CREB3L1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
ORMDL1	ORMDL sphingolipid biosynthesis regulator 1	Sphingolipid de novo biosynthesis
ORMDL2	ORMDL sphingolipid biosynthesis regulator 2	Sphingolipid de novo biosynthesis
PAQR6	progestin and adipoQ receptor family member 6
PEDS1-UBE2V1	PEDS1-UBE2V1 readthrough	NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Downstream TCR signaling FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Interleukin-1 signaling IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 Aggrephagy Aggrephagy TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation Antigen processing: Ubiquitination & Proteasome degradation
PEX16	peroxisomal biogenesis factor 16	Class I peroxisomal membrane protein import Class I peroxisomal membrane protein import		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
PGAP2	post-GPI attachment to proteins 2
PGRMC1	progesterone receptor membrane component 1	Neutrophil degranulation	Dextromethorphan Nortriptyline Sertraline
PLN	phospholamban	Ion homeostasis Ion transport by P-type ATPases
PLP1	proteolipid protein 1			Hereditary spastic paraplegia (SPG) Hypomyelinating leukodystrophy (HLD); Pelizaeus-Merzbacher disease (PMD)
PLP2	proteolipid protein 2
PLPP4	phospholipid phosphatase 4	Role of phospholipids in phagocytosis
PLPP6	phospholipid phosphatase 6	Cholesterol biosynthesis
PLPPR2	phospholipid phosphatase related 2	Lysosphingolipid and LPA receptors
PMP22	peripheral myelin protein 22	EGR2 and SOX10-mediated initiation of Schwann cell myelination		Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
PRKAB2	protein kinase AMP-activated non-catalytic subunit beta 2	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Carnitine metabolism Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs	Adenosine phosphate Acetylsalicylic acid Fostamatinib
PTPN9	protein tyrosine phosphatase non-receptor type 9	Interleukin-37 signaling
RFT1	RFT1 homolog	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective RFT1 causes RFT1-CDG (CDG-1n)		Congenital disorders of glycosylation (CDG) type I
RHBDD1	rhomboid domain containing 1
RHD	Rh blood group D antigen	Rhesus blood group biosynthesis
RNASE10	ribonuclease A family member 10 (inactive)

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