ATXN1 - New-wiki

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CDRT15P3	CDRT15 pseudogene 3
CFL1	cofilin 1	Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Dodecyldimethylamine N-oxide Copper Artenimol
CHRNA7	cholinergic receptor nicotinic alpha 7 subunit	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	Choline Nicotine Butabarbital Butalbital Talbutal Pentobarbital Methadone Secobarbital Metharbital Dextromethorphan Thiopental Mecamylamine Galantamine Primidone Methylphenobarbital Ethanol Amantadine Phenobarbital Tubocurarine Varenicline Amobarbital Aprobarbital Butobarbital Heptabarbital Hexobarbital Barbital Dihydro-2-thioxo-5-((5-(2-(trifluoromethyl)phenyl)-2-furanyl)methyl)-4,6(1H,5H)-pyrimidinedione Acetylcholine Lobeline GTS-21 RPI-78M Epibatidine Cytisine Cannabidiol Encenicline Choline salicylate Medical Cannabis Nabiximols
CIC	capicua transcriptional repressor
CIRBP	cold inducible RNA binding protein
CLASRP	CLK4 associating serine/arginine rich protein
CLCN2	chloride voltage-gated channel 2	Stimuli-sensing channels	Lubiprostone Cobiprostone	Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
CLEC4F	C-type lectin domain family 4 member F
COIL	coilin
CPSF7	cleavage and polyadenylation specific factor 7	mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs
CREM	cAMP responsive element modulator
CRIP2	cysteine rich protein 2
CRK	CRK proto-oncogene, adaptor protein	ARMS-mediated activation ARMS-mediated activation Downstream signal transduction Regulation of actin dynamics for phagocytic cup formation p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAP1 and RAC1 MET receptor recycling Regulation of signaling by CBL FCGR3A-mediated phagocytosis
CRX	cone-rod homeobox			Leber congenital amaurosis (LCR) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
CRY2	cryptochrome circadian regulator 2	Circadian Clock
CST3	cystatin C	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA)
CUTC	cutC copper transporter	Ion transport by P-type ATPases
DAZ2	deleted in azoospermia 2
DAZAP2	DAZ associated protein 2
DCTN3	dynactin subunit 3	MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2

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