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CYP51A1

Description cytochrome P450 family 51 subfamily A member 1
Image
GO Annotations Cellular Component
  • Endoplasmic Reticulum
  • Endoplasmic Reticulum Membrane
  • Membrane
  • Integral Component Of Membrane
Molecular Function
  • Monooxygenase Activity
  • Iron Ion Binding
  • Sterol 14-demethylase Activity
  • Oxidoreductase Activity
  • Heme Binding
Biological Process
  • Steroid Biosynthetic Process
  • Cholesterol Biosynthetic Process
  • Sterol Metabolic Process
  • Negative Regulation Of Protein Catabolic Process
  • Negative Regulation Of Protein Secretion
  • Demethylation
  • Negative Regulation Of Amyloid-beta Clearance
Pathways
  • Cholesterol biosynthesis
  • Endogenous sterols
  • Activation of gene expression by SREBF (SREBP)
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
  • Tioconazole
  • Itraconazole
  • Levoketoconazole
  • (S)-econazole
Diseases
GWAS
  • Hippocampal volume in Alzheimer's disease dementia ( 29274321)
  • Lifespan ( 25918517)
  • Pulse pressure ( 30578418)
Interacting Genes 4 interacting genes: GRM3 SHANK3 STT3B ZNF420
Entrez ID 1595
HPRD ID 03381
Ensembl ID ENSG00000001630
Uniprot IDs A0A0C4DFL7 Q16850
PDB IDs 3JUS 3JUV 3LD6 4UHI 4UHL 6Q2T 6UEZ
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025