Search Results for: DYNC1I1

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
Novel DDX19B DEAD-box helicase 19B
Novel KLC2 kinesin light chain 2
  • MHC class II antigen presentation
  • RHO GTPases activate KTN1
  • COPI-dependent Golgi-to-ER retrograde traffic
  • Kinesins
Novel MCM7 minichromosome maintenance complex component 7
  • Activation of ATR in response to replication stress
  • Unwinding of DNA
  • Assembly of the pre-replicative complex
  • Orc1 removal from chromatin
  • Activation of the pre-replicative complex
  • Switching of origins to a post-replicative state
Novel NDUFV2 NADH:ubiquinone oxidoreductase core subunit V2
  • Respiratory electron transport
  • Complex I biogenesis
  • NADH
  • Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
Novel NPTX2 neuronal pentraxin 2
Novel NUP214 nucleoporin 214
  • ISG15 antiviral mechanism
  • Transport of the SLBP independent Mature mRNA
  • Transport of the SLBP Dependant Mature mRNA
  • Transport of Mature mRNA Derived from an Intronless Transcript
  • Transport of Mature mRNA derived from an Intron-Containing Transcript
  • Rev-mediated nuclear export of HIV RNA
  • Transport of Ribonucleoproteins into the Host Nucleus
  • NS1 Mediated Effects on Host Pathways
  • Viral Messenger RNA Synthesis
  • NEP/NS2 Interacts with the Cellular Export Machinery
  • Regulation of Glucokinase by Glucokinase Regulatory Protein
  • Nuclear import of Rev protein
  • Vpr-mediated nuclear import of PICs
  • snRNP Assembly
  • SUMOylation of DNA damage response and repair proteins
  • SUMOylation of ubiquitinylation proteins
  • Nuclear Pore Complex (NPC) Disassembly
  • Regulation of HSF1-mediated heat shock response
  • SUMOylation of SUMOylation proteins
  • HuR (ELAVL1) binds and stabilizes mRNA
  • SUMOylation of chromatin organization proteins
  • SUMOylation of RNA binding proteins
  • SUMOylation of DNA replication proteins
  • SUMOylation of DNA replication proteins
  • Transcriptional regulation by small RNAs
  • Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
  • tRNA processing in the nucleus
  • HCMV Early Events
  • HCMV Late Events
Novel SEM1 SEM1 26S proteasome subunit
  • Activation of NF-kappaB in B cells
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • ER-Phagosome pathway
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • Separation of Sister Chromatids
  • FCERI mediated NF-kB activation
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Regulation of ornithine decarboxylase (ODC)
  • ABC-family proteins mediated transport
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Hedgehog ligand biogenesis
  • Hh mutants are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • NIK-->noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • Ub-specific processing proteases
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • G2/M Checkpoints
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN stability and activity
  • Neddylation
  • Regulation of expression of SLITs and ROBOs
  • Interleukin-1 signaling
  • Negative regulation of NOTCH4 signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
Novel SERPINE1 serpin family E member 1
  • Platelet degranulation
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • ECM proteoglycans
  • Dissolution of Fibrin Clot
  • Alteplase
  • Urokinase
  • Reteplase
  • Anistreplase
  • Tenecteplase
  • Drotrecogin alfa
  • Troglitazone
  • Fibrinolysin
  • Copper
  • Inherited thrombophilia
Novel ZKSCAN1 zinc finger with KRAB and SCAN domains 1
  • Generic Transcription Pathway
ANXA7 annexin A7
BICD1 BICD cargo adaptor 1
  • COPI-independent Golgi-to-ER retrograde traffic
CADM4 cell adhesion molecule 4
CDKN1A cyclin dependent kinase inhibitor 1A
  • SCF(Skp2)-mediated degradation of p27/p21
  • AKT phosphorylates targets in the cytosol
  • Senescence-Associated Secretory Phenotype (SASP)
  • DNA Damage/Telomere Stress Induced Senescence
  • Constitutive Signaling by AKT1 E17K in Cancer
  • Interleukin-4 and Interleukin-13 signaling
  • TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
  • Cyclin E associated events during G1/S transition
  • Cyclin D associated events in G1
  • p53-Dependent G1 DNA Damage Response
  • Cyclin A:Cdk2-associated events at S phase entry
  • Transcriptional activation of cell cycle inhibitor p21
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • TFAP2 (AP-2) family regulates transcription of cell cycle factors
  • Transcriptional regulation by RUNX2
  • RUNX3 regulates CDKN1A transcription
  • Transcriptional regulation of granulopoiesis
  • FOXO-mediated transcription of cell cycle genes
  • Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
  • STAT5 activation downstream of FLT3 ITD mutants
  • Signaling by FLT3 fusion proteins
  • Arsenic trioxide
  • Cervical cancer
DNM2 dynamin 2
  • Toll Like Receptor 4 (TLR4) Cascade
  • Retrograde neurotrophin signalling
  • Gap junction degradation
  • Formation of annular gap junctions
  • NOSTRIN mediated eNOS trafficking
  • MHC class II antigen presentation
  • Lysosome Vesicle Biogenesis
  • Golgi Associated Vesicle Biogenesis
  • Recycling pathway of L1
  • Clathrin-mediated endocytosis
  • NGF-stimulated transcription
  • Centronuclear myopathy
  • Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
DYNLL1 dynein light chain LC8-type 1
  • Activation of BIM and translocation to mitochondria
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Macroautophagy
  • MHC class II antigen presentation
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • Regulation of PLK1 Activity at G2/M Transition
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • Loss of Nlp from mitotic centrosomes
  • Recruitment of mitotic centrosome proteins and complexes
  • Loss of proteins required for interphase microtubule organization from the centrosome
  • Recruitment of NuMA to mitotic centrosomes
  • Anchoring of the basal body to the plasma membrane
  • Intraflagellar transport
  • RHO GTPases Activate Formins
  • Neutrophil degranulation
  • COPI-mediated anterograde transport
  • COPI-independent Golgi-to-ER retrograde traffic
  • Mitotic Prometaphase
  • AURKA Activation by TPX2
  • HCMV Early Events
  • Aggrephagy
  • Aggrephagy
  • EML4 and NUDC in mitotic spindle formation
DYNLL2 dynein light chain LC8-type 2
  • Activation of BMF and translocation to mitochondria
  • Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
  • Macroautophagy
  • MHC class II antigen presentation
  • Separation of Sister Chromatids
  • Resolution of Sister Chromatid Cohesion
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • Intraflagellar transport
  • RHO GTPases Activate Formins
  • COPI-mediated anterograde transport
  • COPI-independent Golgi-to-ER retrograde traffic
  • Mitotic Prometaphase
  • HCMV Early Events
  • Aggrephagy
  • Aggrephagy
  • EML4 and NUDC in mitotic spindle formation
DYNLRB1 dynein light chain roadblock-type 1
  • Intraflagellar transport
DYNLT1 dynein light chain Tctex-type 1
  • Neutrophil degranulation
DYNLT3 dynein light chain Tctex-type 3
EMILIN1 elastin microfibril interfacer 1
  • Molecules associated with elastic fibres
  • Molecules associated with elastic fibres

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