CTNNA3 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
NDUFB7	NADH:ubiquinone oxidoreductase subunit B7	Respiratory electron transport Complex I biogenesis	NADH
OIP5	Opa interacting protein 5	Deposition of new CENPA-containing nucleosomes at the centromere
ORC2	origin recognition complex subunit 2	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
PAX6	paired box 6	Regulation of gene expression in beta cells Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Activation of anterior HOX genes in hindbrain development during early embryogenesis		Aniridia Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP) Ocular coloboma, including: Coloboma of iris choroid and retina (COI); Coloboma of optic nerve (COLON)
PLAGL2	PLAG1 like zinc finger 2
PNMA1	PNMA family member 1
PNMA5	PNMA family member 5
POU6F2	POU class 6 homeobox 2
PPARA	peroxisome proliferator activated receptor alpha	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors	alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
PRR5	proline rich 5	PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation
REL	REL proto-oncogene, NF-kB subunit	Activation of NF-kappaB in B cells		Hodgkin lymphoma
RIPPLY1	ripply transcriptional repressor 1
RPS6KA5	ribosomal protein S6 kinase A5	ERK/MAPK targets CREB phosphorylation NCAM signaling for neurite out-growth Recycling pathway of L1 CD209 (DC-SIGN) signaling
SERTAD2	SERTA domain containing 2
SPATS1	spermatogenesis associated serine rich 1
STMN2	stathmin 2
TASOR2	transcription activation suppressor family member 2
TLX3	T cell leukemia homeobox 3			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
TNNI1	troponin I1, slow skeletal type	Striated Muscle Contraction
TNNI2	troponin I2, fast skeletal type	Striated Muscle Contraction		Distal arthrogryposis (DA)

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