BUB1B

Description		BUB1 mitotic checkpoint serine/threonine kinase B
Image
GO Annotations	Cellular Component	Kinetochore Outer Kinetochore Anaphase-promoting Complex Cytoplasm Microtubule Organizing Center Spindle Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Apoptotic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Checkpoint Signaling Mitotic Spindle Assembly Checkpoint Signaling Cell Division Meiotic Sister Chromatid Cohesion, Centromeric Protein Localization To Chromosome, Centromeric Region
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274)
Interacting Genes		25 interacting genes: ANAPC7 AP1B1 AP2B1 AP3B1 AP4B1 APC BRCA2 BUB3 CCNA2 CDC16 CDC20 CDC27 CENPE COMMD4 DNMBP FBXO7 HDAC1 KNL1 MAP3K4 PELI1 PLK1 RIPK3 SNCG TP73 TRIP13
Entrez ID		701
HPRD ID		04176
Ensembl ID		ENSG00000156970
Uniprot IDs		O60566
PDB IDs		2WVI 3SI5 4GGD 5JJA 5K6S 5KHU 5LCW 5SWF 6TLJ
Enriched GO Terms of Interacting Partners?
Tagcloud ?