DISC1 - HiPPIP

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide
ABI2	abl interactor 2	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
ACTG1	actin gamma 1	Translocation of SLC2A4 (GLUT4) to the plasma membrane Gap junction degradation Formation of annular gap junctions Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling EPH-ephrin mediated repulsion of cells Adherens junctions interactions Adherens junctions interactions Recycling pathway of L1 Recycling pathway of L1 VEGFA-VEGFR2 Pathway Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Cell-extracellular matrix interactions RHO GTPases activate IQGAPs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate Formins RHO GTPases Activate Formins MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Clathrin-mediated endocytosis RHOBTB2 GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis	Copper Artenimol
ACTN2	actinin alpha 2	Platelet degranulation Nephrin family interactions Striated Muscle Contraction Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
ADO	2-aminoethanethiol dioxygenase	Degradation of cysteine and homocysteine
AGTPBP1	ATP/GTP binding carboxypeptidase 1	Carboxyterminal post-translational modifications of tubulin
AIMP2	aminoacyl tRNA synthetase complex interacting multifunctional protein 2	Selenoamino acid metabolism Cytosolic tRNA aminoacylation
AKAP6	A-kinase anchoring protein 6
ALDH3A2	aldehyde dehydrogenase 3 family member A2	RND2 GTPase cycle RND1 GTPase cycle	NADH
AMOT	angiomotin
AP1M1	adaptor related protein complex 1 subunit mu 1	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Neutrophil degranulation
ARIH2	ariadne RBR E3 ubiquitin protein ligase 2	Antigen processing: Ubiquitination & Proteasome degradation
ARMC7	armadillo repeat containing 7
ATF4	activating transcription factor 4	ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency	Pseudoephedrine
ATF5	activating transcription factor 5	Response of EIF2AK1 (HRI) to heme deficiency	Pseudoephedrine
ATF7IP	activating transcription factor 7 interacting protein	PKMTs methylate histone lysines
BAG2	BAG cochaperone 2	Regulation of HSF1-mediated heat shock response
BFSP2	beaded filament structural protein 2
BICD1	BICD cargo adaptor 1	COPI-independent Golgi-to-ER retrograde traffic
BORCS6	BLOC-1 related complex subunit 6
BRD1	bromodomain containing 1	HATs acetylate histones Regulation of TP53 Activity through Acetylation
C1orf109	chromosome 1 open reading frame 109
C2CD6	C2 calcium dependent domain containing 6
C8orf33	chromosome 8 open reading frame 33
CARD9	caspase recruitment domain family member 9	NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
CCDC102B	coiled-coil domain containing 102B
CCDC13	coiled-coil domain containing 13
CCDC136	coiled-coil domain containing 136
CCDC141	coiled-coil domain containing 141
CCDC197	coiled-coil domain containing 197
CCDC24	coiled-coil domain containing 24
CCDC57	coiled-coil domain containing 57
CCDC88A	coiled-coil domain containing 88A	RND3 GTPase cycle RND1 GTPase cycle
CCDC92	coiled-coil domain containing 92
CCHCR1	coiled-coil alpha-helical rod protein 1
CDC23	cell division cycle 23	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
CDC37	cell division cycle 37, HSP90 cochaperone	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Constitutive Signaling by EGFRvIII Regulation of necroptotic cell death Downregulation of ERBB2 signaling RHOBTB2 GTPase cycle Constitutive Signaling by Overexpressed ERBB2 Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
CDC5L	cell division cycle 5 like	mRNA Splicing - Major Pathway
CDK5RAP3	CDK5 regulatory subunit associated protein 3
CDKL3	cyclin dependent kinase like 3
CEP126	centrosomal protein 126
CEP57	centrosomal protein 57	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
CEP57L1	centrosomal protein 57 like 1
CEP63	centrosomal protein 63	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
CFAP206	cilia and flagella associated protein 206
CIT	citron rho-interacting serine/threonine kinase	RHO GTPases activate CIT RHO GTPases activate CIT RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Fostamatinib
CLU	clusterin	Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
CNST	consortin, connexin sorting protein
COL4A1	collagen type IV alpha 1 chain	Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Scavenging by Class A Receptors NCAM1 interactions Collagen chain trimerization
CTNNA3	catenin alpha 3
CWF19L2	CWF19 like cell cycle control factor 2
DCTN1	dynactin subunit 1	MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Signaling by ALK fusions and activated point mutants
DCTN2	dynactin subunit 2	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
DDX6	DEAD-box helicase 6	mRNA decay by 5' to 3' exoribonuclease	D-tartaric acid
DEGS1	delta 4-desaturase, sphingolipid 1	Sphingolipid de novo biosynthesis Neutrophil degranulation
DMD	dystrophin	Non-integrin membrane-ECM interactions Striated Muscle Contraction	Golodirsen
DNAJC7	DnaJ heat shock protein family (Hsp40) member C7	Regulation of HSF1-mediated heat shock response
DPYSL2	dihydropyrimidinase like 2	CRMPs in Sema3A signaling Recycling pathway of L1	Artenimol
DPYSL3	dihydropyrimidinase like 3	CRMPs in Sema3A signaling
DST	dystonin	Type I hemidesmosome assembly RHOU GTPase cycle RHOV GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
DYNC1H1	dynein cytoplasmic 1 heavy chain 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Neutrophil degranulation COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase AURKA Activation by TPX2 HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
EEF2	eukaryotic translation elongation factor 2	Peptide chain elongation Peptide chain elongation Uptake and function of diphtheria toxin Synthesis of diphthamide-EEF2 Synthesis of diphthamide-EEF2 Neutrophil degranulation Protein methylation	Adenosine-5-Diphosphoribose Diphthamide Guanosine-5'-Diphosphate N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE Esketamine Moxetumomab Pasudotox
EGLN1	egl-9 family hypoxia inducible factor 1	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	Ascorbic acid Iron Roxadustat N-[(4-HYDROXY-8-IODOISOQUINOLIN-3-YL)CARBONYL]GLYCINE FG-2216 Ferrous gluconate Ferrous succinate Ferrous ascorbate Ferrous fumarate Ferrous glycine sulfate
EIF3H	eukaryotic translation initiation factor 3 subunit H	L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
EIF4A3	eukaryotic translation initiation factor 4A3	ISG15 antiviral mechanism Transport of Mature mRNA derived from an Intron-Containing Transcript Deadenylation of mRNA mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
EMSY	EMSY transcriptional repressor, BRCA2 interacting
EXOC1	exocyst complex component 1	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
EXOC4	exocyst complex component 4	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
EXOC7	exocyst complex component 7	Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
EXTL1	exostosin like glycosyltransferase 1	XBP1(S) activates chaperone genes
FBXO34	F-box protein 34
FBXO41	F-box protein 41	Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Phenethyl Isothiocyanate
FBXW7	F-box and WD repeat domain containing 7	Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation
FEZ1	fasciculation and elongation protein zeta 1
FLACC1	flagellum associated containing coiled-coil domains 1
FRYL	FRY like transcription coactivator
GABARAPL1	GABA type A receptor associated protein like 1	Macroautophagy
GAS2L2	growth arrest specific 2 like 2
GAS8	growth arrest specific 8	Activation of SMO
GCC1	GRIP and coiled-coil domain containing 1	Retrograde transport at the Trans-Golgi-Network
GEM	GTP binding protein overexpressed in skeletal muscle
GNB1	G protein subunit beta 1	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Activation of the phototransduction cascade Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNG13	G protein subunit gamma 13	Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Olfactory Signaling Pathway Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
GNPTAB	N-acetylglucosamine-1-phosphate transferase subunits alpha and beta
GPANK1	G-patch domain and ankyrin repeats 1
GPRASP2	G protein-coupled receptor associated sorting protein 2
GRIPAP1	GRIP1 associated protein 1
GSK3B	glycogen synthase kinase 3 beta	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade AKT phosphorylates targets in the cytosol Regulation of HSF1-mediated heat shock response CRMPs in Sema3A signaling Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane B-WICH complex positively regulates rRNA expression Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Constitutive Signaling by AKT1 E17K in Cancer Ubiquitin-dependent degradation of Cyclin D Regulation of RUNX2 expression and activity Maturation of nucleoprotein Maturation of nucleoprotein	Lithium cation 3-[3-(2,3-Dihydroxy-Propylamino)-Phenyl]-4-(5-Fluoro-1-Methyl-1h-Indol-3-Yl)-Pyrrole-2,5-Dione SB-409513 AR-AO-14418 Staurosporine Indirubin-3'-monoxime 6-bromoindirubin-3'-oxime Alsterpaullone Phosphoaminophosphonic Acid-Adenylate Ester 2-(1,3-benzodioxol-5-yl)-5-[(3-fluoro-4-methoxybenzyl)sulfanyl]-1,3,4-oxadiazole 5-[1-(4-methoxyphenyl)-1H-benzimidazol-6-yl]-1,3,4-oxadiazole-2(3H)-thione (7S)-2-(2-aminopyrimidin-4-yl)-7-(2-fluoroethyl)-1,5,6,7-tetrahydro-4H-pyrrolo[3,2-c]pyridin-4-one N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine 5-(5-chloro-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine 3-({[(3S)-3,4-dihydroxybutyl]oxy}amino)-1H,2'H-2,3'-biindol-2'-one N-[(1S)-2-amino-1-phenylethyl]-5-(1H-pyrrolo[2,3-b]pyridin-4-yl)thiophene-2-carboxamide 4-(4-CHLOROPHENYL)-4-[4-(1H-PYRAZOL-4-YL)PHENYL]PIPERIDINE ISOQUINOLINE-5-SULFONIC ACID (2-(2-(4-CHLOROBENZYLOXY)ETHYLAMINO)ETHYL)AMIDE (2S)-1-(1H-INDOL-3-YL)-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE Fostamatinib Tideglusib Lithium citrate Lithium succinate Lithium carbonate
HERC2P2	HERC2 pseudogene 2
HNRNPC	heterogeneous nuclear ribonucleoprotein C	SUMOylation of RNA binding proteins mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA RHOBTB2 GTPase cycle RHOBTB1 GTPase cycle
IFT20	intraflagellar transport 20	Intraflagellar transport Intraflagellar transport
IFT74	intraflagellar transport 74	Intraflagellar transport Intraflagellar transport
IMMT	inner membrane mitochondrial protein	Cristae formation
ITSN1	intersectin 1	NRAGE signals death through JNK EPHB-mediated forward signaling EPHB-mediated forward signaling G alpha (12/13) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis CDC42 GTPase cycle RHOQ GTPase cycle RHOG GTPase cycle
KALRN	kalirin RhoGEF kinase	NRAGE signals death through JNK EPHB-mediated forward signaling G alpha (q) signalling events G alpha (12/13) signalling events MAPK6/MAPK4 signaling RHOA GTPase cycle RAC1 GTPase cycle RHOG GTPase cycle
KANSL1	KAT8 regulatory NSL complex subunit 1	HATs acetylate histones
KCNQ5	potassium voltage-gated channel subfamily Q member 5	Voltage gated Potassium channels	Enflurane Gabapentin Promethazine Miconazole Ezogabine ICA-105665
KIF3A	kinesin family member 3A	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Hedgehog 'off' state Intraflagellar transport Activation of SMO Activation of SMO COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
KIF3C	kinesin family member 3C	MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
KIF9	kinesin family member 9	COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
KIFAP3	kinesin associated protein 3	Translocation of SLC2A4 (GLUT4) to the plasma membrane MHC class II antigen presentation Intraflagellar transport COPI-dependent Golgi-to-ER retrograde traffic Kinesins Kinesins
KIFC3	kinesin family member C3
LENG1	leukocyte receptor cluster member 1
MACF1	microtubule actin crosslinking factor 1
MAP1A	microtubule associated protein 1A		Estramustine
MEMO1	mediator of cell motility 1	ERBB2 Regulates Cell Motility
MLLT10	MLLT10 histone lysine methyltransferase DOT1L cofactor
MNS1	meiosis specific nuclear structural 1
MORF4L2	mortality factor 4 like 2	HATs acetylate histones
MPPED1	metallophosphoesterase domain containing 1
MVP	major vault protein	Neutrophil degranulation
MYH7	myosin heavy chain 7		4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID
MYT1L	myelin transcription factor 1 like
NCK2	NCK adaptor protein 2	Downstream signal transduction Nephrin family interactions Ephrin signaling Activation of RAC1 VEGFA-VEGFR2 Pathway Regulation of cortical dendrite branching RHOU GTPase cycle RHOV GTPase cycle
NDE1	nudE neurodevelopment protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
NDEL1	nudE neurodevelopment protein 1 like 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
NECAB1	N-terminal EF-hand calcium binding protein 1
NEFM	neurofilament medium chain
NME7	NME/NM23 family member 7	Recruitment of mitotic centrosome proteins and complexes Recruitment of NuMA to mitotic centrosomes
NSRP1	nuclear speckle splicing regulatory protein 1
NUP160	nucleoporin 160	ISG15 antiviral mechanism Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs snRNP Assembly Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) RHO GTPases Activate Formins tRNA processing in the nucleus Mitotic Prometaphase HCMV Early Events HCMV Late Events Postmitotic nuclear pore complex (NPC) reformation Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
OLFM1	olfactomedin 1
PCNT	pericentrin	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 Chaperone Mediated Autophagy Late endosomal microautophagy Aggrephagy Aggrephagy
PCNX4	pecanex 4
PDE4B	phosphodiesterase 4B	DARPP-32 events	Adenosine phosphate Caffeine Caffeine Theophylline Dyphylline Enprofylline Iloprost Papaverine Theobromine Amrinone Daxalipram Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Filaminast 8-Bromo-Adenosine-5'-Monophosphate (S)-Rolipram 1-(2-Chlorophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Cilomilast (R)-Rolipram S,S-(2-Hydroxyethyl)Thiocysteine Crisaborole Ibudilast 1-ethyl-N-(phenylmethyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridine-5-carboxamide 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
PGK1	phosphoglycerate kinase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate 3-phospho-D-glyceric acid Copper Artenimol
PHF1	PHD finger protein 1	PRC2 methylates histones and DNA
PIBF1	progesterone immunomodulatory binding factor 1
PIK3R3	phosphoinositide-3-kinase regulatory subunit 3	GPVI-mediated activation cascade PIP3 activates AKT signaling Interleukin-7 signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane Constitutive Signaling by Aberrant PI3K in Cancer Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Extra-nuclear estrogen signaling RAC1 GTPase cycle RAC2 GTPase cycle Interleukin receptor SHC signaling Regulation of signaling by CBL Regulation of signaling by CBL Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants	Isoprenaline SF1126
PKN1	protein kinase N1	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle RAC1 GTPase cycle	Fostamatinib
POLR3C	RNA polymerase III subunit C	Cytosolic sensors of pathogen-associated DNA RNA Polymerase III Chain Elongation RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
PPFIA3	PTPRF interacting protein alpha 3	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Receptor-type tyrosine-protein phosphatases
PPM1E	protein phosphatase, Mg2+/Mn2+ dependent 1E	Negative regulation of NMDA receptor-mediated neuronal transmission
PPP4R1	protein phosphatase 4 regulatory subunit 1
PPP5C	protein phosphatase 5 catalytic subunit	Negative regulation of MAPK pathway Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks ESR-mediated signaling	ATP
PSPC1	paraspeckle component 1
QARS1	glutaminyl-tRNA synthetase 1	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
RABGAP1	RAB GTPase activating protein 1	TBC/RABGAPs
RAD21	RAD21 cohesin complex component	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
RANBP9	RAN binding protein 9	L1CAM interactions RAF/MAP kinase cascade MET activates RAS signaling
RASSF7	Ras association domain family member 7
RBM41	RNA binding motif protein 41
RBSN	rabenosyn, RAB effector	Toll Like Receptor 9 (TLR9) Cascade Factors involved in megakaryocyte development and platelet production
RECK	reversion inducing cysteine rich protein with kazal motifs	Post-translational modification: synthesis of GPI-anchored proteins
RNF40	ring finger protein 40	E3 ubiquitin ligases ubiquitinate target proteins
ROGDI	rogdi atypical leucine zipper
RTRAF	RNA transcription, translation and transport factor	tRNA processing in the nucleus
SH3BP5	SH3 domain binding protein 5
SMARCD1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known	Phenethyl Isothiocyanate
SMC2	structural maintenance of chromosomes 2	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
SMC3	structural maintenance of chromosomes 3	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
SMC5	structural maintenance of chromosomes 5	SUMOylation of DNA damage response and repair proteins
SMYD1	SET and MYND domain containing 1
SNX6	sorting nexin 6
SPARCL1	SPARC like 1	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
SPATC1L	spermatogenesis and centriole associated 1 like
SPTBN4	spectrin beta, non-erythrocytic 4	NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport
SRGAP2	SLIT-ROBO Rho GTPase activating protein 2	Inactivation of CDC42 and RAC1 RHO GTPases Activate Formins CDC42 GTPase cycle RAC1 GTPase cycle RHOQ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOF GTPase cycle
SRGAP3	SLIT-ROBO Rho GTPase activating protein 3	Inactivation of CDC42 and RAC1 CDC42 GTPase cycle RAC1 GTPase cycle
STX11	syntaxin 11
STX18	syntaxin 18	COPI-dependent Golgi-to-ER retrograde traffic
SUFU	SUFU negative regulator of hedgehog signaling	Degradation of GLI1 by the proteasome Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'off' state Hedgehog 'on' state
SYBU	syntabulin
SYNE1	spectrin repeat containing nuclear envelope protein 1	Meiotic synapsis
TCAF1	TRPM8 channel associated factor 1
TCEANC	transcription elongation factor A N-terminal and central domain containing
TFIP11	tuftelin interacting protein 11	mRNA Splicing - Major Pathway
TIAM2	TIAM Rac1 associated GEF 2	NRAGE signals death through JNK PPARA activates gene expression G alpha (12/13) signalling events RAC1 GTPase cycle
TNKS	tankyrase	TCF dependent signaling in response to WNT Degradation of AXIN XAV939 stabilizes AXIN Ub-specific processing proteases Regulation of PTEN stability and activity
TP53BP2	tumor protein p53 binding protein 2	Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
TRAF3IP1	TRAF3 interacting protein 1	Intraflagellar transport Intraflagellar transport
TRAF4	TNF receptor associated factor 4
TRIM29	tripartite motif containing 29	Interferon gamma signaling
TRIM68	tripartite motif containing 68	Interferon gamma signaling
TRIO	trio Rho guanine nucleotide exchange factor	NRAGE signals death through JNK G alpha (q) signalling events G alpha (12/13) signalling events DCC mediated attractive signaling DCC mediated attractive signaling RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
TSGA10	testis specific 10
TSPOAP1	TSPO associated protein 1	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Pregnenolone biosynthesis Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle
TSR2	TSR2 ribosome maturation factor
TTC23	tetratricopeptide repeat domain 23
TUBB	tubulin beta class I	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS	Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
TUBB2A	tubulin beta 2A class IIa	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins	CYT997 Phenethyl Isothiocyanate
UBASH3A	ubiquitin associated and SH3 domain containing A
UBASH3B	ubiquitin associated and SH3 domain containing B
USP2	ubiquitin specific peptidase 2	TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway Ub-specific processing proteases Regulation of TP53 Degradation
UTRN	utrophin	EGR2 and SOX10-mediated initiation of Schwann cell myelination	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
XPNPEP1	X-prolyl aminopeptidase 1
YWHAE	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Signaling by Hippo NADE modulates death signalling Regulation of PLK1 Activity at G2/M Transition Regulation of HSF1-mediated heat shock response HSF1 activation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RAB GEFs exchange GTP for GDP on RABs	Fusicoccin Phenethyl Isothiocyanate
YWHAG	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex AURKA Activation by TPX2 Regulation of localization of FOXO transcription factors
YWHAQ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors	Phenethyl Isothiocyanate
YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors	Phenethyl Isothiocyanate
ZNF124	zinc finger protein 124	Generic Transcription Pathway
ZNF197	zinc finger protein 197	Generic Transcription Pathway
ZNF365	zinc finger protein 365
ZNF76	zinc finger protein 76

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