| BCL2 |
BCL2 apoptosis regulator |
- Activation of BAD and translocation to mitochondria
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- Estrogen-dependent gene expression
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
- Paclitaxel docosahexaenoic acid
- Apoptone
- Glycine betaine
- Eribulin
- Dexibuprofen
- Isosorbide
- Venetoclax
- Obatoclax
- Navitoclax
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| CAMK2A |
calcium/calmodulin dependent protein kinase II alpha |
- CaMK IV-mediated phosphorylation of CREB
- HSF1-dependent transactivation
- Trafficking of AMPA receptors
- Ca2+ pathway
- Unblocking of NMDA receptors, glutamate binding and activation
- Unblocking of NMDA receptors, glutamate binding and activation
- Ras activation upon Ca2+ influx through NMDA receptor
- Phase 0 - rapid depolarisation
- Ion homeostasis
- RAF activation
- RAF/MAP kinase cascade
- Signaling by moderate kinase activity BRAF mutants
- Signaling by BRAF and RAF1 fusions
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Interferon gamma signaling
- Regulation of MECP2 expression and activity
- Ion transport by P-type ATPases
- Assembly and cell surface presentation of NMDA receptors
- Negative regulation of NMDA receptor-mediated neuronal transmission
- Long-term potentiation
- Signaling downstream of RAS mutants
- Signaling by RAF1 mutants
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- Hexatantalum Dodecabromide
- 1,4-Dithiothreitol
- (2Z,3E)-2,3'-biindole-2',3(1H,1'H)-dione 3-{O-[(3R)-3,4-dihydroxybutyl]oxime}
- Fostamatinib
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| CCR4 |
C-C motif chemokine receptor 4 |
- Chemokine receptors bind chemokines
- G alpha (i) signalling events
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| CHRM5 |
cholinergic receptor muscarinic 5 |
- Muscarinic acetylcholine receptors
- G alpha (q) signalling events
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- Ziprasidone
- Amitriptyline
- Metixene
- Terfenadine
- Clozapine
- Doxylamine
- Trihexyphenidyl
- Loxapine
- Meperidine
- Imipramine
- Darifenacin
- Nortriptyline
- Amoxapine
- Cinnarizine
- Atropine
- Nicardipine
- Paroxetine
- Homatropine methylbromide
- Trimipramine
- Scopolamine
- Benzquinamide
- Propiomazine
- Brompheniramine
- Maprotiline
- Methantheline
- Tolterodine
- Promethazine
- Doxepin
- Desipramine
- Ketamine
- Quetiapine
- Aripiprazole
- Chlorprothixene
- Methotrimeprazine
- Tiotropium
- Solifenacin
- ALKS 27
- Fesoterodine
- Aclidinium
- Umeclidinium
- Dosulepin
- Etoperidone
- Homatropine
- Thonzylamine
- Revefenacin
- Propiverine
- Rociverine
- Aripiprazole lauroxil
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| F2RL1 |
F2R like trypsin receptor 1 |
- Peptide ligand-binding receptors
- G alpha (q) signalling events
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| FGL2 |
fibrinogen like 2 |
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| HGS |
hepatocyte growth factor-regulated tyrosine kinase substrate |
- EGFR downregulation
- Lysosome Vesicle Biogenesis
- Ub-specific processing proteases
- Negative regulation of MET activity
- Cargo recognition for clathrin-mediated endocytosis
- Clathrin-mediated endocytosis
- InlB-mediated entry of Listeria monocytogenes into host cell
- RHOU GTPase cycle
- Endosomal Sorting Complex Required For Transport (ESCRT)
- Inhibition of membrane repair
- Prevention of phagosomal-lysosomal fusion
- RHOBTB3 ATPase cycle
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| IRS1 |
insulin receptor substrate 1 |
- PI3K Cascade
- IRS-mediated signalling
- SOS-mediated signalling
- SOS-mediated signalling
- PIP3 activates AKT signaling
- Interleukin-7 signaling
- PI3K/AKT activation
- PI3K/AKT activation
- Signaling by ALK
- Constitutive Signaling by Aberrant PI3K in Cancer
- IRS-related events triggered by IGF1R
- Signaling by Leptin
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- IRS activation
- Signal attenuation
- Activated NTRK3 signals through PI3K
- Signaling by ALK fusions and activated point mutants
- Growth hormone receptor signaling
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- [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
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| IRS2 |
insulin receptor substrate 2 |
- PI3K Cascade
- IRS-mediated signalling
- SOS-mediated signalling
- SOS-mediated signalling
- PIP3 activates AKT signaling
- Interleukin-7 signaling
- PI3K/AKT activation
- PI3K/AKT activation
- Constitutive Signaling by Aberrant PI3K in Cancer
- IRS-related events triggered by IGF1R
- Signaling by Leptin
- RAF/MAP kinase cascade
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- IRS activation
- Signal attenuation
- RET signaling
- Signaling by Erythropoietin
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
- Erythropoietin activates Phospholipase C gamma (PLCG)
- Erythropoietin activates STAT5
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Growth hormone receptor signaling
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| MDM2 |
MDM2 proto-oncogene |
- AKT phosphorylates targets in the cytosol
- Oxidative Stress Induced Senescence
- Oncogene Induced Senescence
- SUMOylation of transcription factors
- SUMOylation of ubiquitinylation proteins
- Trafficking of AMPA receptors
- Constitutive Signaling by AKT1 E17K in Cancer
- Ub-specific processing proteases
- Regulation of TP53 Activity through Phosphorylation
- Regulation of TP53 Degradation
- Regulation of TP53 Activity through Methylation
- Stabilization of p53
- Regulation of RUNX3 expression and activity
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- Zinc
- Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone
- Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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| PLN |
phospholamban |
- Ion homeostasis
- Ion transport by P-type ATPases
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| S100A1 |
S100 calcium binding protein A1 |
- ER-Phagosome pathway
- MyD88:MAL(TIRAP) cascade initiated on plasma membrane
- MyD88 deficiency (TLR2/4)
- IRAK4 deficiency (TLR2/4)
- Regulation of TLR by endogenous ligand
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| SMCO4 |
single-pass membrane protein with coiled-coil domains 4 |
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| SPP1 |
secreted phosphoprotein 1 |
- Degradation of the extracellular matrix
- Signaling by PDGF
- Integrin cell surface interactions
- Integrin cell surface interactions
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- RUNX3 Regulates Immune Response and Cell Migration
- Post-translational protein phosphorylation
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| TRIM14 |
tripartite motif containing 14 |
- Interferon gamma signaling
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| UNG |
uracil DNA glycosylase |
|
- 4-[(1E,7E)-8-(2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDIN-4-YL)-3,6-DIOXA-2,7-DIAZAOCTA-1,7-DIEN-1-YL]BENZOIC ACID
- 1-(2-DEOXY-5-O-PHOSPHONO-BETA-D-ERYTHRO-PENTOFURANOSYL)-4-METHYL-1H-INDOLE
- 3-[(1E,7E)-8-(2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)-3,6-dioxa-2,7-diazaocta-1,7-dien-1-yl]benzoic acid
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