYDRO-1H-PYRAZOLE-1-CARBOXAMIDE
KRT78	keratin 78	Keratinization Formation of the cornified envelope
KXD1	KxDL motif containing 1
LBR	lamin B receptor	Cholesterol biosynthesis Initiation of Nuclear Envelope (NE) Reformation RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Regulation of MECP2 expression and activity
LCA5	lebercilin LCA5
LCE3D	late cornified envelope 3D	Formation of the cornified envelope
LDHC	lactate dehydrogenase C	Pyruvate metabolism	NADH
LGMN	legumain	Trafficking and processing of endosomal TLR Vitamin D (calciferol) metabolism MHC class II antigen presentation
LINC00322	long intergenic non-protein coding RNA 322
LMNA	lamin A/C	XBP1(S) activates chaperone genes Signaling by BRAF and RAF1 fusions
LMNB1	lamin B1	Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation RHOD GTPase cycle RHOF GTPase cycle
LMO7	LIM domain 7	Neddylation Signaling by ALK fusions and activated point mutants Antigen processing: Ubiquitination & Proteasome degradation
LRRC34	leucine rich repeat containing 34
LRRC52	leucine rich repeat containing 52	Sensory processing of sound by inner hair cells of the cochlea
LRRN4CL	LRRN4 C-terminal like
LUC7L3	LUC7 like 3 pre-mRNA splicing factor
LUZP4	leucine zipper protein 4	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
MAB21L2	mab-21 like 2
MACF1	microtubule actin crosslinking factor 1
MACO1	macoilin 1	RHOA GTPase cycle RHOC GTPase cycle
MAGEB1	MAGE family member B1
MAP1S	microtubule associated protein 1S
MAP3K20	mitogen-activated protein kinase kinase kinase 20		Dasatinib Fostamatinib
MAP4	microtubule associated protein 4		Paclitaxel Docetaxel Artenimol
MAP7	microtubule associated protein 7
MAP7D1	MAP7 domain containing 1
MAPKAPK3	MAPK activated protein kinase 3	p38MAPK events Oxidative Stress Induced Senescence VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation	2-[2-(2-FLUOROPHENYL)PYRIDIN-4-YL]-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE 2-(2-QUINOLIN-3-YLPYRIDIN-4-YL)-1,5,6,7-TETRAHYDRO-4H-PYRROLO[3,2-C]PYRIDIN-4-ONE
MAPKAPK5	MAPK activated protein kinase 5	Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation	Fostamatinib
MAPRE1	microtubule associated protein RP/EB family member 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
MAPT	microtubule associated protein tau	Caspase-mediated cleavage of cytoskeletal proteins	Lansoprazole Astemizole Paclitaxel Docetaxel Flortaucipir F-18
MARCHF10	membrane associated ring-CH-type finger 10
MAST2	microtubule associated serine/threonine kinase 2
MATR3	matrin 3
MCOLN3	mucolipin TRP cation channel 3	TRP channels
MDC1	mediator of DNA damage checkpoint 1	SUMOylation of DNA damage response and repair proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends TP53 Regulates Transcription of DNA Repair Genes G2/M DNA damage checkpoint
MDK	midkine	Signaling by ALK Signaling by ALK NOTCH2 Activation and Transmission of Signal to the Nucleus
MFSD10	major facilitator superfamily domain containing 10
MIB2	MIB E3 ubiquitin protein ligase 2	Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus Antigen processing: Ubiquitination & Proteasome degradation
MIPOL1	mirror-image polydactyly 1
MMP23B	matrix metallopeptidase 23B		Marimastat
MPP3	MAGUK p55 scaffold protein 3
MRPS6	mitochondrial ribosomal protein S6	Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination
MTCL1	microtubule crosslinking factor 1
MYCBP2	MYC binding protein 2
MYLIP	myosin regulatory light chain interacting protein	VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
MYO18B	myosin XVIIIB
MYO1E	myosin IE		Imidazole
MZT2B	mitotic spindle organizing protein 2B	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
NADK	NAD kinase	Nicotinate metabolism
NAGK	N-acetylglucosamine kinase	Synthesis of UDP-N-acetyl-glucosamine	N-Acetylglucosamine
NCBP3	nuclear cap binding subunit 3
NCK2	NCK adaptor protein 2	Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching RHOU GTPase cycle RHOV GTPase cycle
NCL	nucleolin	Major pathway of rRNA processing in the nucleolus and cytosol
NELFE	negative elongation factor complex member E	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
NGDN	neuroguidin
NGLY1	N-glycanase 1	N-glycan trimming in the ER and Calnexin/Calreticulin cycle
NKAP	NFKB activating protein
NOLC1	nucleolar and coiled-body phosphoprotein 1		Doxorubicin
NOM1	nucleolar protein with MIF4G domain 1
NOP16	NOP16 nucleolar protein
NOP53	NOP53 ribosome biogenesis factor
NPM2	nucleophosmin/nucleoplasmin 2
NSMCE4A	NSE4 homolog A, SMC5-SMC6 complex component	SUMOylation of DNA damage response and repair proteins
NSRP1	nuclear speckle splicing regulatory protein 1
NSUN5P2	NSUN5 pseudogene 2
NTHL1	nth like DNA glycosylase 1	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
NUP50	nucleoporin 50	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events
NXF1	nuclear RNA export factor 1	Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript
NXPE4	neurexophilin and PC-esterase domain family member 4
NXT2	nuclear transport factor 2 like export factor 2
OBI1	ORC ubiquitin ligase 1
OCEL1	occludin/ELL domain containing 1
OR10J1	olfactory receptor family 10 subfamily J member 1	Olfactory Signaling Pathway
OTOF	otoferlin	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Sensory processing of sound by inner hair cells of the cochlea
PABPC4	poly(A) binding protein cytoplasmic 4
PAK4	p21 (RAC1) activated kinase 4	Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle	Fostamatinib
PALLD	palladin, cytoskeletal associated protein
PCBP1	poly(rC) binding protein 1	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
PCF11	PCF11 cleavage and polyadenylation factor subunit	RNA polymerase II transcribes snRNA genes mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
PDCL3	phosducin like 3
PDE7B	phosphodiesterase 7B	G alpha (s) signalling events	Caffeine Trapidil
PELI1	pellino E3 ubiquitin protein ligase 1	Regulation of necroptotic cell death Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
PHF6	PHD finger protein 6
PHLDB1	pleckstrin homology like domain family B member 1
PKD1L2	polycystin 1 like 2 (gene/pseudogene)
PLEKHA5	pleckstrin homology domain containing A5	Synthesis of PIPs at the plasma membrane
PNISR	PNN interacting serine and arginine rich protein
PNMA8B	PNMA family member 8B
PNN	pinin, desmosome associated protein
POLB	DNA polymerase beta	POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway PCNA-Dependent Long Patch Base Excision Repair Ub-specific processing proteases Abasic sugar-phosphate removal via the single-nucleotide replacement pathway	Cytarabine Iron dATP (1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
POLDIP3	DNA polymerase delta interacting protein 3	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA 3'-end processing RNA Polymerase II Transcription Termination
PPHLN1	periphilin 1
PPIA	peptidylprolyl isomerase A	Platelet degranulation Uncoating of the HIV Virion Budding and maturation of HIV virion Integration of provirus Early Phase of HIV Life Cycle Minus-strand DNA synthesis Plus-strand DNA synthesis Binding and entry of HIV virion Assembly Of The HIV Virion APOBEC3G mediated resistance to HIV-1 infection Calcineurin activates NFAT Basigin interactions Neutrophil degranulation Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Cyclosporine Proline (3r)-1-Acetyl-3-Methylpiperidine Ethyl Oxo(Piperidin-1-Yl)Acetate Sanglifehrin A Copper Artenimol
PPIL1	peptidylprolyl isomerase like 1	mRNA Splicing - Major Pathway
PPP1R13L	protein phosphatase 1 regulatory subunit 13 like	Regulation of TP53 Activity through Association with Co-factors
PRKAA1	protein kinase AMP-activated catalytic subunit alpha 1	Macroautophagy Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Activation of AMPK downstream of NMDARs	Adenosine phosphate Adenosine phosphate ATP Phenformin Acetylsalicylic acid Fostamatinib Fostamatinib
PRPF38A	pre-mRNA processing factor 38A	mRNA Splicing - Major Pathway
PRPF38B	pre-mRNA processing factor 38B
PRPF40A	pre-mRNA processing factor 40 homolog A	mRNA Splicing - Major Pathway
PRPF4B	pre-mRNA processing factor 4B		Fostamatinib
PRR20A	proline rich 20A
PRR20B	proline rich 20B
PRR20C	proline rich 20C
PRR20D	proline rich 20D
PRR20E	proline rich 20E
PRRC2A	proline rich coiled-coil 2A
PRRC2B	proline rich coiled-coil 2B
PRRC2C	proline rich coiled-coil 2C
PSMA3	proteasome 20S subunit alpha 3	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation	(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Phenethyl Isothiocyanate
PSMD13	proteasome 26S subunit, non-ATPase 13	Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis ROS sensing by NFE2L2 RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
PTBP1	polypyrimidine tract binding protein 1	FGFR2 alternative splicing mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA
PTPN22	protein tyrosine phosphatase non-receptor type 22	Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse
RABEP1	rabaptin, RAB GTPase binding effector protein 1	TBC/RABGAPs
RASGRF1	Ras protein specific guanine nucleotide releasing factor 1	Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade
RBM15	RNA binding motif protein 15
RBM15B	RNA binding motif protein 15B
RBM19	RNA binding motif protein 19
RBM23	RNA binding motif protein 23
RBM8A	RNA binding motif protein 8A	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RBMX	RNA binding motif protein X-linked	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
RIPK3	receptor interacting serine/threonine kinase 3	TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis Regulation of necroptotic cell death TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 Microbial modulation of RIPK1-mediated regulated necrosis
RIT1	Ras like without CAAX 1	Signalling to p38 via RIT and RIN
RIT2	Ras like without CAAX 2	Signalling to p38 via RIT and RIN
RNF4	ring finger protein 4	Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation
RNPS1	RNA binding protein with serine rich domain 1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPL13	ribosomal protein L13	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPL22	ribosomal protein L22	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPL34	ribosomal protein L34	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPL37	ribosomal protein L37	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	(S)-3-phenyllactic acid PUROMYCIN AMINONUCLEOSIDE-5'-MONOPHOSPHATE Virginiamycin S1 Anisomycin Puromycin
RPL39L	ribosomal protein L39 like	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPL41	ribosomal protein L41	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPLP2	ribosomal protein lateral stalk subunit P2	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RPS26	ribosomal protein S26	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RRM2B	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes	Cladribine
RRP1	ribosomal RNA processing 1	Major pathway of rRNA processing in the nucleolus and cytosol
RRP1B	ribosomal RNA processing 1B
RSL1D1	ribosomal L1 domain containing 1
RSRC1	arginine and serine rich coiled-coil 1
RSRC2	arginine and serine rich coiled-coil 2
RSRP1	arginine and serine rich protein 1
RTF1	RTF1 homolog, Paf1/RNA polymerase II complex component	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
RWDD2B	RWD domain containing 2B
RXFP1	relaxin family peptide receptor 1	G alpha (s) signalling events Relaxin receptors ADORA2B mediated anti-inflammatory cytokines production
S100A4	S100 calcium binding protein A4		Trifluoperazine Copper
SAFB	scaffold attachment factor B	SUMOylation of transcription cofactors
SART1	spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP	mRNA Splicing - Major Pathway
SBK1	SH3 domain binding kinase 1		Fostamatinib
SCAF1	SR-related CTD associated factor 1
SDK2	sidekick cell adhesion molecule 2	SDK interactions
SDR42E1	short chain dehydrogenase/reductase family 42E, member 1
SEC16B	SEC16 homolog B, endoplasmic reticulum export factor	COPII-mediated vesicle transport
SEC23B	SEC23 homolog B, COPII coat complex component
SELENOS	selenoprotein S	E3 ubiquitin ligases ubiquitinate target proteins
SERPING1	serpin family G member 1	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	PPL-100 Copper
SGPL1	sphingosine-1-phosphate lyase 1	Sphingolipid de novo biosynthesis	Pyridoxal phosphate
SIPA1L3	signal induced proliferation associated 1 like 3
SLAIN2	SLAIN motif family member 2
SLC13A2	solute carrier family 13 member 2	Sodium-coupled sulphate, di- and tri-carboxylate transporters
SLC17A6	solute carrier family 17 member 6	Organic anion transporters
SLFN5	schlafen family member 5
SLTM	SAFB like transcription modulator
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1
SNIP1	Smad nuclear interacting protein 1
SNRNP27	small nuclear ribonucleoprotein U4/U6.U5 subunit 27	mRNA Splicing - Major Pathway
SNRNP35	small nuclear ribonucleoprotein U11/U12 subunit 35	mRNA Splicing - Minor Pathway
SNRNP70	small nuclear ribonucleoprotein U1 subunit 70	mRNA Splicing - Major Pathway
SNURF	SNRPN upstream open reading frame	mRNA Splicing - Major Pathway
SON	SON DNA and RNA binding protein
SPDEF	SAM pointed domain containing ETS transcription factor
SPEN	spen family transcriptional repressor	RHOBTB1 GTPase cycle
SRC	SRC proto-oncogene, non-receptor tyrosine kinase	Signaling by ERBB2 Nuclear signaling by ERBB4 Downregulation of ERBB4 signaling PIP3 activates AKT signaling GAB1 signalosome Downstream signal transduction Constitutive Signaling by Aberrant PI3K in Cancer Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events DCC mediated attractive signaling DCC mediated attractive signaling Netrin mediated repulsion signals Regulation of commissural axon pathfinding by SLIT and ROBO RAF activation MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PTK2 signaling InlA-mediated entry of Listeria monocytogenes into host cells Regulation of RUNX1 Expression and Activity RUNX2 regulates osteoblast differentiation Regulation of RUNX3 expression and activity Extra-nuclear estrogen signaling RHOU GTPase cycle Activated NTRK2 signals through FYN Activated NTRK3 signals through PI3K Activated NTRK3 signals through PI3K Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Dasatinib RU84687 RU79256 N6-Benzyl Adenosine-5'-Diphosphate RU85493 RU78262 Phosphonotyrosine Malonic acid RU83876 RU90395 RU79072 RU78783 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine PASBN 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid PAS219 DPI59 RU82197 Phenylphosphate RU78300 RU79073 RU82209 ISO24 RU85053 RU78299 Oxalic Acid RU78191 Citric acid Paratoulene phosphate 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE Purvalanol A XL228 Tirbanibulin Bosutinib 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL PD-168393 [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile PP-121 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide Ponatinib Nintedanib Fostamatinib
SREK1	splicing regulatory glutamic acid and lysine rich protein 1
SRI	sorcin	Stimuli-sensing channels Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Ion homeostasis Ion transport by P-type ATPases	Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
SRRM1	serine and arginine repetitive matrix 1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
SRRM2	serine/arginine repetitive matrix 2	mRNA Splicing - Major Pathway
SRSF1	serine and arginine rich splicing factor 1	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Copper
SRSF11	serine and arginine rich splicing factor 11	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF12	serine and arginine rich splicing factor 12
SRSF2	serine and arginine rich splicing factor 2	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF3	serine and arginine rich splicing factor 3	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF5	serine and arginine rich splicing factor 5	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF6	serine and arginine rich splicing factor 6	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF7	serine and arginine rich splicing factor 7	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRSF8	serine and arginine rich splicing factor 8
SRSF9	serine and arginine rich splicing factor 9	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
SRXN1	sulfiredoxin 1
STON1	stonin 1	Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
SUPT16H	SPT16 homolog, facilitates chromatin remodeling subunit	Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
SYCP2	synaptonemal complex protein 2	Meiotic synapsis
TAF7L	TATA-box binding protein associated factor 7 like	HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome RNA Polymerase II Pre-transcription Events Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Initiation And Promoter Clearance
TCEANC2	transcription elongation factor A N-terminal and central domain containing 2
TCOF1	treacle ribosome biogenesis factor 1
TDP2	tyrosyl-DNA phosphodiesterase 2	Nonhomologous End-Joining (NHEJ)
TLE4	TLE family member 4, transcriptional corepressor	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
TLE5	TLE family member 5, transcriptional modulator	Repression of WNT target genes
TMPO	thymopoietin	RHOA GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
TMPRSS11A	transmembrane serine protease 11A
TMSB10	thymosin beta 10
TNFAIP8L2	TNF alpha induced protein 8 like 2	PI Metabolism
TNFRSF10C	TNF receptor superfamily member 10c	TP53 Regulates Transcription of Death Receptors and Ligands
TNIP2	TNFAIP3 interacting protein 2	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
TNS3	tensin 3	MET interacts with TNS proteins
TOGARAM1	TOG array regulator of axonemal microtubules 1
TOP1	DNA topoisomerase I	SUMOylation of DNA replication proteins	Irinotecan Topotecan Camptothecin Edotecarin Lucanthone Elsamitrucin 7-ethyl-10-hydroxycamptothecin Sodium stibogluconate Cositecan XMT-1001 Rubitecan 2,3-DIMETHOXY-12H-[1,3]DIOXOLO[5,6]INDENO[1,2-C]ISOQUINOLIN-6-IUM 4-(5,11-DIOXO-5H-INDENO[1,2-C]ISOQUINOLIN-6(11H)-YL)BUTANOATE Hexylresorcinol Sacituzumab govitecan Trastuzumab deruxtecan
TPD52	tumor protein D52	Golgi Associated Vesicle Biogenesis
TRA2A	transformer 2 alpha homolog
TRA2B	transformer 2 beta homolog	mRNA Splicing - Major Pathway RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
TRIM4	tripartite motif containing 4	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
TRIM41	tripartite motif containing 41	Antigen processing: Ubiquitination & Proteasome degradation
TRIP12	thyroid hormone receptor interactor 12	Antigen processing: Ubiquitination & Proteasome degradation
TTN	titin	Platelet degranulation Striated Muscle Contraction
TUBA1B	tubulin alpha 1b	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin RHOH GTPase cycle HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	Epothilone D Patupilone CYT997 2-MERCAPTO-N-[1,2,3,10-TETRAMETHOXY-9-OXO-5,6,7,9-TETRAHYDRO-BENZO[A]HEPTALEN-7-YL]ACETAMIDE
TXN	thioredoxin	Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	Phenethyl Isothiocyanate
U2AF2	U2 small nuclear RNA auxiliary factor 2	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
UBD	ubiquitin D	Neddylation
UBE2E2	ubiquitin conjugating enzyme E2 E2	Antigen processing: Ubiquitination & Proteasome degradation
UBR4	ubiquitin protein ligase E3 component n-recognin 4	Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Verpasep caltespen PCL-016
UPF3B	UPF3B regulator of nonsense mediated mRNA decay	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
USP36	ubiquitin specific peptidase 36
USP39	ubiquitin specific peptidase 39	mRNA Splicing - Major Pathway
VAC14	VAC14 component of PIKFYVE complex	Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the Golgi membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the early endosome membrane Synthesis of PIPs at the late endosome membrane Synthesis of PIPs at the late endosome membrane
VAV2	vav guanine nucleotide exchange factor 2	GPVI-mediated activation cascade GPVI-mediated activation cascade NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization EPH-ephrin mediated repulsion of cells G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Signal transduction by L1 VEGFR2 mediated vascular permeability RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
VRK1	VRK serine/threonine kinase 1	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
VSTM2L	V-set and transmembrane domain containing 2 like
WDR24	WD repeat domain 24	Amino acids regulate mTORC1
WDR5	WD repeat domain 5	PKMTs methylate histone lysines HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
WDR70	WD repeat domain 70
XRCC5	X-ray repair cross complementing 5	2-LTR circle formation Cytosolic sensors of pathogen-associated DNA IRF3-mediated induction of type I IFN Nonhomologous End-Joining (NHEJ) Neutrophil degranulation
YBX3	Y-box binding protein 3
YPEL2	yippee like 2
YPEL3	yippee like 3
YRDC	yrdC N6-threonylcarbamoyltransferase domain containing
YTHDC1	YTH domain containing 1
YTHDC2	YTH domain containing 2
ZC3H13	zinc finger CCCH-type containing 13
ZCCHC17	zinc finger CCHC-type containing 17
ZDHHC5	zinc finger DHHC-type palmitoyltransferase 5
ZFC3H1	zinc finger C3H1-type containing
ZFHX4	zinc finger homeobox 4
ZFP91	ZFP91 zinc finger protein, atypical E3 ubiquitin ligase
ZMAT4	zinc finger matrin-type 4
ZMYM4	zinc finger MYM-type containing 4
ZNF140	zinc finger protein 140	Generic Transcription Pathway
ZNF234	zinc finger protein 234	Generic Transcription Pathway
ZNF529	zinc finger protein 529	Generic Transcription Pathway
ZNF592	zinc finger protein 592
ZNF593	zinc finger protein 593
ZNF616	zinc finger protein 616	Generic Transcription Pathway
ZRANB2	zinc finger RANBP2-type containing 2
ZRSR2	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2	mRNA Splicing - Minor Pathway
ZSCAN12	zinc finger and SCAN domain containing 12
ZSCAN9	zinc finger and SCAN domain containing 9

Search Results for: SRPK2