KDM6B

Description		lysine demethylase 6B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm MLL3/4 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Beta-catenin Binding Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3-tri/di-methyl-lysine-27 Demethylase Activity
	Biological Process	Inflammatory Response To Antigenic Stimulus Chromatin Remodeling Heart Development Regulation Of Gene Expression Response To Activity Hippocampus Development Cell Fate Commitment Endothelial Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Cardiac Muscle Cell Differentiation Response To Fungicide Cellular Response To Hydrogen Peroxide Histone H3-K27 Demethylation Positive Regulation Of Cold-induced Thermogenesis
Pathways		Oxidative Stress Induced Senescence HDMs demethylate histones
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Brain morphology (MOSTest) ( 32665545) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 25429064 29782485) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Monocyte percentage of white cells ( 32888494 27863252) Neutrophil count ( 32888494) Plateletcrit ( 32888494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)
Interacting Genes		4 interacting genes: CREBBP CSNK2B H3C1 TK1
Entrez ID		23135
HPRD ID		18983
Ensembl ID		ENSG00000132510
Uniprot IDs		O15054
PDB IDs		2XUE 2XXZ 4ASK 5FP3 5OY3 6F6D
Enriched GO Terms of Interacting Partners?
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