PDE8A

Description		phosphodiesterase 8A
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GO Annotations	Cellular Component	Cytosol Extracellular Exosome
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Kinase Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Positive Regulation Of Protein Phosphorylation CAMP Catabolic Process Regulation Of Transcription, DNA-templated Signal Transduction Negative Regulation Of Cell Death Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		G alpha (s) signalling events
Drugs		Caffeine 3-isobutyl-1-methyl-7H-xanthine Trapidil
Diseases
GWAS		Bulimia nervosa ( 23568457) Central corneal thickness ( 20719862) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Medication use (diuretics) ( 31015401) Neurofibrillary tangles ( 31497858) Systolic blood pressure ( 30224653 30578418) Testicular germ cell tumor ( 28604728) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		1 interacting genes: SEC11A
Entrez ID		5151
HPRD ID		09114
Ensembl ID		ENSG00000073417
Uniprot IDs		A0A024RC53 O60658
PDB IDs		1LHQ 1LXX 3ECM 3ECN
Enriched GO Terms of Interacting Partners?
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