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C1QA

Description complement C1q A chain
Image
GO Annotations Cellular Component
  • Extracellular Region
  • Collagen Trimer
  • Complement Component C1 Complex
  • Synapse
  • Collagen-containing Extracellular Matrix
  • Postsynapse
Molecular Function
  • Amyloid-beta Binding
  • Protein Binding
Biological Process
  • Microglial Cell Activation
  • Complement Activation
  • Complement Activation, Classical Pathway
  • Cell-cell Signaling
  • Aging
  • Response To Iron Ion
  • Neuron Remodeling
  • Innate Immune Response
  • Astrocyte Activation
  • Synapse Organization
  • Synapse Pruning
  • Complement-mediated Synapse Pruning
  • Vertebrate Eye-specific Patterning
  • Positive Regulation Of Neuron Death
Pathways
  • Initial triggering of complement
  • Classical antibody-mediated complement activation
  • Regulation of Complement cascade
Drugs
  • Cetuximab
  • Etanercept
  • Palivizumab
  • Daclizumab
  • Bevacizumab
Diseases
GWAS
  • Inflammatory biomarkers (multivariate analysis) ( 33110245)
Interacting Genes 29 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SGTB SLC25A47 UBQLN1 UBQLN2
Entrez ID 712
HPRD ID 00393
Ensembl ID ENSG00000173372
Uniprot IDs A0A024RAG6 P02745
PDB IDs 1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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