GRM8

Description		glutamate metabotropic receptor 8
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity Group III Metabotropic Glutamate Receptor Activity G Protein-coupled Receptor Activity Glutamate Receptor Activity
	Biological Process	Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Visual Perception Regulation Of Synaptic Transmission, Glutamatergic
Pathways		G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors)
Drugs		Glutamic acid
Diseases
GWAS		Anti-saccade response ( 29064472 25387707) Anxiety ( 33859377) Carotid atherosclerosis in HIV infection ( 20009918) Chemerin levels ( 20237162) Creutzfeldt-Jakob disease (sporadic) ( 25918841) Depression (quantitative trait) ( 20800221) Experiencing mood swings ( 29500382) Fasting glucose change (long-term) ( 31263163) Feeling hurt ( 29500382) Feeling worry ( 29500382) Gastroesophageal reflux disease ( 34187846 31527586) General factor of neuroticism ( 30867560) Hearing function ( 25060954) Hip circumference adjusted for BMI ( 28552196) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Neurociticism ( 29500382) Response to selective serotonin reuptake inhibitors and depression ( 27622933) Smoking initiation ( 30617275) Type 2 diabetes ( 32499647) Worry too long after an embarrassing experience ( 29500382) Worry/vulnerability (special factor of neuroticism) ( 30867560)
Interacting Genes		5 interacting genes: DNAJC5 FLNA GPRASP1 PIAS1 PIAS2
Entrez ID		2918
HPRD ID		03071
Ensembl ID		ENSG00000179603
Uniprot IDs		O00222
PDB IDs		6BSZ 6BT5 6E5V
Enriched GO Terms of Interacting Partners?
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