GREM1

Description		gremlin 1, DAN family BMP antagonist
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GO Annotations	Cellular Component	Extracellular Space Cell Surface Collagen-containing Extracellular Matrix
	Molecular Function	Cytokine Activity Protein Binding Morphogen Activity Transmembrane Receptor Protein Tyrosine Kinase Activator Activity BMP Binding Protein Homodimerization Activity Vascular Endothelial Growth Factor Receptor 2 Binding Receptor Ligand Activity
	Biological Process	Cell Morphogenesis Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Receptor Internalization Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Myocardial Precursor Cell Differentiation Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Apoptotic Process Signal Transduction Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Proximal/distal Pattern Formation Regulation Of Epithelial To Mesenchymal Transition Collagen Fibril Organization Negative Regulation Of Cell Growth Embryonic Limb Morphogenesis Negative Regulation Of Bone Mineralization Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Chondrocyte Differentiation Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Osteoblast Proliferation Sequestering Of BMP From Receptor Via BMP Binding Negative Regulation Of Apoptotic Process Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Bone Remodeling Determination Of Dorsal Identity Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Focal Adhesion Assembly Positive Regulation Of Telomerase Activity Limb Development Negative Regulation Of Pathway-restricted SMAD Protein Phosphorylation Ureteric Bud Formation Positive Regulation Of Protein Tyrosine Kinase Activity Signal Transduction By P53 Class Mediator Negative Regulation Of Monocyte Chemotaxis Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Negative Regulation Of Osteoclast Proliferation Positive Regulation Of Peptidyl-tyrosine Autophosphorylation Negative Regulation Of Bone Trabecula Formation Negative Regulation Of Bone Mineralization Involved In Bone Maturation Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Signaling Receptor Activity Positive Regulation Of Cardiac Muscle Cell Differentiation
Pathways
Drugs
Diseases
GWAS		Chin dimples ( 27182965) Colorectal cancer ( 25990418 21761138 26151821 24737748 23266556) Colorectal cancer or advanced adenoma ( 30510241) Haemorrhoidal disease ( 33888516) Hypospadias ( 25108383) Metabolite levels ( 23823483) Monobrow ( 27182965) Orofacial clefts ( 20023658)
Interacting Genes		4 interacting genes: BMP2 KRTAP12-2 MDFI YWHAH
Entrez ID		26585
HPRD ID		07048
Ensembl ID		ENSG00000166923
Uniprot IDs		A6XAA7 B3KTR9 O60565
PDB IDs		5AEJ
Enriched GO Terms of Interacting Partners?
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