Novel |
CSRP2 |
cysteine and glycine rich protein 2 |
|
|
|
Novel |
NAB2 |
NGFI-A binding protein 2 |
- NGF-stimulated transcription
- NGF-stimulated transcription
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
Novel |
PIGA |
phosphatidylinositol glycan anchor biosynthesis class A |
- Synthesis of glycosylphosphatidylinositol (GPI)
|
|
- Paroxysmal nocturnal hemoglobinuria (PNH)
|
Novel |
PMEL |
premelanosome protein |
|
|
|
|
A2M |
alpha-2-macroglobulin |
- Platelet degranulation
- Intrinsic Pathway of Fibrin Clot Formation
- Degradation of the extracellular matrix
- Rho GTPase cycle
- HDL assembly
|
- Becaplermin
- Cisplatin
- Bacitracin
- Zinc
- Ocriplasmin
- Silver
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
|
|
ANAPC10 |
anaphase promoting complex subunit 10 |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
ANKS1B |
ankyrin repeat and sterile alpha motif domain containing 1B |
|
|
|
|
APBA2 |
amyloid beta precursor protein binding family A member 2 |
- Neurexins and neuroligins
|
|
|
|
APBB1 |
amyloid beta precursor protein binding family B member 1 |
- Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
|
|
|
|
APOE |
apolipoprotein E |
- Nuclear signaling by ERBB4
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors
- Post-translational protein phosphorylation
- Chylomicron assembly
- Chylomicron remodeling
- Chylomicron clearance
- Chylomicron clearance
- HDL remodeling
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- Retinoid metabolism and transport
- Retinoid metabolism and transport
|
- Zinc
- Copper
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
- Lipoprotein glomerulopathy
- Hyperlipoproteinemia, type III; Dysbetalipoproteinemia
- Alzheimer's disease (AD)
|
|
APP |
amyloid beta precursor protein |
- Platelet degranulation
- ECM proteoglycans
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (q) signalling events
- G alpha (i) signalling events
- Lysosome Vesicle Biogenesis
- Formyl peptide receptors bind formyl peptides and many other ligands
- TAK1 activates NFkB by phosphorylation and activation of IKKs complex
- The NLRP3 inflammasome
- Advanced glycosylation endproduct receptor signaling
- Advanced glycosylation endproduct receptor signaling
- Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
- Post-translational protein phosphorylation
- TRAF6 mediated NF-kB activation
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
- Purinergic signaling in leishmaniasis infection
- Amyloid fiber formation
|
- Deferoxamine
- Aluminium
- Zinc
- L-methionine (R)-S-oxide
- Resveratrol
- Tromethamine
- Phenserine
- Tetrathiomolybdate
- CAD106
- Mito-4509
- Edonerpic
- Dimercaprol
- Copper
- Florbetaben (18F)
- Florbetapir (18F)
- Flutemetamol (18F)
- Zinc acetate
- Aluminium phosphate
- Aluminum acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
|
|
BACE1 |
beta-secretase 1 |
|
- MMI-175
- CTS-21166
- N-[amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
- N-[(5R,14R)-5-AMINO-5,14-DIMETHYL-4-OXO-3-OXA-18-AZATRICYCLO[15.3.1.1~7,11~]DOCOSA-1(21),7(22),8,10,17,19-HEXAEN-19-YL]-N-METHYLMETHANESULFONAMIDE
- N-[amino(imino)methyl]-2-[2-(2-chlorophenyl)-4-(4-propoxyphenyl)-3-thienyl]acetamide
- 4-(4-FLUOROBENZYL)PIPERIDINE
- N-{2-methyl-5-[(6-phenylpyrimidin-4-yl)amino]phenyl}methanesulfonamide
- 6-[2-(1H-INDOL-6-YL)ETHYL]PYRIDIN-2-AMINE
- 6-[2-(3'-METHOXYBIPHENYL-3-YL)ETHYL]PYRIDIN-2-AMINE
- N~3~-BENZYLPYRIDINE-2,3-DIAMINE
- N~3~-(3-PYRIDIN-3-YLBENZYL)PYRIDINE-2,3-DIAMINE
- N~3~-[3-(5-METHOXYPYRIDIN-3-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- 4-(2-aminoethyl)-2-cyclohexylphenol
- 4-(2-aminoethyl)-2-ethylphenol
- 4-[(1S)-1-(3-fluoro-4-methoxyphenyl)-2-(2-methoxy-5-nitrophenyl)ethyl]-1H-imidazol-2-amine
- (6R)-2-amino-6-[2-(3'-methoxybiphenyl-3-yl)ethyl]-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- 2-amino-6-[2-(1H-indol-6-yl)ethyl]pyrimidin-4(3H)-one
- (2S)-1-(2,5-dimethylphenoxy)-3-morpholin-4-ylpropan-2-ol
- N-(1-benzylpiperidin-4-yl)-4-sulfanylbutanamide
- N-[1-(2,6-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (2S)-4-(4-fluorobenzyl)-N-(2-sulfanylethyl)piperazine-2-carboxamide
- (2S)-4-(4-fluorobenzyl)-N-(3-sulfanylpropyl)piperazine-2-carboxamide
- N-[1-(5-bromo-2,3-dimethoxybenzyl)piperidin-4-yl]-4-sulfanylbutanamide
- (6S)-2-amino-6-(3'-methoxybiphenyl-3-yl)-3,6-dimethyl-5,6-dihydropyrimidin-4(3H)-one
- N~3~-[3-(1H-INDOL-6-YL)BENZYL]PYRIDINE-2,3-DIAMINE
- N~3~-[5-(1H-INDOL-6-YL)-2-(PYRIDIN-2-YLMETHOXY)BENZYL]PYRIDINE-2,3-DIAMINE
- 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
- Verubecestat
|
|
|
BDNF |
brain derived neurotrophic factor |
- MECP2 regulates transcription of neuronal ligands
- BDNF activates NTRK2 (TRKB) signaling
- Activated NTRK2 signals through RAS
- Activated NTRK2 signals through PLCG1
- Activated NTRK2 signals through PLCG1
- Activated NTRK2 signals through PI3K
- Activated NTRK2 signals through FRS2 and FRS3
- Activated NTRK2 signals through FRS2 and FRS3
- Activated NTRK2 signals through FYN
- NTRK2 activates RAC1
- NTRK2 activates RAC1
- Activated NTRK2 signals through CDK5
|
- CX-717
- Copper
- Chondroitin sulfate
- Esketamine
|
- Congenital central hypoventilation syndrome (CCHS)
|
|
C3 |
complement C3 |
- Alternative complement activation
- Activation of C3 and C5
- Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
- Peptide ligand-binding receptors
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- G alpha (i) signalling events
- Neutrophil degranulation
- Post-translational protein phosphorylation
- Purinergic signaling in leishmaniasis infection
- Regulation of Complement cascade
|
- Human immunoglobulin G
- Zinc
- S-Hydroxycysteine
- Mirococept
- Copper
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
- Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
- Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
|
|
C4BPA |
complement component 4 binding protein alpha |
- Regulation of Complement cascade
|
- Zinc
- Copper
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
|
- Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency
|
|
CACNA1A |
calcium voltage-gated channel subunit alpha1 A |
- Presynaptic depolarization and calcium channel opening
- Regulation of insulin secretion
|
- Ergocalciferol
- Enflurane
- Phenytoin
- Spironolactone
- Magnesium sulfate
- Verapamil
- Levomenthol
- Loperamide
- Bepridil
- Ziconotide
- Dotarizine
- Trimebutine
- Benidipine
- Cilnidipine
- Lacidipine
- Manidipine
- Butamben
- Bioallethrin
- Bioallethrin
- Bioallethrin
|
- Episodic ataxias
- Familial or sporadic hemiplegic migraine
- Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3)
|
|
CALR |
calreticulin |
- ER-Phagosome pathway
- Assembly of Viral Components at the Budding Site
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- Scavenging by Class F Receptors
- Scavenging by Class F Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Calnexin/calreticulin cycle
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
- Antihemophilic factor, human recombinant
- Tenecteplase
- Melatonin
- Lanoteplase
- Copper
- Calcium citrate
- Calcium Phosphate
- Lonoctocog alfa
- Moroctocog alfa
- Calcium phosphate dihydrate
|
|
|
CANX |
calnexin |
- Assembly of Viral Components at the Budding Site
- MHC class II antigen presentation
- Interleukin-35 Signalling
- Calnexin/calreticulin cycle
- Interleukin-27 signaling
- Maturation of spike protein
- Maturation of spike protein
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
- Antigen Presentation: Folding, assembly and peptide loading of class I MHC
|
- Antihemophilic factor, human recombinant
- Tenecteplase
- Lanoteplase
- Calcium citrate
- Calcium Phosphate
- Lonoctocog alfa
- Moroctocog alfa
- Calcium phosphate dihydrate
|
|
|
CAV1 |
caveolin 1 |
- Triglyceride catabolism
- eNOS activation
- NOSTRIN mediated eNOS trafficking
- Basigin interactions
- Disassembly of the destruction complex and recruitment of AXIN to the membrane
- VEGFR2 mediated vascular permeability
- Extra-nuclear estrogen signaling
- FOXO-mediated transcription of cell cycle genes
|
|
- Congenital generalized lipodystrophy (CGL)
|
|
CC2D1A |
coiled-coil and C2 domain containing 1A |
|
|
- Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
|