P2RX3

Description		purinergic receptor P2X 3
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GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Neuronal Cell Body Terminal Bouton Dendritic Spine Receptor Complex Membrane Raft Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Integral Component Of Presynaptic Membrane
	Molecular Function	Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity ATP Binding Identical Protein Binding
	Biological Process	Response To Hypoxia Signal Transduction Neuromuscular Synaptic Transmission Response To Heat Response To Cold Response To Mechanical Stimulus Response To Carbohydrate Positive Regulation Of Calcium Ion Transport Into Cytosol Urinary Bladder Smooth Muscle Contraction Neuronal Action Potential Peristalsis Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Synaptic Plasticity Positive Regulation Of Calcium-mediated Signaling Sensory Perception Of Taste Excitatory Postsynaptic Potential Behavioral Response To Formalin Induced Pain Protein Homotrimerization Cellular Response To ATP Inorganic Cation Transmembrane Transport Positive Regulation Of Sensory Perception Of Pain
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis
Drugs		Promethazine
Diseases
GWAS		Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Eosinophil percentage of white cells ( 27863252) Hypertrophic cardiomyopathy (sarcomere positive) ( 33495597) Low high density lipoprotein cholesterol levels ( 26879886) Triglyceride levels ( 32203549)
Interacting Genes		1 interacting genes: P2RX2
Entrez ID		5024
HPRD ID		09016
Ensembl ID		ENSG00000109991
Uniprot IDs		P56373
PDB IDs		5SVJ 5SVK 5SVL 5SVM 5SVP 5SVQ 5SVR 5SVS 5SVT 5YVE 6AH4 6AH5
Enriched GO Terms of Interacting Partners?
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