Search Results for: GRIN2A

Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ACOT8 acyl-CoA thioesterase 8
  • Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
  • alpha-linolenic acid (ALA) metabolism
  • Beta-oxidation of pristanoyl-CoA
  • Beta-oxidation of very long chain fatty acids
  • Peroxisomal protein import
  • Peroxisomal protein import
ACTN1 actinin alpha 1
  • Platelet degranulation
  • Syndecan interactions
  • Nephrin family interactions
  • Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
  • RHOD GTPase cycle
  • RHOBTB2 GTPase cycle
  • RHOF GTPase cycle
  • Human calcitonin
  • Copper
AKT1 AKT serine/threonine kinase 1
  • Activation of BAD and translocation to mitochondria
  • PIP3 activates AKT signaling
  • PIP3 activates AKT signaling
  • Downregulation of ERBB2:ERBB3 signaling
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
  • MTOR signalling
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the cytosol
  • AKT phosphorylates targets in the nucleus
  • Negative regulation of the PI3K/AKT network
  • eNOS activation
  • AKT-mediated inactivation of FOXO1A
  • Integrin signaling
  • Deactivation of the beta-catenin transactivating complex
  • CD28 dependent PI3K/Akt signaling
  • CTLA4 inhibitory signaling
  • G beta:gamma signalling through PI3Kgamma
  • Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
  • KSRP (KHSRP) binds and destabilizes mRNA
  • VEGFR2 mediated vascular permeability
  • TP53 Regulates Metabolic Genes
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Interleukin-4 and Interleukin-13 signaling
  • Regulation of TP53 Degradation
  • Regulation of TP53 Activity through Acetylation
  • Regulation of TP53 Activity through Association with Co-factors
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Cyclin E associated events during G1/S transition
  • Cyclin A:Cdk2-associated events at S phase entry
  • PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
  • RAB GEFs exchange GTP for GDP on RABs
  • RUNX2 regulates genes involved in cell migration
  • Regulation of PTEN stability and activity
  • Extra-nuclear estrogen signaling
  • Negative regulation of NOTCH4 signaling
  • FLT3 Signaling
  • Regulation of localization of FOXO transcription factors
  • Estrogen-dependent nuclear events downstream of ESR-membrane signaling
  • ATP
  • Arsenic trioxide
  • Genistein
  • Inositol 1,3,4,5-Tetrakisphosphate
  • Resveratrol
  • Archexin
  • Enzastaurin
  • Perifosine
  • N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
  • 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine
AP1M1 adaptor related protein complex 1 subunit mu 1
  • Nef mediated downregulation of MHC class I complex cell surface expression
  • MHC class II antigen presentation
  • Lysosome Vesicle Biogenesis
  • Golgi Associated Vesicle Biogenesis
  • Neutrophil degranulation
AP2M1 adaptor related protein complex 2 subunit mu 1
  • Nef mediated downregulation of CD28 cell surface expression
  • Nef Mediated CD4 Down-regulation
  • Retrograde neurotrophin signalling
  • Retrograde neurotrophin signalling
  • Nef Mediated CD8 Down-regulation
  • Gap junction degradation
  • Formation of annular gap junctions
  • MHC class II antigen presentation
  • EPH-ephrin mediated repulsion of cells
  • Recycling pathway of L1
  • Recycling pathway of L1
  • WNT5A-dependent internalization of FZD4
  • WNT5A-dependent internalization of FZD2, FZD5 and ROR2
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • VLDLR internalisation and degradation
  • LDL clearance
  • Potential therapeutics for SARS
AP4M1 adaptor related protein complex 4 subunit mu 1
  • Lysosome Vesicle Biogenesis
ARHGAP32 Rho GTPase activating protein 32
  • RHOA GTPase cycle
  • RHOB GTPase cycle
  • RHOC GTPase cycle
  • CDC42 GTPase cycle
  • RAC1 GTPase cycle
  • RAC2 GTPase cycle
  • RHOD GTPase cycle
  • RHOQ GTPase cycle
  • RHOG GTPase cycle
  • RHOJ GTPase cycle
  • RAC3 GTPase cycle
  • RHOF GTPase cycle
CAMK2A calcium/calmodulin dependent protein kinase II alpha
  • CaMK IV-mediated phosphorylation of CREB
  • HSF1-dependent transactivation
  • Trafficking of AMPA receptors
  • Ca2+ pathway
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • Phase 0 - rapid depolarisation
  • Ion homeostasis
  • RAF activation
  • RAF/MAP kinase cascade
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by BRAF and RAF1 fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Interferon gamma signaling
  • Regulation of MECP2 expression and activity
  • Ion transport by P-type ATPases
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • Hexatantalum Dodecabromide
  • 1,4-Dithiothreitol
  • (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}
  • Fostamatinib
CAMK2B calcium/calmodulin dependent protein kinase II beta
  • CaMK IV-mediated phosphorylation of CREB
  • HSF1-dependent transactivation
  • Trafficking of AMPA receptors
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde
  • Ras activation upon Ca2+ influx through NMDA receptor
  • Phase 0 - rapid depolarisation
  • Ion homeostasis
  • RAF activation
  • RAF/MAP kinase cascade
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by BRAF and RAF1 fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • Interferon gamma signaling
  • Regulation of MECP2 expression and activity
  • Ion transport by P-type ATPases
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-6-(methylamino)pyrimidin-2-yl}amino)phenyl]acetonitrile
  • Fostamatinib
CARHSP1 calcium regulated heat stable protein 1
CASK calcium/calmodulin dependent serine protein kinase
  • Dopamine Neurotransmitter Release Cycle
  • Syndecan interactions
  • Nephrin family interactions
  • Neurexins and neuroligins
  • Neurexins and neuroligins
  • Assembly and cell surface presentation of NMDA receptors
  • Sensory processing of sound by inner hair cells of the cochlea
  • Sensory processing of sound by outer hair cells of the cochlea
  • Formic acid
  • Fostamatinib
CDK5 cyclin dependent kinase 5
  • DARPP-32 events
  • CRMPs in Sema3A signaling
  • CRMPs in Sema3A signaling
  • Regulation of TP53 Activity through Phosphorylation
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • NGF-stimulated transcription
  • Activated NTRK2 signals through CDK5
  • Factors involved in megakaryocyte development and platelet production
  • Indirubin-3'-monoxime
  • Olomoucine
  • Hymenialdisine
  • SU9516
  • Alvocidib
  • Alsterpaullone
  • 6-PHENYL[5H]PYRROLO[2,3-B]PYRAZINE
CSNK2A1 casein kinase 2 alpha 1
  • Synthesis of PC
  • WNT mediated activation of DVL
  • Condensation of Prometaphase Chromosomes
  • Signal transduction by L1
  • Regulation of TP53 Activity through Phosphorylation
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
  • ROS sensing by NFE2L2
  • Receptor Mediated Mitophagy
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of PTEN stability and activity
  • ATP
  • (5-hydroxyindolo[1,2-a]quinazolin-7-yl)acetic acid
  • 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One
  • Resveratrol
  • 1,8-Di-Hydroxy-4-Nitro-Anthraquinone
  • Benzamidine
  • 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone
  • Quercetin
  • Phosphoaminophosphonic Acid-Adenylate Ester
  • Tetrabromo-2-Benzotriazole
  • DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE
  • S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
  • N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE
  • Emodin
  • 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE
  • 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one
  • N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE
  • 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
  • 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
  • 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
  • 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE
  • N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE
  • Dichlororibofuranosylbenzimidazole
  • Quinalizarin
  • Ellagic acid
  • Fostamatinib
CSNK2A2 casein kinase 2 alpha 2
  • Synthesis of PC
  • WNT mediated activation of DVL
  • Condensation of Prometaphase Chromosomes
  • Signal transduction by L1
  • Regulation of TP53 Activity through Phosphorylation
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
  • ROS sensing by NFE2L2
  • Receptor Mediated Mitophagy
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of PTEN stability and activity
  • [1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid
  • Fostamatinib
CSNK2B casein kinase 2 beta
  • Synthesis of PC
  • WNT mediated activation of DVL
  • Condensation of Prometaphase Chromosomes
  • Signal transduction by L1
  • Neutrophil degranulation
  • Regulation of TP53 Activity through Phosphorylation
  • Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
  • ROS sensing by NFE2L2
  • Receptor Mediated Mitophagy
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • Regulation of PTEN stability and activity
  • ATP
  • Quercetin
DLG1 discs large MAGUK scaffold protein 1
  • Trafficking of AMPA receptors
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • NrCAM interactions
  • Activation of Ca-permeable Kainate Receptor
  • RAF/MAP kinase cascade
  • Synaptic adhesion-like molecules
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
DLG2 discs large MAGUK scaffold protein 2
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • RAF/MAP kinase cascade
  • Neurexins and neuroligins
  • Neurexins and neuroligins
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
DLG3 discs large MAGUK scaffold protein 3
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • NrCAM interactions
  • Activation of Ca-permeable Kainate Receptor
  • RAF/MAP kinase cascade
  • Neurexins and neuroligins
  • Neurexins and neuroligins
  • Synaptic adhesion-like molecules
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
DLG4 discs large MAGUK scaffold protein 4
  • Signaling by ERBB4
  • Trafficking of AMPA receptors
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • NrCAM interactions
  • Activation of Ca-permeable Kainate Receptor
  • RHO GTPases activate CIT
  • RAF/MAP kinase cascade
  • LGI-ADAM interactions
  • Neurexins and neuroligins
  • Neurexins and neuroligins
  • Synaptic adhesion-like molecules
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Guanidine
  • Guanosine-5'-Monophosphate
DLGAP1 DLG associated protein 1
  • Neurexins and neuroligins
  • Neurexins and neuroligins
EML1 EMAP like 1
FYN FYN proto-oncogene, Src family tyrosine kinase
  • GPVI-mediated activation cascade
  • Signaling by ERBB2
  • PIP3 activates AKT signaling
  • Signaling by SCF-KIT
  • Signaling by SCF-KIT
  • Regulation of KIT signaling
  • Nef and signal transduction
  • Cell surface interactions at the vascular wall
  • FCGR activation
  • PECAM1 interactions
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • DAP12 signaling
  • DAP12 signaling
  • EPH-Ephrin signaling
  • Role of LAT2/NTAL/LAB on calcium mobilization
  • Nephrin family interactions
  • Nephrin family interactions
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • CD28 co-stimulation
  • CD28 dependent PI3K/Akt signaling
  • CD28 dependent Vav1 pathway
  • CTLA4 inhibitory signaling
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • EPHA-mediated growth cone collapse
  • EPHA-mediated growth cone collapse
  • Ephrin signaling
  • Ephrin signaling
  • EPH-ephrin mediated repulsion of cells
  • Sema3A PAK dependent Axon repulsion
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
  • SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
  • CRMPs in Sema3A signaling
  • CRMPs in Sema3A signaling
  • VEGFA-VEGFR2 Pathway
  • Dectin-2 family
  • CD209 (DC-SIGN) signaling
  • RAF/MAP kinase cascade
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • Platelet Adhesion to exposed collagen
  • Reelin signalling pathway
  • Regulation of signaling by CBL
  • Regulation of signaling by CBL
  • FCGR3A-mediated IL10 synthesis
  • FCGR3A-mediated phagocytosis
  • Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants
  • FLT3 signaling through SRC family kinases
  • Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
  • Dasatinib
  • Triglyme
  • Fostamatinib
GRIN1 glutamate ionotropic receptor NMDA type subunit 1
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • RAF/MAP kinase cascade
  • Neurexins and neuroligins
  • Synaptic adhesion-like molecules
  • Assembly and cell surface presentation of NMDA receptors
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Glutamic acid
  • Tramadol
  • Enflurane
  • Atomoxetine
  • Pentobarbital
  • Methadone
  • Secobarbital
  • Meperidine
  • Acamprosate
  • Donepezil
  • Guaifenesin
  • Memantine
  • Memantine
  • Orphenadrine
  • Phenobarbital
  • Aripiprazole
  • Prasterone
  • 5,7-Dichlorokynurenic acid
  • D-Serine
  • Cycloleucine
  • Milnacipran
  • CNS-5161
  • Acetylcysteine
  • Ketobemidone
  • Gavestinel
  • Agmatine
  • Ifenprodil
  • Magnesium acetate tetrahydrate
  • Magnesium carbonate
  • Esketamine
  • Fluciclovine (18F)
GRIN2B glutamate ionotropic receptor NMDA type subunit 2B
  • EPHB-mediated forward signaling
  • EPHB-mediated forward signaling
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Unblocking of NMDA receptors, glutamate binding and activation
  • Ras activation upon Ca2+ influx through NMDA receptor
  • RAF/MAP kinase cascade
  • Neurexins and neuroligins
  • Synaptic adhesion-like molecules
  • MECP2 regulates neuronal receptors and channels
  • Activated NTRK2 signals through FYN
  • Assembly and cell surface presentation of NMDA receptors
  • Assembly and cell surface presentation of NMDA receptors
  • Negative regulation of NMDA receptor-mediated neuronal transmission
  • Long-term potentiation
  • Glutamic acid
  • Tramadol
  • Enflurane
  • Atomoxetine
  • Pentobarbital
  • Methadone
  • Secobarbital
  • Meperidine
  • Haloperidol
  • Acamprosate
  • Donepezil
  • Guaifenesin
  • Felbamate
  • Memantine
  • Phenobarbital
  • Aripiprazole
  • Tenocyclidine
  • Prasterone
  • Taurine
  • Milnacipran
  • EVT-101
  • Lumateperone
  • Acetylcysteine
  • Ketobemidone
  • Gavestinel
  • Ifenprodil
  • Magnesium acetate tetrahydrate
  • Magnesium carbonate
  • Esketamine
  • Esketamine
  • Fluciclovine (18F)
GRIN3A glutamate ionotropic receptor NMDA type subunit 3A
  • Assembly and cell surface presentation of NMDA receptors
  • Assembly and cell surface presentation of NMDA receptors
  • Glutamic acid
  • Tramadol
  • Enflurane
  • Atomoxetine
  • Pentobarbital
  • Methadone
  • Profenamine
  • Secobarbital
  • Dextromethorphan
  • Acamprosate
  • Procaine
  • Donepezil
  • Guaifenesin
  • Ethanol
  • Amantadine
  • Memantine
  • Halothane
  • Orphenadrine
  • Phenobarbital
  • Ketamine
  • Aripiprazole
  • Tenocyclidine
  • Rolicyclidine
  • Prasterone
  • Phencyclidine
  • Milnacipran
  • Neramexane
  • Acetylcysteine
  • Ketobemidone
  • Gavestinel
  • Magnesium acetate tetrahydrate
  • Magnesium carbonate
  • Esketamine
  • Fluciclovine (18F)
GRIN3B glutamate ionotropic receptor NMDA type subunit 3B
  • Assembly and cell surface presentation of NMDA receptors
  • Glycine
  • Tramadol
  • Enflurane
  • Atomoxetine
  • Pentobarbital
  • Methadone
  • Secobarbital
  • Acamprosate
  • Donepezil
  • Guaifenesin
  • Memantine
  • Halothane
  • Orphenadrine
  • Phenobarbital
  • Aripiprazole
  • Tenocyclidine
  • Prasterone
  • Milnacipran
  • Ketobemidone
  • Gavestinel
  • Magnesium acetate tetrahydrate
  • Magnesium carbonate
  • Esketamine
  • Fluciclovine (18F)
ID4 inhibitor of DNA binding 4, HLH protein
  • NGF-stimulated transcription
IL16 interleukin 16
  • Other interleukin signaling
NEDD4 NEDD4 E3 ubiquitin protein ligase
  • ISG15 antiviral mechanism
  • Downregulation of ERBB4 signaling
  • Regulation of PTEN localization
  • Regulation of PTEN stability and activity
  • Antigen processing: Ubiquitination & Proteasome degradation
PATJ PATJ crumbs cell polarity complex component
PCDH8 protocadherin 8
PLA2G10 phospholipase A2 group X
  • Acyl chain remodelling of PC
  • Acyl chain remodelling of PS
  • Acyl chain remodelling of PE
  • Acyl chain remodelling of PI
  • Acyl chain remodelling of PG
  • Synthesis of PA
  • Varespladib methyl
  • Crotalus adamanteus antivenin
  • Agkistrodon piscivorus antivenin
PLCG1 phospholipase C gamma 1
  • ISG15 antiviral mechanism
  • Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
  • PLCG1 events in ERBB2 signaling
  • DAG and IP3 signaling
  • PLC-gamma1 signalling
  • Synthesis of IP3 and IP4 in the cytosol
  • Downstream signal transduction
  • Signaling by ALK
  • Generation of second messenger molecules
  • Role of phospholipids in phagocytosis
  • Role of phospholipids in phagocytosis
  • PECAM1 interactions
  • EGFR interacts with phospholipase C-gamma
  • DAP12 signaling
  • FCERI mediated MAPK activation
  • FCERI mediated Ca+2 mobilization
  • FCERI mediated Ca+2 mobilization
  • Role of second messengers in netrin-1 signaling
  • VEGFR2 mediated cell proliferation
  • VEGFR2 mediated cell proliferation
  • Constitutive Signaling by EGFRvIII
  • Phospholipase C-mediated cascade: FGFR1
  • Phospholipase C-mediated cascade; FGFR2
  • Phospholipase C-mediated cascade; FGFR3
  • Phospholipase C-mediated cascade; FGFR4
  • Signaling by FGFR2 in disease
  • Signaling by FGFR4 in disease
  • Signaling by FGFR1 in disease
  • Signaling by FGFR3 point mutants in cancer
  • RET signaling
  • Activated NTRK2 signals through PLCG1
  • Activated NTRK2 signals through PLCG1
  • Erythropoietin activates Phospholipase C gamma (PLCG)
  • Activated NTRK3 signals through PLCG1
  • Activated NTRK3 signals through PLCG1
  • FCGR3A-mediated IL10 synthesis
  • Signaling by ERBB2 KD Mutants
  • Signaling by ERBB2 ECD mutants
  • Signaling by ERBB2 TMD/JMD mutants
  • Signaling by ALK fusions and activated point mutants
PRKCA protein kinase C alpha
  • Calmodulin induced events
  • Disinhibition of SNARE formation
  • SHC1 events in ERBB2 signaling
  • Signaling by SCF-KIT
  • Regulation of KIT signaling
  • EGFR Transactivation by Gastrin
  • Inactivation, recovery and regulation of the phototransduction cascade
  • Syndecan interactions
  • Acetylcholine regulates insulin secretion
  • Ca2+ pathway
  • Trafficking of GluR2-containing AMPA receptors
  • G alpha (z) signalling events
  • Depolymerisation of the Nuclear Lamina
  • HuR (ELAVL1) binds and stabilizes mRNA
  • WNT5A-dependent internalization of FZD4
  • VEGFR2 mediated cell proliferation
  • RHO GTPases Activate NADPH Oxidases
  • Response to elevated platelet cytosolic Ca2+
  • RET signaling
  • ROBO receptors bind AKAP5
  • ROBO receptors bind AKAP5
  • Phosphatidyl serine
  • Vitamin E
  • Tamoxifen
  • Ingenol mebutate
  • Aprinocarsen
  • Midostaurin
  • Perifosine
  • Ellagic acid
  • Bryostatin 1
  • alpha-Tocopherol succinate
  • D-alpha-Tocopherol acetate
PRM1 protamine 1
PTK2B protein tyrosine kinase 2 beta
  • Signal regulatory protein family interactions
  • VEGFA-VEGFR2 Pathway
  • RHOU GTPase cycle
  • Interleukin-2 signaling
  • Leflunomide
  • Genistein
  • 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
  • Baricitinib
  • Fostamatinib
PTPN4 protein tyrosine phosphatase non-receptor type 4
  • Toll Like Receptor 4 (TLR4) Cascade
  • Interleukin-37 signaling
  • MECP2 regulates neuronal receptors and channels
  • Alendronic acid
RGS3 regulator of G protein signaling 3
  • G alpha (q) signalling events
  • G alpha (i) signalling events
RNF40 ring finger protein 40
  • E3 ubiquitin ligases ubiquitinate target proteins
SPTAN1 spectrin alpha, non-erythrocytic 1
  • Caspase-mediated cleavage of cytoskeletal proteins
  • Nephrin family interactions
  • NCAM signaling for neurite out-growth
  • NCAM signaling for neurite out-growth
  • Interaction between L1 and Ankyrins
  • Interaction between L1 and Ankyrins
  • RAF/MAP kinase cascade
  • Neutrophil degranulation
  • COPI-mediated anterograde transport
  • RHOU GTPase cycle
  • RHOV GTPase cycle
  • Sensory processing of sound by inner hair cells of the cochlea
  • Sensory processing of sound by outer hair cells of the cochlea
SRC SRC proto-oncogene, non-receptor tyrosine kinase
  • Signaling by ERBB2
  • Nuclear signaling by ERBB4
  • Downregulation of ERBB4 signaling
  • PIP3 activates AKT signaling
  • GAB1 signalosome
  • Downstream signal transduction
  • Constitutive Signaling by Aberrant PI3K in Cancer
  • Integrin signaling
  • GRB2:SOS provides linkage to MAPK signaling for Integrins
  • p130Cas linkage to MAPK signaling for integrins
  • G alpha (s) signalling events
  • G alpha (i) signalling events
  • G alpha (i) signalling events
  • DCC mediated attractive signaling
  • DCC mediated attractive signaling
  • Netrin mediated repulsion signals
  • Regulation of commissural axon pathfinding by SLIT and ROBO
  • RAF activation
  • MAP2K and MAPK activation
  • Signaling by moderate kinase activity BRAF mutants
  • Signaling by high-kinase activity BRAF mutants
  • Signaling by BRAF and RAF1 fusions
  • Paradoxical activation of RAF signaling by kinase inactive BRAF
  • PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
  • MET activates PTK2 signaling
  • InlA-mediated entry of Listeria monocytogenes into host cells
  • Regulation of RUNX1 Expression and Activity
  • RUNX2 regulates osteoblast differentiation
  • Regulation of RUNX3 expression and activity
  • Extra-nuclear estrogen signaling
  • RHOU GTPase cycle
  • Activated NTRK2 signals through FYN
  • Activated NTRK3 signals through PI3K
  • Activated NTRK3 signals through PI3K
  • Long-term potentiation
  • Signaling downstream of RAS mutants
  • Signaling by RAF1 mutants
  • Dasatinib
  • RU84687
  • RU79256
  • N6-Benzyl Adenosine-5'-Diphosphate
  • RU85493
  • RU78262
  • Phosphonotyrosine
  • Malonic acid
  • RU83876
  • RU90395
  • RU79072
  • RU78783
  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine
  • PASBN
  • 2-[4-[(Z)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]prop-1-enyl]-2-formylphenyl]acetic acid
  • PAS219
  • DPI59
  • RU82197
  • Phenylphosphate
  • RU78300
  • RU79073
  • RU82209
  • ISO24
  • RU85053
  • RU78299
  • Oxalic Acid
  • RU78191
  • Citric acid
  • Paratoulene phosphate
  • 4-[(4-METHYL-1-PIPERAZINYL)METHYL]-N-[3-[[4-(3-PYRIDINYL)-2-PYRIMIDINYL]AMINO]PHENYL]-BENZAMIDE
  • Purvalanol A
  • XL228
  • Tirbanibulin
  • Bosutinib
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-phenylurea
  • 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL
  • PD-168393
  • [4-({4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl}amino)phenyl]acetonitrile
  • PP-121
  • 1-cyclobutyl-3-(3,4-dimethoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 1-(1-methylethyl)-3-quinolin-6-yl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 2-(4-CARCOXY-5-ISOPROPYLTHIAZOLYL)BENZOPIPERIDINE
  • N-(4-PHENYLAMINO-QUINAZOLIN-6-YL)-ACRYLAMIDE
  • (2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-enamide
  • Ponatinib
  • Nintedanib
  • Fostamatinib