PHACTR1

Description		phosphatase and actin regulator 1
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GO Annotations	Cellular Component	Nucleus Cytosol Synapse
	Molecular Function	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Cerebral Cortex Development Actin Cytoskeleton Organization Actomyosin Structure Organization Actin Cytoskeleton Reorganization Negative Regulation Of Catalytic Activity Stress Fiber Assembly Cell Motility Dendrite Arborization Regulation Of Neuron Migration
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Alcohol consumption (drinks per week) ( 30643258 30679032) Basophil percentage of white cells ( 32888494) Blood pressure ( 22763476) Cervical artery dissection ( 25420145) Chronotype ( 30696823 26835600) Coronary artery calcification ( 22144573 23394302) Coronary artery disease ( 32469254 29212778 24262325 30104761 26343387 28714974 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 22745674 21846871 22751097 21378988 21378990) Decline in glucose metabolism in posterior cingulate cortex ( 29130521) Diastolic blood pressure ( 27618447) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Gait speed in old age ( 28077804) Hand grip strength ( 29691431) Headache ( 29397368) Hip geometry ( 17903296) HIV-1 viral setpoint ( 26039976) Hypertension ( 27618447) Idiopathic dilated cardiomyopathy ( 29495422) Medication use (antimigraine preparations) ( 31015401) Metabolite levels ( 23823483) Migraine ( 22683712 27182965 23793025 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Morning person ( 30696823) Myocardial infarction ( 33532862 26343387) Myocardial infarction (early onset) ( 19198609) Pulse pressure ( 28135244 27841878 27618447 30578418) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Spontaneous coronary artery dissection ( 32887874 32374345) Systolic blood pressure ( 27841878 27618447 30578418)
Interacting Genes		5 interacting genes: ACTA1 C14orf119 CBX8 LINC00839 PPP1CA
Entrez ID		221692
HPRD ID		12283
Ensembl ID		ENSG00000112137
Uniprot IDs		A0A6Q8PFA8 A0A6Q8PG87 B4DHU0 Q9C0D0
PDB IDs		6ZEE 6ZEF 6ZEG 6ZEH 6ZEI 6ZEJ
Enriched GO Terms of Interacting Partners?
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