Search Results for: LRP1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel CSRP2 cysteine and glycine rich protein 2
Novel NAB2 NGFI-A binding protein 2
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
Novel PIGA phosphatidylinositol glycan anchor biosynthesis class A
  • Synthesis of glycosylphosphatidylinositol (GPI)
  • Paroxysmal nocturnal hemoglobinuria (PNH)
Novel PMEL premelanosome protein
A2M alpha-2-macroglobulin
  • Platelet degranulation
  • Intrinsic Pathway of Fibrin Clot Formation
  • Degradation of the extracellular matrix
  • Rho GTPase cycle
  • HDL assembly
  • Becaplermin
  • Cisplatin
  • Bacitracin
  • Zinc
  • Ocriplasmin
  • Silver
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
ANAPC10 anaphase promoting complex subunit 10
  • Inactivation of APC/C via direct inhibition of the APC/C complex
  • APC/C:Cdc20 mediated degradation of Cyclin B
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
  • Regulation of APC/C activators between G1/S and early anaphase
  • APC/C:Cdc20 mediated degradation of mitotic proteins
  • Phosphorylation of the APC/C
  • APC-Cdc20 mediated degradation of Nek2A
  • Separation of Sister Chromatids
  • Senescence-Associated Secretory Phenotype (SASP)
  • CDK-mediated phosphorylation and removal of Cdc6
  • Transcriptional Regulation by VENTX
  • Aberrant regulation of mitotic exit in cancer due to RB1 defects
  • Antigen processing: Ubiquitination & Proteasome degradation
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B
APBA2 amyloid beta precursor protein binding family A member 2
  • Neurexins and neuroligins
APBB1 amyloid beta precursor protein binding family B member 1
  • Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
APOE apolipoprotein E
  • Nuclear signaling by ERBB4
  • Scavenging by Class A Receptors
  • Scavenging by Class A Receptors
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
  • Post-translational protein phosphorylation
  • Chylomicron assembly
  • Chylomicron remodeling
  • Chylomicron clearance
  • Chylomicron clearance
  • HDL remodeling
  • NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
  • Retinoid metabolism and transport
  • Retinoid metabolism and transport
  • Zinc
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Lipoprotein glomerulopathy
  • Hyperlipoproteinemia, type III; Dysbetalipoproteinemia
  • Alzheimer's disease (AD)
APP amyloid beta precursor protein
  • Platelet degranulation
  • ECM proteoglycans
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (q) signalling events
  • G alpha (i) signalling events
  • Lysosome Vesicle Biogenesis
  • Formyl peptide receptors bind formyl peptides and many other ligands
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • The NLRP3 inflammasome
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Post-translational protein phosphorylation
  • TRAF6 mediated NF-kB activation
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
  • Purinergic signaling in leishmaniasis infection
  • Amyloid fiber formation
  • Deferoxamine
  • Aluminium
  • Zinc
  • L-methionine (R)-S-oxide
  • Resveratrol
  • Tromethamine
  • Phenserine
  • Tetrathiomolybdate
  • CAD106
  • Mito-4509
  • Edonerpic
  • Dimercaprol
  • Copper
  • Florbetaben (18F)
  • Florbetapir (18F)
  • Flutemetamol (18F)
  • Zinc acetate
  • Aluminium phosphate
  • Aluminum acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Alzheimer's disease (AD)
BACE1 beta-secretase 1
  • Amyloid fiber formation
  • MMI-175
  • CTS-21166
  • N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
  • N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
  • N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
  • 4-(4-FLUOROBENZYL)PIPERIDINE
  • N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
  • 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
  • 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
  • N~3~-BENZYLPYRIDINE-2,3-DIAMINE
  • N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
  • N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
  • 4-(2-aminoethyl)-2-cyclohexylphenol
  • 4-(2-aminoethyl)-2-ethylphenol
  • 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
  • (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
  • 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
  • (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
  • N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
  • N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
  • (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
  • (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
  • N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
  • (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
  • N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
  • N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
  • 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
  • Verubecestat
BDNF brain derived neurotrophic factor
  • MECP2 regulates transcription of neuronal ligands
  • BDNF activates NTRK2 (TRKB) signaling
  • Activated NTRK2 signals through RAS
  • Activated NTRK2 signals through PLCG1
  • Activated NTRK2 signals through PLCG1
  • Activated NTRK2 signals through PI3K
  • Activated NTRK2 signals through FRS2 and FRS3
  • Activated NTRK2 signals through FRS2 and FRS3
  • Activated NTRK2 signals through FYN
  • NTRK2 activates RAC1
  • NTRK2 activates RAC1
  • Activated NTRK2 signals through CDK5
  • CX-717
  • Copper
  • Chondroitin sulfate
  • Esketamine
  • Congenital central hypoventilation syndrome (CCHS)
C3 complement C3
  • Alternative complement activation
  • Activation of C3 and C5
  • Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
  • Peptide ligand-binding receptors
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • G alpha (i) signalling events
  • Neutrophil degranulation
  • Post-translational protein phosphorylation
  • Purinergic signaling in leishmaniasis infection
  • Regulation of Complement cascade
  • Human immunoglobulin G
  • Zinc
  • S-Hydroxycysteine
  • Mirococept
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
  • Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
C4BPA complement component 4 binding protein alpha
  • Regulation of Complement cascade
  • Zinc
  • Copper
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
  • Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
CACNA1A calcium voltage-gated channel subunit alpha1 A
  • Presynaptic depolarization and calcium channel opening
  • Regulation of insulin secretion
  • Ergocalciferol
  • Enflurane
  • Phenytoin
  • Spironolactone
  • Magnesium sulfate
  • Verapamil
  • Levomenthol
  • Loperamide
  • Bepridil
  • Ziconotide
  • Dotarizine
  • Trimebutine
  • Benidipine
  • Cilnidipine
  • Lacidipine
  • Manidipine
  • Butamben
  • Bioallethrin
  • Bioallethrin
  • Bioallethrin
  • Episodic ataxias
  • Familial or sporadic hemiplegic migraine
  • Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
CALR calreticulin
  • ER-Phagosome pathway
  • Assembly of Viral Components at the Budding Site
  • Scavenging by Class A Receptors
  • Scavenging by Class A Receptors
  • Scavenging by Class F Receptors
  • Scavenging by Class F Receptors
  • ATF6 (ATF6-alpha) activates chaperone genes
  • Calnexin/calreticulin cycle
  • Antigen Presentation: Folding, assembly and peptide loading of class I MHC
  • Antihemophilic factor, human recombinant
  • Tenecteplase
  • Melatonin
  • Lanoteplase
  • Copper
  • Calcium citrate
  • Calcium Phosphate
  • Lonoctocog alfa
  • Moroctocog alfa
  • Calcium phosphate dihydrate
CANX calnexin
  • Assembly of Viral Components at the Budding Site
  • MHC class II antigen presentation
  • Interleukin-35 Signalling
  • Calnexin/calreticulin cycle
  • Interleukin-27 signaling
  • Maturation of spike protein
  • Maturation of spike protein
  • Antigen Presentation: Folding, assembly and peptide loading of class I MHC
  • Antigen Presentation: Folding, assembly and peptide loading of class I MHC
  • Antihemophilic factor, human recombinant
  • Tenecteplase
  • Lanoteplase
  • Calcium citrate
  • Calcium Phosphate
  • Lonoctocog alfa
  • Moroctocog alfa
  • Calcium phosphate dihydrate
CAV1 caveolin 1
  • Triglyceride catabolism
  • eNOS activation
  • NOSTRIN mediated eNOS trafficking
  • Basigin interactions
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • VEGFR2 mediated vascular permeability
  • Extra-nuclear estrogen signaling
  • FOXO-mediated transcription of cell cycle genes
  • Congenital generalized lipodystrophy (CGL)
CC2D1A coiled-coil and C2 domain containing 1A
  • Nonsyndromic autosomal recessive mental retardation (NS-ARMR)

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