NOMO1 - New-wiki

Novel	Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
Novel	BAIAP3	BAI1 associated protein 3
Novel	CASP4	caspase 4	NOD1/2 Signaling Pathway	Incadronic acid
Novel	CFB	complement factor B	Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade	Zinc 4-guanidinobenzoic acid Diisopropylphosphono Group MLN2222 Zinc acetate	Alternative complement pathway component defects, including the following four diseases: Factor B deficiency; Factor D deficiency; Factor H deficiency; Properdin deficiency
Novel	KCNA1	potassium voltage-gated channel subfamily A member 1	Voltage gated Potassium channels	Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine	Episodic ataxias
Novel	MPV17L	MPV17 mitochondrial inner membrane protein like
Novel	NDE1	nudE neurodevelopment protein 1	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation
Novel	NTAN1	N-terminal asparagine amidase
Novel	PDZD3	PDZ domain containing 3	Intestinal infectious diseases
Novel	PPIE	peptidylprolyl isomerase E	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Neutrophil degranulation mRNA Splicing - Major Pathway
Novel	VWF	von Willebrand factor	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants Signaling by RAF1 mutants Defective F8 cleavage by thrombin Defective F8 binding to von Willebrand factor	Antihemophilic factor, human recombinant Egaptivon pegol Caplacizumab Simoctocog alfa Antihemophilic Factor (Recombinant), PEGylated Susoctocog alfa Efmoroctocog alfa Lonoctocog alfa Moroctocog alfa	Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
Novel	ZNF75A	zinc finger protein 75a	Generic Transcription Pathway
	ATF7IP	activating transcription factor 7 interacting protein	PKMTs methylate histone lysines
	BAG6	BAG cochaperone 6	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
	ECT2	epithelial cell transforming 2	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
	EXOSC10	exosome component 10	Major pathway of rRNA processing in the nucleolus and cytosol
	NCLN	nicalin
	SHBG	sex hormone binding globulin		Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
	STAT1	signal transducer and activator of transcription 1	Interleukin-6 signaling ISG15 antiviral mechanism Signaling by SCF-KIT Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction Interleukin-4 and Interleukin-13 signaling Interleukin-20 family signaling Regulation of RUNX2 expression and activity Interleukin-35 Signalling Interleukin-9 signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Interleukin-27 signaling Interleukin-21 signaling Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Growth hormone receptor signaling		Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF) IFN-gamma/IL-12 axis, including the following five diseases: IL-12 p40 subunit deficiency; IL-12 receptor (IL-12R) beta1 chain deficiency; IFN-gamma receptor (IFN gamma R) alpha chain deficiency; IFN-gamma receptor (IFN gamma R) beta chain deficiency; STAT-1 deficiency
	TOM1L1	target of myb1 like 1 membrane trafficking protein
	TRIM55	tripartite motif containing 55

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