DOT1L

Description		DOT1 like histone lysine methyltransferase
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Protein Binding Histone-lysine N-methyltransferase Activity Histone Methyltransferase Activity (H3-K79 Specific) Histone Methyltransferase Activity
	Biological Process	DNA Damage Checkpoint Signaling DNA Repair Positive Regulation Of Cell Population Proliferation Gene Expression Telomere Organization Histone H3-K79 Methylation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Heel bone mineral density ( 30598549 28869591) Height ( 28552196 20881960 25282103 23563607 18391950) Hematocrit ( 29403010) Hemoglobin ( 29403010) Hemoglobin levels ( 32327693) Hip circumference adjusted for BMI ( 34021172 25673412) Hip minimal joint space width ( 27701424) Myocardial infarction ( 24916648) Osteoarthritis ( 22566624) Platelet count ( 32888494) Plateletcrit ( 32888494) Pulse pressure ( 26390057 27841878 29403010 27618448 30487518 30578418) Red blood cell count ( 29403010) Systemic lupus erythematosus ( 33493351) Systolic blood pressure ( 27618448 30487518) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: H3-4 MLLT10 MYCN STAT1
Entrez ID		84444
HPRD ID		10455
Ensembl ID		ENSG00000104885
Uniprot IDs		Q8TEK3
PDB IDs		1NW3 2MV7 3QOW 3QOX 3SR4 3SX0 3UWP 4EK9 4EKG 4EKI 4EQZ 4ER0 4ER3 4ER5 4ER6 4ER7 4HRA 4WVL 5DRT 5DRY 5DSX 5DT2 5DTM 5DTQ 5DTR 5JUW 5MVS 5MW3 5MW4 6IN3 6J99 6JM9 6JMA 6JN2 6NJ9 6NN6 6NOG 6NQA 6O96 6TE6 6TEL 6TEN
Enriched GO Terms of Interacting Partners?
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