FADS1

Description		fatty acid desaturase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	C-5 Sterol Desaturase Activity Linoleoyl-CoA Desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Omega-6 Fatty Acid Desaturase Activity Acyl-CoA Delta5-desaturase Activity
	Biological Process	Regulation Of Transcription, DNA-templated Lipid Metabolic Process Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process
Pathways		PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs		alpha-Linolenic acid Icosapent
Diseases
GWAS		Alanine transaminase levels ( 29403010) Aortic valve stenosis ( 32186652) Asthma ( 31959851 34103634 32296059 31619474) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 24097068 25961943 20686565) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 28067908 21102463) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Eosinophil counts ( 27863252) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting glucose ( 33402679) Fatty acid desaturase activity (adipose tissue) ( 30453627) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) Glycerophospholipid levels ( 26068415) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 24097068 20864672 19060906 25961943 20686565) HDL cholesterol levels ( 28334899) Heart rate ( 23583979) Height ( 25429064) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29615537) Homeostasis model assessment of beta-cell function ( 20081858) Inflammatory bowel disease ( 23128233) Iron status biomarkers (total iron binding capacity) ( 33536631) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 24097068 19060910 30275531 25961943 20686565) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 33972514 22001757) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 32888494 27863252) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 23281178 23823483 23378610 22916037 20037589 19043545) Metabolite levels (lipid measures) ( 27005778) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 32888494 27863252) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Oleic acid (18:1n-9) levels ( 28298293 23362303) Palmitoleic acid (16:1n-7) levels ( 28298293 23362303) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 32888494 27863252) Platelet distribution width ( 32888494) PR interval ( 32439900) QT interval ( 30679814) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Rheumatoid arthritis ( 30423114 24390342) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Serum metabolite concentrations in chronic kidney disease ( 33838163 29545352) Serum metabolite levels ( 31636271 33031748 23093944) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Sphingolipid levels ( 26068415 22359512) Stearic acid (18:0) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29615537) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 29403010 33339817) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 20864672 19060906 25961943 20686565) Vaccenic acid (18:1n-7) levels ( 28298293) Vitamin C levels ( 33203707) White blood cell count ( 32888494 27863252) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		3 interacting genes: EEF1G POLR2E XRN1
Entrez ID		3992
HPRD ID		06935
Ensembl ID		ENSG00000149485
Uniprot IDs		A0A0A0MR51 O60427
PDB IDs
Enriched GO Terms of Interacting Partners?
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