HNF1A

Description		HNF1 homeobox A
Image
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		Regulation of gene expression in beta cells
Drugs		D-norleucine
Diseases
GWAS		Acute insulin response ( 28490609) Age at first birth ( 34211149) Apolipoprotein B levels ( 32203549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 24763700 29403010 33339817 30388399 21300955 31622379) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Ceramide levels (C22:0) ( 32489964) Chloride levels ( 29403010) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 32469254 29212778 30104761 28714974 33020668) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 29403010 33339817 22010049) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) High-sensitivity C-reactive protein levels in HIV infection ( 33095540) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) Low density lipoprotein cholesterol levels ( 32154731 33339817) Myocardial infarction ( 33532862) N-glycan levels ( 21908519 21203500) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 33547301 31666285 33339817) Serum alpha1-antitrypsin levels ( 26174136) Serum C-reactive protein concentration ( 32928877) Serum C-reactive protein concentration in high fat diet ( 32928877) Serum C-reactive protein concentration in low fat diet ( 32928877) Serum C-reactive protein concentration in non-obese individuals ( 32928877) Serum C-reactive protein concentration in obesity ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist circumference) ( 32928877) Serum C-reactive protein concentration in visceral obesity (waist-hip ratio) ( 32928877) Serum metabolite levels (CMS) ( 31636271) Stroke ( 32693751) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 21573907 22885922 24509480 30297969 29632382 26818947 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528 23263486) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		25 interacting genes: ALB APAF1 BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5
Entrez ID		6927
HPRD ID		00800
Ensembl ID		ENSG00000135100
Uniprot IDs		E0YMI7 P20823
PDB IDs		1IC8 2GYP
Enriched GO Terms of Interacting Partners?
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