ZFHX3

Description		zinc finger homeobox 3
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Enzyme Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Brain Development Muscle Organ Development Circadian Regulation Of Gene Expression Regulation Of Neuron Differentiation Positive Regulation Of Cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Cycle Response To Transforming Growth Factor Beta Regulation Of Locomotor Rhythm
Pathways		RUNX3 regulates CDKN1A transcription
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818 28416822 30061737 29892015 19597491 19597492 22544366) Behavioural changes in frontotemporal lobe dementia ( 29724592) Body mass index ( 28892062 29273807) Brain morphology (MOSTest) ( 32665545) Cardioembolic stroke (CCS and TOAST classification) ( 32047268) Cardioembolic stroke (CCS or TOAST classification) ( 32047268) Cardioembolic stroke (CCSc classification) ( 32047268) Cardioembolic stroke (CCSp classification) ( 32047268) Cardioembolic stroke (TOAST classification) ( 32047268) Cardiovascular death or myocardial infarction in response to clopidogrel treatment ( 32472697) Chronotype ( 30696823) Early onset atrial fibrillation ( 28460022) Estimated glomerular filtration rate ( 31152163 31015462 31451708) General risk tolerance (MTAG) ( 30643258) Glucocorticoid-induced osteonecrosis ( 26265699) Heel bone mineral density ( 30598549) Hypospadias ( 25108383) Incident atrial fibrillation ( 28416818) Ischemic stroke ( 29531354) Ischemic stroke (cardioembolic) ( 26708676 29531354) Kawasaki disease ( 19132087) LDL cholesterol ( 21347282) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483 22916037) Morning person ( 30696823) Nose morphology ( 29921221) Number of sexual partners ( 30643258) Photic sneeze reflex ( 27182965) Prevalent atrial fibrillation ( 28416818) Refractive error ( 32231278) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Risk-taking tendency (4-domain principal component model) ( 30643258) Serum alkaline phosphatase levels ( 33547301) Sick sinus syndrome ( 33580673) Smoking status (ever vs never smokers) ( 30643258) Stroke ( 29531354) Stroke (ischemic) ( 23041239) Type 2 diabetes ( 32499647)
Interacting Genes		37 interacting genes: ALKBH4 AURKA BHLHE40 C11orf49 CEP70 CNOT2 COPS6 DEUP1 DYNC1LI2 EFHC2 GOLGA2 GOLGA6L9 HIVEP1 KRT31 KRT34 KRT40 LMNB2 MSX2 MTUS2 MYB NINL PIAS3 PIBF1 PICK1 POU2F1 POU6F2 PRPF40A RBM11 SPECC1L TACC1 TLE5 TRIM27 TRIM54 TRIML2 TTC23 USHBP1 ZNF620
Entrez ID		463
HPRD ID		00075
Ensembl ID		ENSG00000140836
Uniprot IDs		Q15911 Q8N2Y6
PDB IDs		2DA1 2DA2 2DA3
Enriched GO Terms of Interacting Partners?
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