TOP2B

Description		DNA topoisomerase II beta
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Nucleolus Cytosol Ribonucleoprotein Complex
	Molecular Function	DNA Binding Chromatin Binding DNA Topoisomerase Type II (double Strand Cut, ATP-hydrolyzing) Activity Protein Kinase C Binding ATP Binding Protein C-terminus Binding Enzyme Binding Histone Deacetylase Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Resolution Of Meiotic Recombination Intermediates Sister Chromatid Segregation Neuron Migration DNA Topological Change Axonogenesis Forebrain Development Positive Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Pathways		SUMOylation of DNA replication proteins
Drugs		Dexrazoxane Daunorubicin Etoposide Dactinomycin Phosphoaminophosphonic Acid-Adenylate Ester Amonafide Technetium Tc-99m ciprofloxacin ZEN-012 Becatecarin Declopramide 3'-THIO-THYMIDINE-5'-PHOSPHATE
Diseases
GWAS		Chronic obstructive pulmonary disease ( 30804561)
Interacting Genes		19 interacting genes: CD3E CSNK2B ERG HDAC1 HDAC2 LAMTOR5 MAPK3 PIAS4 RANBP2 RARA RNF4 SUMO1 SUMO2 TOP2A TOPBP1 TP53 UBE2I XPO1 XRCC5
Entrez ID		7155
HPRD ID		00537
Ensembl ID		ENSG00000077097
Uniprot IDs		Q02880 Q59H80
PDB IDs		3QX3 4G0U 4G0V 4G0W 4J3N 5GWI 5GWJ 5ZAD 5ZEN 5ZQF 5ZRF
Enriched GO Terms of Interacting Partners?
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