EIF2AK3

Description		eukaryotic translation initiation factor 2 alpha kinase 3
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Eukaryotic Translation Initiation Factor 2alpha Kinase Activity Protein Binding ATP Binding Enzyme Binding Protein Phosphatase Binding Identical Protein Binding Hsp90 Protein Binding Protein Serine Kinase Activity
	Biological Process	Skeletal System Development Ossification Angiogenesis Chondrocyte Development Protein Phosphorylation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process ER Overload Response Endoplasmic Reticulum Organization Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Regulation Of Translational Initiation By EIF2 Alpha Phosphorylation Negative Regulation Of Translation Peptidyl-serine Phosphorylation Calcium-mediated Signaling Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Endocrine Pancreas Development Negative Regulation Of Myelination Negative Regulation Of Translation In Response To Stress Negative Regulation Of Translational Initiation In Response To Stress Cellular Response To Amino Acid Starvation Response To Endoplasmic Reticulum Stress EiF2alpha Phosphorylation In Response To Endoplasmic Reticulum Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Positive Regulation Of Transcription By RNA Polymerase I Protein Autophosphorylation Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cellular Response To Cold Positive Regulation Of Protein Localization To Nucleus Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Manganese-induced Endoplasmic Reticulum Stress
Pathways		PERK regulates gene expression ALK mutants bind TKIs Signaling by ALK fusions and activated point mutants
Drugs
Diseases
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Chronotype ( 30696823) Height ( 20881960 25282103 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Progressive supranuclear palsy ( 21685912)
Interacting Genes		6 interacting genes: DNAJC3 EIF2S1 HSP90AA1 HSPA5 IKBKB NFE2L2
Entrez ID		9451
HPRD ID		04942
Ensembl ID		ENSG00000172071
Uniprot IDs		B3KY45 Q68DI6 Q9NZJ5
PDB IDs		4G31 4G34 4M7I 4X7H 4X7J 4X7K 4X7L 4X7N 4X7O 4YZS 5SV7
Enriched GO Terms of Interacting Partners?
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