FGF1

Description		fibroblast growth factor 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cell Cortex Extracellular Matrix
	Molecular Function	Fibroblast Growth Factor Receptor Binding Integrin Binding Protein Binding Growth Factor Activity Heparin Binding Hsp70 Protein Binding S100 Protein Binding
	Biological Process	Angiogenesis Organ Induction Positive Regulation Of Protein Phosphorylation Signal Transduction Multicellular Organism Development Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Anatomical Structure Morphogenesis Animal Organ Morphogenesis Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Cell Differentiation Lung Development Regulation Of Cell Migration Positive Regulation Of Cell Migration Activation Of Protein Kinase B Activity Cellular Response To Heat Wound Healing Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cell Division Branch Elongation Involved In Ureteric Bud Branching Positive Regulation Of ERK1 And ERK2 Cascade Mesonephric Epithelium Development Regulation Of Endothelial Tube Morphogenesis Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Hepatocyte Proliferation Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR1b ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR2b ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR2 IIIa TM Signaling by FGFR3 point mutants in cancer
Drugs		Pentosan polysulfate Amlexanox Heparin Sucrosofate Formic acid O2-Sulfo-Glucuronic Acid N,O6-Disulfo-Glucosamine Naphthalene Trisulfonate Pazopanib 5-aminonaphthalene-2-sulfonic acid Foreskin fibroblast (neonatal) Foreskin keratinocyte (neonatal)
Diseases
GWAS		Body shape index ( 34021172) Cardiac hypertrophy ( 21348951) Central corneal thickness ( 32528159 29760442) Coronary artery disease ( 33020668) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Hip index ( 34021172) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Pre-treatment viral load in HIV-1 infection ( 31219150) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 31217584) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		16 interacting genes: CSNK2A1 CSNK2A2 CSNK2B FGFBP1 FGFR1 FGFR2 FGFR3 FGFR4 FIBP HSPA9 NRP1 PTX3 RPS2 S100A13 SYT1 VBP1
Entrez ID		2246
HPRD ID		00567
Ensembl ID		ENSG00000113578
Uniprot IDs		A8K147 P05230 Q16089
PDB IDs		1AXM 1DJS 1DZC 1DZD 1E0O 1EVT 1HKN 1JQZ 1JT3 1JT4 1JT5 1JT7 1JTC 1JY0 1K5U 1K5V 1M16 1NZK 1P63 1PZZ 1Q03 1Q04 1QCT 1RG8 1RML 1RY7 1YTO 1Z2V 1Z4S 2AFG 2AQZ 2AXM 2ERM 2HW9 2HWA 2HWM 2HZ9 2K43 2K4A 2K8R 2KI4 2KI6 2NTD 2Q9X 2RQ9 3B9U 3BA4 3BA5 3BA7 3BAD 3BAG 3BAH 3BAO 3BAQ 3BAU 3BAV 3BB2 3CQA 3CRG 3CRH 3CRI 3CU1 3FGM 3FJ8 3FJ9 3FJA 3FJB 3FJC 3FJD 3FJE 3FJF 3FJH 3FJI 3FJJ 3FJK 3HOM 3JUT 3K1X 3O3Q 3OJ2 3OJM 3OJV 3UD7 3UD8 3UD9 3UDA 4J23 4Q91 4Q9G 4Q9P 4QAL 4QBC 4QBV 4QC4 4QO3 4XKI 4YOL
Enriched GO Terms of Interacting Partners?
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