GRM5

Description		glutamate metabotropic receptor 5
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Schaffer Collateral - CA1 Synapse Postsynaptic Density Membrane
	Molecular Function	Adenylate Cyclase Inhibiting G Protein-coupled Glutamate Receptor Activity G Protein-coupled Receptor Activity Protein Binding Glutamate Receptor Activity Protein Tyrosine Kinase Activator Activity Identical Protein Binding G Protein-coupled Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Protein Tyrosine Kinase Binding
	Biological Process	Regulation Of Protein Phosphorylation Regulation Of Translation Regulation Of Translational Elongation Adenylate Cyclase-inhibiting G Protein-coupled Glutamate Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Glutamate Receptor Signaling Pathway G Protein-coupled Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Learning Or Memory Learning Locomotory Behavior Calcium-mediated Signaling Using Intracellular Calcium Source Regulation Of Long-term Neuronal Synaptic Plasticity Synapse Organization Cognition Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Protein Tyrosine Kinase Activity Modulation Of Age-related Behavioral Decline Postsynaptic Modulation Of Chemical Synaptic Transmission Trans-synaptic Signaling By Endocannabinoid, Modulating Synaptic Transmission Regulation Of Postsynaptic Cytosolic Calcium Ion Concentration Regulation Of Intracellular Calcium Activated Chloride Channel Activity Cellular Response To Amyloid-beta
Pathways		G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins Neurexins and neuroligins
Drugs		Acamprosate ADX10059 Rufinamide Dipraglurant
Diseases
GWAS		Attention deficit hyperactivity disorder ( 22012869) Blond vs. brown/black hair color ( 30531825) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Depression ( 33859377) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Hair color ( 30664655) Hypertension ( 31879980) Neurociticism ( 29500382) Nonsyndromic cleft lip ( 31609978) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Retinal detachment ( 31816047) Retinal detachment or retinal break ( 31816047) Rheumatoid arthritis (ACPA-negative) ( 24532677) Skin pigmentation ( 31315583 30664655) Skin pigmentation (conditioned on rs1426654 and rs35397) ( 31315583) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Tanning ( 19340012)
Interacting Genes		19 interacting genes: ACTN1 CALM1 CALM2 CALM3 EFNB2 FLNA GPRASP1 HOMER1 HOMER3 PRKCA PRKCB PRKCD PRKCE PRKCG PRKCQ PRKCZ RGS12 SIAH1 TAMALIN
Entrez ID		2915
HPRD ID		04980
Ensembl ID		ENSG00000168959
Uniprot IDs		A8K5P7 P41594
PDB IDs		3LMK 4OO9 5CGC 5CGD 6N4X 6N4Y 6N50 6N51 6N52
Enriched GO Terms of Interacting Partners?
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