CDKAL1

Description		CDK5 regulatory subunit associated protein 1 like 1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding N6-threonylcarbomyladenosine Methylthiotransferase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding TRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase
	Biological Process	Biological_process TRNA Methylthiolation Maintenance Of Translational Fidelity
Pathways		tRNA modification in the nucleus and cytosol
Drugs
Diseases
GWAS		Acute insulin response ( 28490609) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alzheimer disease and age of onset ( 26830138) Bipolar disorder ( 25827505) Birth weight ( 23202124 31043758 27680694) Bladder cancer ( 24163127) Blond vs. brown/black hair color ( 30531825) Blood glucose levels ( 31928498) Blood sugar levels ( 29403010) Body mass index ( 22344219 29381148 24861553 28892062) Body mass index (SNP x SNP interaction) ( 22344221) Breast cancer ( 29059683) Chloride levels ( 29403010) Cholesterol efflux capacity ( 29674289) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive function ( 25644384) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Crohn's disease ( 18587394 28067908 21102463) Cutaneous malignant melanoma ( 32341527 26237428) Depression in smokers ( 30219690) Diabetes (gestational) ( 22233651) Endometrial cancer ( 27008869) Estimated glomerular filtration rate ( 31451708) Fasting blood glucose ( 25631608) Fasting glucose ( 33402679 34059833) Fasting glucose change (short-term) ( 31263163) Fasting plasma glucose ( 25187374) Femoral neck bone mineral density ( 29499414 22504420) General cognitive ability ( 29844566) Glucose homeostasis traits ( 25524916) Glycated hemoglobin levels ( 22290723 24647736 34059833 28898252) Glycemic traits ( 23575436) Hematological and biochemical traits ( 31902109) Hemoglobin A1c levels ( 29403010) Ileal carcinoids ( 21139019) Incremental insulin ( 24699409) Inflammatory bowel disease ( 28067908) Insulin disposition index ( 24699409) Insulin levels ( 24699409) Insulin levels adjusted for BMI ( 24699409) Insulin secretion rate ( 28490609) Insulin-related traits (multivariate analysis) ( 32002517) Lumbar spine bone mineral density ( 29499414) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Melanoma ( 28212542) Metabolically unhealthy in normal weight ( 33500527) Metabolite levels ( 23823483) Monocyte count ( 32888494) Neutrophil count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Obesity-related traits ( 23251661) Pancreatic beta-cell glucose sensitivity ( 32944759) Peak insulin response ( 28490609) Prevalent type 2 diabetes ( 28406950) Prostate cancer ( 25939597) Psoriasis vulgaris ( 26626624) Pulse pressure ( 30578418) Refractive error ( 32231278) Systolic blood pressure ( 30224653 31928498 30578418) Thoracic aortic calcification levels ( 31659325) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Type 2 diabetes ( 21490949 32794382 27189021 22885922 18372903 24509480 30054458 18711366 22693455 26961502 29358691 30297969 19734900 25483131 17554300 26818947 23945395 31118516 22961080 32499647 20581827 19401414 17463246 30718926 17463248 17463249 28869590 17460697) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		3 interacting genes: LCK OGT TRIM54
Entrez ID		54901
HPRD ID		13022
Ensembl ID		ENSG00000145996
Uniprot IDs		Q5VV42
PDB IDs
Enriched GO Terms of Interacting Partners?
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