RHOA - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
MCF2L	MCF.2 cell line derived transforming sequence like	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
MPRIP	myosin phosphatase Rho interacting protein	Signaling by BRAF and RAF fusions
MYO9A	myosin IXA	Rho GTPase cycle
NET1	neuroepithelial cell transforming 1	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
NGEF	neuronal guanine nucleotide exchange factor	NRAGE signals death through JNK Rho GTPase cycle EPHA-mediated growth cone collapse EPHA-mediated growth cone collapse G alpha (12/13) signalling events
NOTCH1	notch receptor 1	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription		Bicuspid aortic valve Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
OPHN1	oligophrenin 1	Rho GTPase cycle		Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
OTUB1	OTU deubiquitinase, ubiquitin aldehyde binding 1	Ub-specific processing proteases Ovarian tumor domain proteases
PDE6D	phosphodiesterase 6D	ARL13B-mediated ciliary trafficking of INPP5E RAS processing
PITPNM1	phosphatidylinositol transfer protein membrane associated 1	Synthesis of PI
PKN1	protein kinase N1	RHO GTPases activate PKNs Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3	Fostamatinib
PKN2	protein kinase N2	RHO GTPases activate PKNs	Fostamatinib
PLCG1	phospholipase C gamma 1	ISG15 antiviral mechanism Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PLCG1 events in ERBB2 signaling DAG and IP3 signaling PLC-gamma1 signalling Synthesis of IP3 and IP4 in the cytosol Downstream signal transduction Generation of second messenger molecules Role of phospholipids in phagocytosis Role of phospholipids in phagocytosis PECAM1 interactions EGFR interacts with phospholipase C-gamma DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Role of second messengers in netrin-1 signaling VEGFR2 mediated cell proliferation VEGFR2 mediated cell proliferation Constitutive Signaling by EGFRvIII Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Signaling by FGFR3 point mutants in cancer RET signaling Activated NTRK2 signals through PLCG1 Activated NTRK2 signals through PLCG1 Erythropoietin activates Phospholipase C gamma (PLCG) Activated NTRK3 signals through PLCG1 Activated NTRK3 signals through PLCG1 FCGR3A-mediated IL10 synthesis Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
PLD1	phospholipase D1	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis Neutrophil degranulation	Choline LAX-101 Choline salicylate
PLEKHG2	pleckstrin homology and RhoGEF domain containing G2	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
PLEKHG4	pleckstrin homology and RhoGEF domain containing G4
PLEKHG6	pleckstrin homology and RhoGEF domain containing G6
PPP1R12A	protein phosphatase 1 regulatory subunit 12A	Regulation of PLK1 Activity at G2/M Transition RHO GTPases activate PKNs RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
PREX1	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
PREX2	phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2	Regulation of PTEN stability and activity

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