NOX4

Description		NADPH oxidase 4
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Nucleolus Mitochondrion Endoplasmic Reticulum Membrane Plasma Membrane Focal Adhesion Integral Component Of Membrane Apical Plasma Membrane NADPH Oxidase Complex Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum
	Molecular Function	Nucleotide Binding Protein Binding Electron Transfer Activity NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Oxygen Sensor Activity Heme Binding Flavin Adenine Dinucleotide Binding Modified Amino Acid Binding Protein Tyrosine Kinase Binding
	Biological Process	Cell Morphogenesis Response To Hypoxia Heart Process Superoxide Metabolic Process Defense Response Inflammatory Response Cell Aging Negative Regulation Of Cell Population Proliferation Gene Expression Positive Regulation Of Smooth Muscle Cell Migration Electron Transport Chain Superoxide Anion Generation Positive Regulation Of Apoptotic Process Homocysteine Metabolic Process Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To CAMP Cellular Response To Gamma Radiation Cellular Response To Transforming Growth Factor Beta Stimulus Reactive Oxygen Species Metabolic Process Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Detoxification of Reactive Oxygen Species STAT5 activation downstream of FLT3 ITD mutants Signaling by FLT3 fusion proteins
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 30578418) Fish- and plant-related diet ( 32066663) Gut microbiota relative abundance (Streptococcus) ( 33208821) Health literacy ( 31250787) Height ( 31562340) Homocysteine levels ( 23824729) Obesity-related traits ( 23251661) Pulse pressure ( 28135244 27841878 29403010 28739976 30487518 30578418) Severe diabetic retinopathy in type 2 diabetes ( 30178632) Systolic blood pressure ( 27841878 30487518 30578418) Triglyceride levels ( 31647587 34074324)
Interacting Genes		2 interacting genes: PTPN11 TLR4
Entrez ID		50507
HPRD ID		09243
Ensembl ID		ENSG00000086991
Uniprot IDs		B3KQ17 B7Z523 B7Z529 Q9NPH5
PDB IDs
Enriched GO Terms of Interacting Partners?
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