NLRP12

Description		NLR family pyrin domain containing 12
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GO Annotations	Cellular Component	Nucleus Cytoplasm
	Molecular Function	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
	Biological Process	Negative Regulation Of Cytokine Production Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Signal Transduction Negative Regulation Of Protein Autophosphorylation Negative Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-1 Beta Production Dendritic Cell Migration Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MHC Class I Biosynthetic Process Negative Regulation Of Toll Signaling Pathway Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Negative Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of NIK/NF-kappaB Signaling
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Fasting glucose ( 33381925) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Testicular germ cell tumor ( 28604728)
Interacting Genes		3 interacting genes: FAF1 IRAK1 PYCARD
Entrez ID		91662
HPRD ID		14803
Ensembl ID		ENSG00000142405
Uniprot IDs		P59046
PDB IDs		2L6A 4XHS 5H7N
Enriched GO Terms of Interacting Partners?
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