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NNT

Description nicotinamide nucleotide transhydrogenase
Image
GO Annotations Cellular Component
  • Mitochondrion
  • Mitochondrial Inner Membrane
  • Mitochondrial Respirasome
  • Membrane
  • Integral Component Of Membrane
Molecular Function
  • NAD(P)+ Transhydrogenase (B-specific) Activity
  • NAD(P)+ Transhydrogenase Activity
  • NADP Binding
  • NAD Binding
Biological Process
  • Negative Regulation Of Protein Phosphorylation
  • Tricarboxylic Acid Cycle
  • NADPH Regeneration
  • Positive Regulation Of Mitochondrial Membrane Potential
  • Oxygen Homeostasis
  • Response To Vitamin
  • Negative Regulation Of Apoptotic Process
  • Cell Redox Homeostasis
  • Reactive Oxygen Species Metabolic Process
  • Cellular Oxidant Detoxification
  • Proton Transmembrane Transport
  • Positive Regulation Of Hydrogen Peroxide Catabolic Process
Pathways
  • Citric acid cycle (TCA cycle)
Drugs
  • NADH
  • 7-thionicotinamide-adenine-dinucleotide phosphate
  • Nicotinamide adenine dinucleotide phosphate
  • Xanthinol
Diseases
GWAS
  • Apolipoprotein A1 levels ( 32203549)
  • FEV1 ( 30804560)
  • Lung function (FVC) ( 30804560)
  • Peak expiratory flow ( 30804560)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Pulse pressure ( 30224653)
  • Subcutaneous adipose tissue ( 29178545)
Interacting Genes 1 interacting genes: MVP
Entrez ID 23530
HPRD ID 09715
Ensembl ID ENSG00000112992
Uniprot IDs A0A024R0C3 E9PCX7 Q13423
PDB IDs 1DJL 1PT9 1U31
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025