SLC12A3

Description		solute carrier family 12 member 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity
	Biological Process	Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)
Drugs		Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases
GWAS		HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) HDL levels x fish oil supplementation interaction (1df) ( 33760818) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Phoneme awareness ( 30741946)
Interacting Genes		2 interacting genes: PDIA3 WNK4
Entrez ID		6559
HPRD ID		02984
Ensembl ID		ENSG00000070915
Uniprot IDs		J3QSS1 P55017
PDB IDs
Enriched GO Terms of Interacting Partners?
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