FLG

Description		filaggrin
Image
GO Annotations	Cellular Component	Cornified Envelope Nucleus Cytosol Intermediate Filament Keratohyalin Granule Cytoplasmic Ribonucleoprotein Granule Collagen-containing Extracellular Matrix
	Molecular Function	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Skin Epidermis Transition Metal Ion Binding
	Biological Process	Multicellular Organism Development Peptide Cross-linking Keratinocyte Differentiation Establishment Of Skin Barrier
Pathways		Formation of the cornified envelope
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23886662 21666691 25574825 26482879) Atopic march ( 26542096) Eating disorders ( 23568457) Eczema ( 31361310) Male-pattern baldness ( 28196072)
Interacting Genes		3 interacting genes: CSNK2A1 PCSK6 UCHL5
Entrez ID		2312
HPRD ID		15920
Ensembl ID		ENSG00000143631
Uniprot IDs		P20930
PDB IDs		4PCW
Enriched GO Terms of Interacting Partners?
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