SKI

Description		SKI proto-oncogene
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Centrosome Nuclear Body PML Body Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Zinc Ion Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding SMAD Binding Histone Deacetylase Inhibitor Activity DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Tube Closure Lens Morphogenesis In Camera-type Eye Transcription, DNA-templated Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Population Proliferation Anterior/posterior Axis Specification Negative Regulation Of Schwann Cell Proliferation Myotube Differentiation Olfactory Bulb Development Myelination In Peripheral Nervous System Positive Regulation Of Wnt Signaling Pathway Embryonic Limb Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Histone Deacetylation Negative Regulation Of Activin Receptor Signaling Pathway Somatic Stem Cell Population Maintenance Camera-type Eye Development Positive Regulation Of DNA Binding Nose Morphogenesis Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Camera-type Eye Morphogenesis Skeletal Muscle Fiber Development Cell Motility Roof Of Mouth Development Retina Development In Camera-type Eye Face Morphogenesis Bone Morphogenesis SMAD Protein Signal Transduction
Pathways		Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Body mass index ( 26426971) Coronary artery disease ( 29212778) Liver enzyme levels (alanine transaminase) ( 33972514) Myocardial infarction ( 33532862) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494) PR interval ( 30046033 32439900) Systolic blood pressure ( 30224653) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: AKT1 GLI2 GLI3 HIPK2 JUN MECP2 MYB NCOR1 NFIX PML SIN3A SKIL SMAD1 SMAD2 SMAD3 SMAD4 SNW1 SPI1 TGFBR1 TRIM28
Entrez ID		6497
HPRD ID		01271
Ensembl ID		ENSG00000157933
Uniprot IDs		P12755
PDB IDs		1MR1 1SBX 5XOD
Enriched GO Terms of Interacting Partners?
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